A5034732141- Neuroinflammation and Neurodegeneration Mechanisms
- Chemokine receptors and signaling
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Barrier Structure and Function Studies
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Polyomavirus and related diseases
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- HIV Research and Treatment
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
Third Dimension Technologies (United States)
2018-2025
Cleveland Clinic
2011-2023
Biogen (United States)
2013-2023
Cleveland Clinic Lerner College of Medicine
2011-2023
Yamaguchi University
2016-2021
Harvard University
2018-2021
Chugai Pharma (United States)
2021
Newbury College
2019-2020
Case Western Reserve University
1987-2019
University School
1987-2019
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and most common cause neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, patients have progressive deterioration that may reflect axonal loss. We conducted pathological studies brain tissues to define changes axons with multiple sclerosis.
Microglia, the macrophages of central nervous system parenchyma, have in normal healthy brain a distinct phenotype induced by molecules expressed on or secreted adjacent neurons and astrocytes, this is maintained part virtue blood-brain barrier's exclusion serum components. Microglia are continually active, their processes palpating surveying local microenvironment. The microglia rapidly change response to any disturbance homeostasis commonly referred as activated basis changes morphology...
Devic’s disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating of the CNS, characterized by attacks optic neuritis and myelitis. The mechanisms that result in selective localization lesions to nerves spinal cord are unknown. Serological clinical evidence B cell autoimmunity has been observed a high proportion patients with NMO. purpose this study was investigate importance humoral mechanisms, including complement activation, producing necrotizing demyelination seen...
Of mice and men's microglia Microglia are immune system cells that function in protecting maintaining the brain. Gosselin et al. examined epigenetics RNA transcripts from single microglial observed consistent profiles among samples despite differences age, sex, diagnosis. Mouse human demonstrated similar microglia-specific gene expression profiles, as well a shared environmental response collected either immediately after surgery (ex vivo) or culturing (in vitro). Interestingly, those genes...
Cortical disease has emerged as a critical aspect of the pathogenesis multiple sclerosis, being associated with progression and cognitive impairment. Most studies cortical lesions have focused on autopsy findings in patients long-standing, chronic, progressive noninflammatory nature these been emphasized. Magnetic resonance imaging indicate that damage occurs early disease.We evaluated prevalence character demyelinating sclerosis. tissues were obtained passing during biopsy sampling...
Chemokines direct tissue invasion by specific leukocyte populations. Thus, chemokines may play a role in multiple sclerosis (MS), an idiopathic disorder which the central nervous system (CNS) inflammatory reaction is largely restricted to mononuclear phagocytes and T cells. We asked whether were expressed CNS during acute demyelinating events analyzing cerebrospinal fluid (CSF), whose composition reflects extracellular space. During MS attacks, we found elevated CSF levels of three that act...
In the human disorder multiple sclerosis (MS) and in model experimental autoimmune encephalomyelitis (EAE), macrophages predominate demyelinated areas their numbers correlate to tissue damage. Macrophages may be derived from infiltrating monocytes or resident microglia, yet are indistinguishable by light microscopy surface phenotype. It is axiomatic that T cell–mediated macrophage activation critical for inflammatory demyelination EAE, precise details which injury takes place remain poorly...
Microglia, the tissue-resident macrophages in brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as Alzheimer's disease (AD). Here, using single-cell RNA sequencing, we determined transcriptome of more than 1,600 individual microglia cells isolated from hippocampus a mouse model severe neurodegeneration with AD-like phenotypes and control mice at multiple time points during progression neurodegeneration. In this model, discovered two...
Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B a cell type associated autoimmune diseases. generated Cxcr7 −/− mice but found that deficiency had little effect composition. However, most died at birth ventricular septal defects and semilunar heart valve malformation. Conditional deletion in...
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the cell types mechanisms underlying TREM2’s involvement neurodegeneration remain to be established. Here, we report that TREM2 is up-regulated surrounding amyloid deposits AD mouse models human tissue. was detected CD45hiLy6C+ cells, but not P2RY12+ parenchymal microglia. In mice deficient TREM2, macrophages are virtually...