A5100396611- Mechanisms of cancer metastasis
- Nitric Oxide and Endothelin Effects
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- Aortic Disease and Treatment Approaches
- Immune Response and Inflammation
- Aortic aneurysm repair treatments
- Adipokines, Inflammation, and Metabolic Diseases
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Plant Physiology and Cultivation Studies
- Lung Cancer Research Studies
- Proteins in Food Systems
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Eicosanoids and Hypertension Pharmacology
- Protein Kinase Regulation and GTPase Signaling
- Pulmonary Hypertension Research and Treatments
- Irrigation Practices and Water Management
- Food composition and properties
- Anesthesia and Pain Management
- Cancer therapeutics and mechanisms
University of California, Los Angeles
2014-2025
Beijing Technology and Business University
2023-2025
Chinese PLA General Hospital
2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Sun Yat-sen University
2019-2025
Nanjing University
2023-2025
Yangzhou University
2025
Institute of Earth Environment
2019-2024
Tianjin Medical University
2022-2024
Chinese Academy of Sciences
2008-2024
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage jaundice. In more cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur1. Here we report the complete genomic sequence representative virulent serovar type strain (Lai)2 Leptospira interrogans serogroup Icterohaemorrhagiae consisting 4.33-megabase large chromosome 359-kilobase small chromosome, total...
Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator chromatin remodeling, BRD4 promotes progression by regulating multiple genes. small-molecule inhibitor of BRD4, JQ1 has potent chemotherapeutic activity against various human cancers. However, whether potential anti-tumor effects and how regulates global transcription in gastric cancer (GC) largely unknown. In this research, we found was highly expressed GC tissues significantly...
Metastasis is a significant factor that affects the survival of patients with non-small cell lung cancer (NSCLC). Nevertheless, molecular regulatory mechanism underlying metastasis currently not fully understood. This study aims to identify important role miR-124-3p in NSCLC, thereby providing potential therapeutic intervention.Exosome secretion was determined by Nanoparticle Tracking Analysis (NTA) and uptake measured fluorescence inverted microscope. The binding between its upstream or...
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this regulated. Here we found nerve growth factor (NGF) produced by leptin receptor-expressing (LepR+) stromal cells required to maintain fibres in adult marrow. In nerveless marrow, steady-state haematopoiesis was normal and vascular were impaired myeloablation. LepR+ cells, the adipocytes they gave rise to, increased NGF...
Apolipoprotein A-I (ApoA-I) is the most abundant protein constituent of high-density lipoprotein (HDL). Reduced plasma HDL and ApoA-I levels have been found to be associated with obesity metabolic syndrome in human beings. However, whether or not has a direct effect on largely unknown. Here we analysed anti-obesity using two mouse models, transgenic overexpression mice administered an mimetic peptide D-4F. The were induced develop by feeding high fat diet. Both D-4F treatment could...
Long non‐coding RNAs (lncRNAs) have been verified to modulate the tumorigenesis of breast cancer at multiple levels. In present study, we aim investigate role lncRNA FEZF1‐AS1 on cancer‐stem like cells (BCSC) and potential regulatory mechanism. tissue, was up‐regulated compared with controls indicated poor prognosis patients. vitro experiments, significantly over‐expressed in cells, especially sphere subpopulation parental subpopulation. Loss‐of‐functional that, BCSC (MDA‐MB‐231 CSC, MCF‐7...
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal uncoupled eNOS this severe human disease. We also shown that activation NADPH oxidase (NOX) lies upstream eNOS. Therefore, identification specific NOX isoforms are required for uncoupling AAA would ultimately lead to novel therapies AAA. In present study, used Ang II infused hph-1 mice examine roles development generated double mutants hph-1-NOX1,...
The outbreak of COVID-19 has remained uncontained with urgent need for robust therapeutics. We have previously reported sex difference the first time indicating male predisposition. Males are more susceptible than females, and often to develop into severe cases higher mortality. This predisposition is potentially linked prevalence cigarette smoking. Nonetheless, we found that smoking extract (CSE) had no effect on angiotensin converting enzyme 2 (ACE2) transmembrane protease serine (TMPRSS2)...
Exploration of a novel and efficient sensing mechanism Au nanocluster (AuNC)-based electrochemiluminescence (ECL) sensors is still great challenge opportunity for further applications. Herein, we proposed that the electron transfer (ET) could be used as regulation factor construction an ECL-sensing platform based on AuNC probe. As proof-of-concept, ECL quenching effect Cu2+ pre-oxidation-treated l-methionine-capped AuNCs (OM-AuNCs) was investigated in detail. The results revealed after...
Background and Purpose Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. We investigated the anti‐fibrotic effect DHI its underlying mechanisms in vitro vivo . Experimental Approach Rats subjected to bile duct ligation (BDL) were treated with (25 mg·kg −1 ·day , i.p.) for 14 days. Serum biochemical liver tissue morphological analyses performed. The human hepatic stellate cell line LX‐2 served as...