A5070611989- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Social Media in Health Education
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Polyomavirus and related diseases
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Patient-Provider Communication in Healthcare
- Immune cells in cancer
- Mesenchymal stem cell research
- Eosinophilic Disorders and Syndromes
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
- Orthopaedic implants and arthroplasty
- Hematopoietic Stem Cell Transplantation
- Health Literacy and Information Accessibility
- Neurological Complications and Syndromes
- Full-Duplex Wireless Communications
- Histiocytic Disorders and Treatments
Cleveland Clinic
2020-2025
Cornell University
2019-2021
Weill Cornell Medicine
2019-2021
The University of Texas Southwestern Medical Center
2017-2019
Presbyterian Hospital
2019
New York Hospital Queens
2019
NewYork–Presbyterian Hospital
2019
University of Rochester
2017-2019
Johns Hopkins University
2014-2018
University of Rochester Medical Center
2017-2018
Bone formation was investigated in vitro by culturing stromal osteoblasts three-dimensional (3-D), biodegradable poly(DL-lactic-co-glycolic acid) foams. Three polymer foam pore sizes, ranging from 150-300, 300-500, and 500-710 microns, two different cell seeding densities, 6.83 x 10(5) cells/cm2 22.1 cells/cm2, were examined over a 56-day culture period. The foams supported the proliferation of seeded as well their differentiated function, demonstrated high alkaline phosphatase activity...
CBL proteins are a family of RING finger E3 ubiquitin ligases that regulate proliferative signals via ubiquitination and degradation tyrosine-phosphorylated signaling proteins, such as KIT, CSF-1, FLT3 PDGF [1].We previously described c-CBL mutations in myeloid neoplasia (MN), chiefly myelodysplastic/ myeloproliferative (MDS/MPN) syndromes chronic myelomonocytic leukemia [2, 3] juvenile [4].c-CBL mainly heterozygous, but some instances homozygous configuration can be found due to somatic...
Porous biodegradable poly(DL-lactic-co-glycolic acid) foams were seeded with rat marrow stromal cells and implanted into the mesentery to investigate in vivo bone formation at an ectopic site. Cells a density of 6.83 × 105 cells/cm2 onto polymer having pore sizes ranging from either 150 300 or 500 710 μm cultured for 7 days vitro prior implantation. The polymer/cell constructs harvested after 1, 7, 28, 49 processed histology gel permeation chromatography. Visual observation hematoxylin...
There is a rising interest in the use of social media by pathologists. However, pathology images on has been debated, particularly gross examination, autopsy, and dermatologic condition photographs. The immediacy interactions, increased from patients patient groups, fewer barriers to public discussion raise additional considerations ensure privacy protected. Yet these very features all add power for educating other physicians nonmedical about disease creating better understanding important...
We previously discovered a new osteogenic growth factor that is required to maintain adult skeletal bone mass, Osteolectin/Clec11a. Osteolectin acts on Leptin Receptor+ (LepR+) stem cells and other progenitors in marrow promote their differentiation into osteoblasts. Here we identify receptor for Osteolectin, integrin α11, which expressed by LepR+ α11β1 binds with nanomolar affinity the response Osteolectin. Deletion of Itga11 (which encodes α11) from mouse human stromal impaired blocked...
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this regulated. Here we found nerve growth factor (NGF) produced by leptin receptor-expressing (LepR+) stromal cells required to maintain fibres in adult marrow. In nerveless marrow, steady-state haematopoiesis was normal and vascular were impaired myeloablation. LepR+ cells, the adipocytes they gave rise to, increased NGF...
Bone formation was investigated in vitro by culturing stromal osteoblasts three-dimensional (3-D), biodegradable poly(DL-lactic-co-glycolic acid) foams. Three polymer foam pore sizes, ranging from 150–300, 300–500, and 500–710 μm, two different cell seeding densities, 6.83 × 105 cells/cm2 22.1 cells/cm2, were examined over a 56-day culture period. The foams supported the proliferation of seeded as well their differentiated function, demonstrated high alkaline phosphatase activity deposition...
Immunosuppression for solid organ transplantation increases lymphoproliferative disease risk. While central nervous system (CNS) involvement is more rare, we noticed an increase in primary CNS (PCNS) disease. To investigate a potential association with the immunosuppressive regimen identified all post-transplant (PTLD) cases diagnosed over 28-year period at our institution (174 total, 29 PCNS) and similar recorded United Network Organ Sharing-Organ Procurement Transplant (UNOS-OPTN)...
Traditionally low-grade B-cell lymphomas have been excluded from the category of monomorphic posttransplant lymphoproliferative disorders. However, recent reports identified Epstein-Barr virus-positive (EBV) extranodal marginal zone (MZL), almost exclusively seen in setting. Some reported cases responded to reduced immunosuppression, suggesting that they should be considered as a form We 10 EBV MZL, 9 sites and 1 presenting lymph node. Two arose following solid organ transplantation, but...
Abstract Studies of genetic blood disorders have advanced our understanding the intrinsic regulation hematopoiesis. However, such studies only yielded limited insights into how interactions between hematopoietic cells and their microenvironment are regulated. Here, we describe two affected siblings with infantile myelofibrosis myeloproliferation that share a common de novo mutation in Rho GTPase CDC42 (Chr1:22417990:C>T, p.R186C) due to paternal germline mosaicism. Functional using human...
Barth syndrome is an X-linked characterized by cardiomyopathy, skeletal myopathy, and neutropenia. This life-threatening disorder results from loss-of-function mutations in TAFAZZIN , which encodes a phospholipid-lysophospholipid transacylase located the mitochondria inner membrane. Decreased cardiolipin levels increased monolysocardiolipin perturb mitochondrial function. However, mechanism(s) leading to myopathies neutropenia are unknown, no currently effective therapy exists. To address...
Intravascular lymphomas are rare and aggressive hematolymphoid tumors. Here, we describe a human herpesvirus type-8 (HHV-8)/Kaposi sarcoma-associated herpesvirus-positive Epstein-Barr virus (EBV)-positive intravascular lymphoma. The patient was 59-year-old immunodeficiency virus-positive man who presented with diarrhea, abdominal pain, fevers, night sweats, weight loss. Radiographic studies of the abdomen pelvis revealed numerous subcentimeter nodules within subcutaneous fat that lacked...
Myeloproliferative neoplasm, unclassifiable (MPN-U, revised to MPN, not otherwise specified in the fifth edition of World Health Organization classification) is a heterogeneous category primary marrow disorders with clinical, morphologic, and/or molecular features that preclude classification as more specific MPN subtype due stage at diagnosis, overlapping between subtypes, or presence coexisting disorders. Compared other contribution mutational landscape MPN-U conjunction clinical and...