A5023531123- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mesenchymal stem cell research
- Zebrafish Biomedical Research Applications
- Sphingolipid Metabolism and Signaling
- Hematological disorders and diagnostics
- Single-cell and spatial transcriptomics
- Liver physiology and pathology
- Fibroblast Growth Factor Research
- Sepsis Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Bone and Joint Diseases
- Platelet Disorders and Treatments
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- CAR-T cell therapy research
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
Tel Aviv University
2024-2025
Sheba Medical Center
2024-2025
Cornell University
2017-2023
Weill Cornell Medicine
2017-2023
Howard Hughes Medical Institute
2021-2022
Weizmann Institute of Science
2011-2020
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How and its major byproduct lactate are triggered in bone marrow (BM) neutrophils contribution to neutrophil mobilization acute inflammation is not clear. Here we report that lipopolysaccharides (LPS) or Salmonella Typhimurium triggers release by increasing glycolysis, NADPH-oxidase-mediated reactive oxygen species HIF-1α levels BM neutrophils. Increased...
The liver vascular network is patterned by sinusoidal and hepatocyte co-zonation. How intra-liver vessels acquire their hierarchical specialized functions unknown. We study heterogeneity of hepatic cells during mouse development through functional single-cell RNA-sequencing. acquisition endothelial cell identity initiated early completed postnatally, originating from a pool undifferentiated progenitors at E12. peri-natal induction the transcription factor c-Maf critical switch for...
Abstract Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic arterial vessels such as the aorta of aorta-gonad-mesonephros region (AGM). To identify signals responsible for HSC formation, here we use single cell RNA-sequencing to simultaneously analyze transcriptional profiles AGM-derived transitioning HSCs, and endothelial which provide sufficient support maturation self-renewal. Pseudotemporal ordering reveals dynamics gene expression during transition,...
T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising diverse subtypes that are challenging to stratify using conventional immunophenotyping. To gain insights into subset-specific therapeutic vulnerabilities, we performed integrative multiomics analysis of bone marrow samples from newly diagnosed T cell ALL, early precursor and T/myeloid mixed phenotype leukemia. Leveraging cellular indexing transcriptomes epitopes in conjunction with receptor sequencing, identified...
Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is target effective therapies against breast cancer. In search for similarly targetable genomic aberrations, we identified copy number gains in SYNJ2, 5'-inositol lipid phosphatase synaptojanin 2, as well overexpression small fraction human tumors. Copy gain and correlated with shorter patient survival low abundance tumor suppressor microRNA miR-31. SYNJ2 promoted cell migration invasion culture...
Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemias. The rearrangements underlie generation fusion proteins acting as potent oncogenes. Several most consistently up-regulated targets fusions, MEIS1 , HOXA7, HOXA9, HOXA10 functionally related have been implicated other types Each four genes was knocked down separately human precursor B-cell leukemic line RS4;11 expressing MLL-AF4. mutant control cells were compared for engraftment NOD/SCID...