A5036085776- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Chronic Myeloid Leukemia Treatments
- Ubiquitin and proteasome pathways
- Cutaneous Melanoma Detection and Management
- Gene expression and cancer classification
- Advanced biosensing and bioanalysis techniques
University of Ferrara
2015-2025
University of Warsaw
2022-2025
The Ohio State University
2009-2023
Cancer Genetics (United States)
2005-2023
Weatherford College
2023
Center for Translational Neurophysiology of Speech and Communication
2021
The Ohio State University Wexner Medical Center
2009-2018
Virginia Commonwealth University
2014-2017
University Health Network
2017
Massachusetts General Hospital
2017
Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression are differentially expressed in normal tissues cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, pancreatic tumors, we identified solid miRNA signature composed by large portion of overexpressed miRNAs. Among these miRNAs some with well characterized association, such as miR-17-5p , miR-20a miR-21 miR-92 miR-106a miR-155 . The predicted targets...
Abstract MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant may be involved in human diseases, including cancer. Indeed, miRNA has been previously found chronic lymphocytic leukemias, where signatures were associated with specific clinicobiological features. Here, we show that, compared normal breast tissue, miRNAs also aberrantly expressed The overall could...
Chronic lymphocytic leukemia (CLL) is the most common human and characterized by predominantly nondividing malignant B cells overexpressing antiapoptotic cell lymphoma 2 (Bcl2) protein. miR-15a miR-16-1 are deleted or down-regulated in majority of CLLs. Here, we demonstrate that expression inversely correlated to Bcl2 CLL both microRNAs negatively regulate at a posttranscriptional level. BCL2 repression these induces apoptopsis leukemic line model. Therefore, miR-15 miR-16 natural antisense...
MicroRNA expression profiles can be used to distinguish normal B cells from malignant in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA are associated known prognostic factors CLL.We evaluated the of 94 samples CLL for which level 70-kD zeta-associated protein (ZAP-70), mutational status rearranged immunoglobulin heavy-chain variable-region (IgV(H) ) gene, and time diagnosis initial treatment were known. also genomic sequence 42 genes identify...
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles miRNAs in carcinogenesis. We and others have shown profiles different lung cancer vs. normal lung, although the significance this aberrant is poorly understood. Among reported down-regulated cancer, miRNA (miR)-29 family (29a, 29b, 29c) has intriguing complementarities to 3'-UTRs DNA methyltransferase (DNMT)3A -3B (de novo methyltransferases), two key enzymes involved...
Abstract Epithelial ovarian cancer (EOC) is the sixth most common in women worldwide and, despite advances detection and therapies, it still represents lethal gynecologic malignancy industrialized countries. Unfortunately, relatively little known about molecular events that lead to development of this highly aggressive disease. The recent discovery microRNAs (miRNA), a class small noncoding RNAs targeting multiple mRNAs triggering translation repression and/or RNA degradation, has revealed...
Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs (miRNAs) are transcriptionally up-regulated PTC tumors compared with unaffected tissue. A set five miRNAs, including three most ones (miR-221, -222, and -146), distinguished unequivocally between normal thyroid. Additionally, miR-221 was tissue several patients, presumably an early event carcinogenesis. Tumors which...
While global microRNA (miRNA) expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description the role miRNAs in ductal adenocarcinoma pancreas is lacking.To define pattern pancreatic cancer compare it with those normal chronic pancreatitis.Specimens were obtained at a National Cancer Institute-designated comprehensive center from patients (n = 65) or pancreatitis 42) (January 2000-December 2005). All underwent curative pancreatectomy;...
MicroRNAs (miRNAs) represent a newly discovered class of posttranscriptional regulatory noncoding small RNAs that bind to targeted mRNAs and either block their translation or initiate degradation. miRNA profiling hematopoietic lineages in humans mice showed some miRNAs are differentially expressed during development, suggesting role cell differentiation. In addition, recent studies suggest the involvement initiation progression cancer. miR155 BIC, its host gene, have been reported accumulate...
MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of transcripts, but only few have experimental validation. In chronic lymphocytic leukemia (CLL), the most common adult leukemia, miR-15a and miR-16-1 lost or down-regulated majority cases. After our previous work indicating a tumor suppressor function miR-15a/16-1 by targeting BCL2 oncogene, here, we produced high-throughput...
We investigated the global microRNA expression patterns in normal pancreas, pancreatic endocrine tumors and acinar carcinomas to evaluate their involvement transformation malignant progression of these tumor types. MicroRNAs are small noncoding RNAs that regulate gene by targeting specific mRNAs for degradation or translation inhibition. Recent evidence indicates microRNAs can contribute development may have diagnostic prognostic value several human malignancies.Using a custom microarray, we...
MicroRNAs are small noncoding RNAs that regulate the expression of protein-coding genes. To evaluate involvement microRNAs in prostate cancer, we determined genome-wide and mRNAs 60 primary tumors 16 nontumor tissues. The mRNA analysis revealed key components microRNA processing several host genes, e.g., MCM7 C9orf5, were significantly up-regulated tumors. Consistent with these findings, expressed miR-106b-25 cluster, which maps to intron 13 MCM7, miR-32, 14 at higher levels than prostate....
MicroRNA (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Expression patterns miRNAs their role in the pathogenesis hepatocellular carcinoma (HCC) still poorly understood. We profiled miRNA tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) well 35 HCC cell lines. A set 12 (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, let-7c) was linked to disease progression from liver through cirrhosis...
Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and the regulation of protein sorting yeast. Receptors with intrinsic associated tyrosine recruit heterodimeric phosphoinositide-3 kinases that consist p110 catalytic subunits p85 adaptor molecules containing Src homology 2 (SH2) domains. A isotype, p110γ, was cloned characterized. The p110γ enzyme activated vitro both α βγ heterotrimeric guanosine triphosphate...
Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery microRNAs (miRNAs), class small noncoding RNAs targeting mRNAs, revealed new level gene expression regulation. To determine whether miRNAs play role malignant transformation cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile MM-derived lines ( n = 49) CD138+ bone marrow PCs from subjects with MM 16), monoclonal gammopathy undetermined...