A5084643930- Renal and related cancers
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Pluripotent Stem Cells Research
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Advanced Proteomics Techniques and Applications
- Probiotics and Fermented Foods
- Circadian rhythm and melatonin
- Drug Transport and Resistance Mechanisms
- Electrolyte and hormonal disorders
- Hematopoietic Stem Cell Transplantation
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Microbial Metabolites in Food Biotechnology
- CRISPR and Genetic Engineering
- Peroxisome Proliferator-Activated Receptors
- Cancer therapeutics and mechanisms
- Educational Reforms and Innovations
- High Altitude and Hypoxia
- Organ Transplantation Techniques and Outcomes
- Trace Elements in Health
- Neurogenesis and neuroplasticity mechanisms
Medical University of Warsaw
2017-2024
University of Louisville
2022
University of Warsaw
2018
West Pomeranian University of Technology
2011-2014
Abstract Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin–angiotensin–aldosterone system (RAAS) in regulating conversion angiotensin II (Ang II) into (1–7) [1–7]). But at same time, while expressed on surface human cells, ACE2 is entry receptor for SARS-CoV-2. Expression this has been described several types including hematopoietic stem cells (HSCs) and endothelial progenitor (EPCs), which raises concern that virus may infect damage cell compartment. We...
Surfactant protein C (SPC), a key component of pulmonary surfactant, also plays role in regulating inflammation. SPC deficiency patients and mouse models is associated with increased inflammation delayed repair, but the drivers SPC-regulated response to injury are largely unknown. This study focuses on new mechanism as an anti-inflammatory molecule using SPC-TK/SPC-KO (surfactant C-thymidine kinase/surfactant knockout) mice, which represent novel sterile model that mimics clinical acute...
1. Arriga R., Pacifici F., Capuani B. et al., 2019. Peroxiredoxin 6 is a key antioxidant enzyme in modulating the link between glycemic and lipogenic metabolism. Oxid. Med. Cell. Longev. 2019, 9685607, https://doi.org/10.1155/2019/9.... CrossRef Google Scholar
Abstract Proliferation, metabolism, and migration of hematopoietic stem/progenitor cells (HSPCs) are coordinated by receptors expressed on outer cell membranes that integrated into microdomains, known as membrane lipid rafts (MLRs). These structures float freely in the bilayer enriched cholesterol sphingolipids for their functional integrity. Receptors, if MLRs, have prolonged occupancy surface enhanced signaling power. Based this, we become interested regulation synthesis MLRs components...
Abstract We found that circadian changes in ATP level peripheral blood (PB) activate the Nlrp3 inflammasome, which triggers diurnal release of hematopoietic stem/progenitor cells (HSPCs) from murine bone marrow (BM) into PB. Consistent with this finding, we observed expression mRNA for inflammasome-related genes, including Nlrp3, caspase 1, IL-1β, IL-18, gasdermin (GSDMD), HMGB1, and S100A9. Circadian HSPCs BM PB as well Nlrp3-associated genes was decreased mice pannexin 1-mediated secretion...
Background: Alveolar type 2 (AT2) cells and bronchioalveolar stem (BASC) perform critical regenerative functions in response to lung damage. Published data show that nonhematopoietic, bone marrow-derived “very small embryonic-like cells” (VSELs) can differentiate vivo into surfactant protein C (SPC)-producing AT2 the lung. Here, we test directly whether VSEL-derived BASC function produce differentiated progeny. Methods: using a reporter mouse which H2B-GFP fusion is driven from murine SPC...
To assess cytotoxic effect of ciprofloxacin conjugates with fatty acids on prostate cancer cells (LNCaP and DU-145) different hormone sensitivity, based previous promising results from the PC3 cells. Cytotoxicity were estimated using MTT LDH tests, whereas its mechanisms by apoptosis IL-6 assays. The intensity proteins involved in lipid metabolism was determined ML-CS assay. insensitive DU-145 more vulnerable than sensitive LNCaP IC50 values for oleic (4), elaidic (5) docosahexaenoic acid...
Aquaporin 2 (AQP2) is a small, integral tetrameric plasma membrane protein that expressed in mammalian kidneys. The specific constitution of this and its selective permeability to water means AQP2 plays an important role hypertonic urine production. Immunolocalization has been studied humans, monkeys, sheep, dogs, rabbits, rats, mice adult cattle. We analyzed the expression kidneys 7-month-old Polish-Friesian var. black white male calves. was localized principal cells collecting ducts...
Abstract We reported in the past that activation of third (C3) and fifth element (C5) complement cascade (ComC) is required for a proper homing engraftment transplanted hematopoietic stem/progenitor cells (HSPCs). Since myeloablative conditioning transplantation triggers recipient bone marrow (BM) state sterile inflammation, we have become interested role this process potential involvement alternative pathway ComC activation. noticed factor B deficient mice (FB-KO) do not activate properly...
SARS-CoV-2 infection leads to severe lung damage due pneumonia and, in more cases, acute respiratory distress syndrome, or ARDS. This affects the viability of bronchoalveolar cells. An important role pathogenesis these complications is hyperactivation renin-angiotensin-aldosterone (RAA) pathway and induction cytokine storm that occurs an Nlrp3 inflammasome-dependent manner. To shed light on susceptibility tissue infection, we evaluated murine bronchioalveolar stem cells (BASC), alveolar type...
Very small embryonic like stem cells (VSELs) are a dormant population of that, as proposed, deposited during embryogenesis in various tissues, including bone marrow (BM). These released under steady state conditions from their tissue locations and circulate at low level peripheral blood (PB). Their number increases response to stressors well tissue/organ damage. This increase is evident neonatal delivery, delivery stress prompts enrichment umbilical cord (UCB) with VSELs. could be purified...
Abstract: The structural proteins of renal tubular epithelial cells may become a target for the toxic metabolites immunosuppressants. These can modify properties proteins, thereby affecting cell function, which is possible explanation mechanism immunosuppressive agents' toxicity. In our study, we evaluated effect two strategies on protein expression in kidneys Wistar rats. Fragments rat were homogenized after cooling liquid nitrogen and then dissolved lysis buffer. concentration samples was...
Very small embryonic-like stem cells (VSELs) are a dormant population of development early deposited in adult tissues that as demonstrated contribute to tissue/organ repair and regeneration. We postulated developmental relationship these migrating primordial germ (PGCs) explained the quiescent state by erasure differently methylated regions (DMRs) at some paternally imprinted genes involved embryogenesis. Recently, we reported VSELs began proliferate expand vivo murine bone marrow (BM) after...
The aim of the study was to evaluate effect selected polyphenolic compounds: epicatechin, apigenin, and naringenin, administered separately or in combination with zinc (Zn), on growth development neoplastic process induced by 7,12-dimethylbenz[a]anthracene (DMBA) rats. impact supplementation above-mentioned compounds content modified derivatives: 1-methyladenosine, N6-methyl-2'-deoxyadenosine, O-methylguanosine, 7-methylguanine, 3-methyladenine, 1-methylguanine, 2-amino-6,8-dihydroxypurine,...
The liver, as the main metabolic organ, plays a key role in many vital processes, including nutrient metabolism, fat digestion, blood protein synthesis, and endocrine management. As one of immune organs, it has remarkable ability to adequately activate cells response signals. anatomy liver ensures its close interaction with gut so that nutrients microbiota contribute normal metabolism. In chickens, intestinal an important supporting health improving production parameters. most effective...
Michałek, K., Dratwa-Chałupnik, A., Ciechanowicz, A. K. and Malinowski, E. 2014. Aquaporin 2: Identification analysis of expression in calves’ urine during their first month life. Can. J. Anim. Sci. 94: 653–659. 2 (AQP2) is a vasopressin-regulated water channel the renal collecting duct excreted into urine. Renal excretion AQP2 has been studied humans, dogs, rats mice. The aim this study was to identify analyze Short controlled diarrhea induced calves order determine any change evaluate...
Prebiotics are known to have many beneficial effects on intestinal health by modulating the gut microbiota composition, thereby affecting epithelial cell proliferation and metabolism. This study had two aims: (1) identify protein constituents in cecal mucosa of 50-day-old healthy (PIC × Penarlan P76) barrows, (2) assess 4% inclusion dried chicory root a cereal-based diet proteome changes. Pigs (eight per group) were randomly allotted groups fed control from tenth day life (C) or supplemented...