A5057540049- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal complexes synthesis and properties
- Cancer therapeutics and mechanisms
- Crystallography and molecular interactions
- HIV/AIDS drug development and treatment
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Chemical Reaction Mechanisms
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Quinazolinone synthesis and applications
- Crystal structures of chemical compounds
- Parkinson's Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Chemical Synthesis and Analysis
- Alzheimer's disease research and treatments
- Nonlinear Optical Materials Research
- Receptor Mechanisms and Signaling
Medical University of Warsaw
2016-2025
Medical University of Lublin
2017
Maria Curie-Skłodowska University
2007
Marie Curie
2007
Progressive Supranuclear Palsy (PSP) is an atypical parkinsonism. Major subtypes of the disease: PSP-Richardson's Syndrome (PSP-RS) and PSP Parkinsonism Predominant (PSP-P) vary in clinical features, pathomechanism remains unexplored. The aim this work to analyze relevance glial cell line-derived neurotrophic factor (GDNF) evaluation serum cerebrospinal fluid (CSF) verify its significance as a possible vivo examination. Authors assessed concentration GDNF CSF 12 patients with PSP-RS, PSP-P...
Ciprofloxacin (CP) has a confirmed cytotoxic action on some cancerous cells, but in high, non-pharmacological concentrations. Considering features of natural fatty acids, such as biocompatibility, biodegradability and their increased cellular uptake by cancer it seems that combining them with drug could improve its bioavailability, thus cytotoxicity. Therefore, the aim this study was coupling CP saturated unsaturated evaluation cytotoxicity, apoptosis-inducing effects inhibition IL-6 release...
To assess whether end-ischemic hypothermic oxygenated machine perfusion (HOPE) is superior to static cold storage (SCS) in preserving livers procured from donors after brain death (DBD).There increasing evidence of the benefits HOPE liver transplantation, but predominantly setting high-risk donors.In this randomized clinical trial, DBDs were randomly assigned either dual for at least 2 hours or SCS (1:3 allocation ratio). The Model Early Allograft Function (MEAF) was primary outcome measure....
Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome based on tau pathology; its clinical phenotype differs, but PSP with Richardson's (PSP-RS) and the parkinsonism predominant (PSP-P) variant remain two most common manifestations. Neuroinflammation involved in course of disease may cause neurodegeneration. However, up-to-date cytokine profile has not been assessed different phenotypes. This study aimed to evaluate possible differences neuroinflammatory patterns between...
A series of new thiourea derivatives 1,3-thiazole have been synthesized. All obtained compounds were tested in vitro against a number microorganisms, including Gram-positive cocci, Gram-negative rods and Candida albicans. Compounds also for their tuberculostatic activity the Mycobacterium tuberculosis H37Rv strain, as well two 'wild' strains isolated from patients. 3 9 showed significant inhibition cocci (standard hospital strain). The range MIC values is 2–32 µg/mL. Products effectively...
A series of 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation 2-(1H-indol-3-yl)ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media. The structures the newly synthesized compounds confirmed spectroscopic analysis and molecular 8 28 X-ray crystallography. All obtained tested for antimicrobial activity against Gram-positive cocci, Gram-negative rods antifungal activity. Microbiological evaluation was carried out over 20 standard strains 30 hospital...
A novel series of N-acylated ciprofloxacin (CP) conjugates 1-21 were synthesized and screened as potential antimicrobial agents. Conjugates 1 2 1.25-10-fold more potent than CP toward all Staphylococci (minimal inhibitory concentration 0.05-0.4 μg/mL). Most the chloro- (3-7), bromo- (8-11), CF3-alkanoyl (14-16) derivatives expressed higher or comparable activity to against selected Gram-positive strains. few analogues (5, 10, 11) also effective chosen clinical Gram-negative rods. 5, 11...
Progressive Supranuclear Palsy is an atypical parkinsonism based on tauopathic pathology. Growing interest associated with the pathomechanism of this disease. Among theories analyzing issue can be mentioned one highlighting significance inflammation. In study authors examined 14 patients PSP-Richardson syndrome (PSP-RS) and 13 healthy volunteers using laboratory testing analysis interleukins 1 6 (IL-1 IL-6), tau in cerebrospinal fluid (CSF) non-specific parameters peripheral inflammation...
The treatment of infectious diseases is a challenging issue faced by the medical community. emergence drug-resistant strains bacteria and fungi major concern. Researchers professionals are working to develop new innovative treatments for diseases. Schiff bases one promising class compounds. In this work, derivatives were obtained 4-amino-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione reaction, with corresponding benzaldehydes various substituents at position 4. antibacterial...
Phenothiazine derivatives are widely studied in various fields such as biology, chemistry, and medicine research because of their pharmaceutical effects. The first compound used successfully the treatment psychosis was a phenthiazine derivative, chlorpromazine. Apart from its activity neurons, chlorpromazine has also been reported to display anticancer antibacterial properties. In this study, we present synthesis on A549, MDA, MiaPaCa, PC3, HCT116 cancer cell lines S. aureus, epidermidis, E....
A series of nineteen new thiourea and urea derivatives 10-isopropyl-8-methyl-4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione, 1-isopropyl-7-methyl-4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione 1,7,8,9,10-pentamethyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared studied by 1H-NMR. The compound k1a (1-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-3-phenyl-urea) was tested for pharmacological activity on animal central nervous system (CNS)....
Background: Hypothermic oxygenated machine perfusion has emerged as a strategy to alleviate ischemic-reperfusion injury in liver grafts. Nevertheless, there is limited data on the effectiveness of hypothermic evaluating organ quality. This study aimed introduce readily accessible real-time predictive biomarker measured perfusate for post-transplant graft function. Methods: The evaluated analytes over 90-day postoperative period 26 patients randomly assigned receive following dual prospective...
Background: Research has associated chronic inflammation with the evolution of neurological and psychiatric disorders. Neurodegenerative diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), less common ones such as Progressive Supranuclear Palsy (PSP), are commonly linked to depression. However, pathomechanisms role neuroinflammation in these disorders remain unclear; therefore, interest is increasing easily accessible inflammatory morphological assessments blood samples,...
This study examines the synthesis and biological evaluation of novel tetrazole derivatives 3,3'-dimethoxybenzidine as potential anticancer agents, focusing on their cytotoxic, apoptotic, anti-inflammatory properties. Ten were synthesized using thioureas precursors, characterized through spectroscopic methods, assessed for in silico toxicological profiles ADMET-AI ProTox 3.0 platforms. In vitro cytotoxic activity was evaluated against four human cancer cell lines (HTB-140, A549, HeLa, SW620)...
Abstract Doxorubicin (DOX) is a leading cytostatic drug with many adverse effects in use. We are still looking for methods that will allow us to preserve the therapeutic effect against tumor cells and reduce toxicity normal cells. In our work, we obtained amide derivatives of DOX by reaction amino group α-linolenic (LNA) docosahexaenoic (DHA) acids ( 2 , 3 ), as well double-substituted via ester linkages 4 5 ). The structures compounds were confirmed Proton Nuclear Magnetic Resonance (1H...