A5084812069- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Organ Donation and Transplantation
- Abdominal Surgery and Complications
- Diverticular Disease and Complications
- Clinical Nutrition and Gastroenterology
- Intraperitoneal and Appendiceal Malignancies
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
Medical University of Warsaw
2016-2025
1 Military Clinical Hospital with Outpatient Clinic
2024
Institute Mutualiste Montsouris
2019-2020
Université Paris Cité
2019-2020
Délégation Paris 5
2019
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures been interrupted delayed because COVID-19 pandemic.An international survey impact on clinical practice trials from March 2020 June 2020, as first phase a multicentre, international, observational project. focus was hepatocellular carcinoma intrahepatic...
To assess whether end-ischemic hypothermic oxygenated machine perfusion (HOPE) is superior to static cold storage (SCS) in preserving livers procured from donors after brain death (DBD).There increasing evidence of the benefits HOPE liver transplantation, but predominantly setting high-risk donors.In this randomized clinical trial, DBDs were randomly assigned either dual for at least 2 hours or SCS (1:3 allocation ratio). The Model Early Allograft Function (MEAF) was primary outcome measure....
Abstract Transarterial chemoembolization (TACE) represent the standard of therapy for non-operative hepatocellular carcinoma (HCC), while prediction long term treatment outcomes is a complex and multifactorial task. In this study, we present novel machine learning approach utilizing radiomics features from multiple organ volumes interest (VOIs) to predict TACE 252 HCC patients. Unlike conventional models requiring laborious manual segmentation limited tumoral regions, our captures...
Abstract Laparoscopic appendectomy (LA) for treatment of acute appendicitis has gained acceptance with its considerable benefits over open appendectomy. LA, however, can involve some adverse outcomes: morbidity, prolonged length hospital stay (LOS) and readmission. Identification predictive factors may help to identify tailor patients higher risk these events. Our aim was serious LOS readmission after LA. A database compiled information admitted from eighteen Polish German surgical centers....
Serum α-fetoprotein concentration (AFP) might be a useful addition to morphologic criteria for selecting patients with hepatocellular carcinoma (HCC) liver transplantation (LT). The aim of this study was evaluate the role AFP in HCC at minimal risk posttransplant tumor recurrence setting existing criteria.This retrospective cohort based on 121 after LT performed single institution. evaluated as predictor respect fulfillment Milan, University California, San Francisco (UCSF), and Up-to-7...
Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) poor recurrence-free (RFS) for patients who underwent perihilar cholangiocarcinoma (pCCA). However, the prognostic value lymph nodes independently from margin status on OS has not evaluated. Methods: From European Cholangiocarcinoma (ENSCCA) registry, pCCA between 1994 2021 were included in this retrospective cohort study. The primary outcome was stratified...
Background: Hypothermic oxygenated machine perfusion has emerged as a strategy to alleviate ischemic-reperfusion injury in liver grafts. Nevertheless, there is limited data on the effectiveness of hypothermic evaluating organ quality. This study aimed introduce readily accessible real-time predictive biomarker measured perfusate for post-transplant graft function. Methods: The evaluated analytes over 90-day postoperative period 26 patients randomly assigned receive following dual prospective...
Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset resulting late diagnosis. Currently, no robust diagnostic biomarker clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening hepatobiliary differentiation.Serum EVs hepatocellular carcinoma, colorectal non-small cell lung patients, well from healthy individuals, were...
The number of elderly patients undergoing liver transplantation (LT) is increasing worldwide. aim the study was to evaluate impact recipient age exceeding 60 years on early and long-term outcomes after LT.This comprised data 786 primary LT performed at a single center between January 2005 October 2012. Patients over under were compared with respect baseline characteristics outcomes: postoperative mortality (90-day) 5-year patient (PS) graft (GS) survival. Associations results assessed in...
Abstract Background The gut microbial ecosystem plays an important role in the pathogenesis of liver diseases. However, association community structure with severity dysfunction is not completely understood. Methods Fecal microflora was assessed 40 patients cirrhosis listed for primary transplantation ( LT ). Independent associations between fecal counts and serum bilirubin, creatinine, international normalized ratio INR ), Model End‐stage Liver Disease MELD ) score were established multiple...
Transarterial chemoembolization (TACE) induces ischemic tumor necrosis, which is intensified by regional chemotherapy. By reducing the active tissue, it can be assumed that patients on waiting list for liver transplantation may benefit from this locoregional treatment. The aim of study was to assess relevance TACE in hepatocellular carcinoma (HCC) before transplantation.A retrospective analysis performed data 229 who were transplanted HCC. A group 75 treated with prior transplantation. Tumor...
Data on routine hypothermic machine perfusion of livers procured from donors after brain death (DBD) are scarce, and the benefits method have only been demonstrated in extended criteria grafts. The aim this study was to assess if end-ischemic dual oxygenated (dHOPE) is superior static cold storage (SCS) preservation DBD with respect long-term outcomes. Existing data short-term outcomes favours dHOPE patients receiving high-risk
Acute appendicitis (AA) is the most common surgical emergency and can occur at any age. Nearly all of studies comparing outcomes appendectomy between younger older patients set cut-off point 65 years. In this multicenter observational study, we aimed to compare laparoscopic for AA in various groups with particular interest elderly very comparison adults.Our study 18 units assessed 4618 appendectomies AA. Patients were divided 4 according their age: Group 1-<40 years old; 2-between 40 64...
Abstract Background This study was conducted to evaluate the predisposing factors, microbiology, treatment, and outcomes associated with hepatic abscess, a rare but serious complication which may accur after an orthotopic liver transplant ( OLT ). Methods retrospective based on prospectively maintained database of 1100 patients who underwent at Medical University Warsaw. An abscess defined imaging as solitary or multiple localized parenchymal collections in clinical signs infection, without...
This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy liver tumors of all dignities.
Background: The need for safe and efficient dissemination of minimally invasive approach in liver surgery is among the current challenges hepatobiliary surgeons. After stage innovators pioneers, following countries should adopt a laparoscopic approach. aim this study was to assess national experience trend implementing resection (LLR) Poland. Materials Methods: A registry LLR performed Poland established June 2020. All cases before were included retrospectively, followed by prospectively...
BACKGROUND Acute liver failure (ALF) remains a critical concern, accounting for about 8% of all transplants, with acetaminophen overdose contributing to nearly half these cases. Besides synthetic toxins, natural toxins such as phallotoxin from Amanita phalloides mushrooms also lead severe hepatocyte damage. This study investigates the outcomes transplantation (LT) life-saving intervention in patients suffering ALF due and poisoning. MATERIAL AND METHODS We conducted retrospective analysis 39...