A5003001023- Coccidia and coccidiosis research
- Veterinary medicine and infectious diseases
- Antimicrobial Peptides and Activities
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- X-ray Diffraction in Crystallography
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Crystallization and Solubility Studies
- Mass Spectrometry Techniques and Applications
- T-cell and B-cell Immunology
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Chemical Reactions and Isotopes
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Cancer therapeutics and mechanisms
- Enzyme function and inhibition
- Insect and Pesticide Research
- Metal complexes synthesis and properties
- Metal and Thin Film Mechanics
- Advanced Chemical Physics Studies
- Immunotherapy and Immune Responses
Adam Mickiewicz University in Poznań
2019-2025
Glioblastoma (GBM) remains the most frequently diagnosed primary malignant brain cancer in adults. Despite recent progress understanding biology of GBM, clinical outcome for patients poor, with a median survival approximately one year after diagnosis. One factor contributing to failure trials is fact that traditional models used GBM drug discovery poorly recapitulate patient tumors. Previous studies have shown monensin (MON) analogs, namely esters and amides on C-26 were potent towards...
Objectives/Goals: Monensin is FDA approved for use in veterinary medicine. Recent studies pointed to its potent anticancer activity. Since de novo drug discovery process typically takes 10 15 years and requires an investment of approximately $1.3 $3 billion, repositioning can bypass several steps this increase the potential success. Methods/Study Population: Cell viability assays were conducted on human MDA-MB-231, MDA-MB-468, MCF10A breast cancer cell lines mouse EO771 4T1 lines. MDA-MB-231...
Abstract Background: Our previous data revealed that K+/Na+ cation carriers, including salinomycin, robustly upregulate CD20 antigen levels on the surface of malignant B cells via suppression c-Myc and FOXO, two negative transcriptional regulators expression (Torun et al., 2024 Haematologica). The therapeutic efficacy anti-CD20 monoclonal antibodies (mAbs) against depends, among other factors, expression. Therefore, treatment with leading to upregulation, translates more efficient...
In recent years salinomycin has emerged as a promising anticancer drug. Many literature reports have proved its remarkable antiproliferative activity. Moreover, chemical modifications of lead to analogues with even higher cytotoxicity against cancer cell lines and better selectivity index for malignant cells than those the unmodified compound or standard drug such doxorubicin. this paper we report synthesis series twelve novel conjugates their characterization by spectroscopic spectrometric...
Combretastatins isolated from the Combretum caffrum tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt polymerization process microtubules in tubulins, causing mitotic arrest. In vitro and vivo studies have proven that some combretastatins exhibit antitumor properties, among them, combretastatin A-4 is most active inhibitor. this study, series novel analogs containing carboxylic acid, ester, amide moieties were synthesized their...
Salinomycin (SAL), a polyether antibiotic exerting K+/H+-exchange on cellular membranes, effectively kills cancer stem cells. A series of cationic triphenylphosphonium (TPP+)-linked SAL derivatives were synthesized aiming to render them mitochondria-targeted. Remarkably, attaching TPP+ moiety via triazole linker at the C-20 position (compound 5) preserved ion carrier potency antibiotic, while analogs with linked C-1 (6, 8) ineffective. On planar bilayer lipid membranes (BLM), 6 and 8...
Salinomycin (SAL), a monocarboxylic polyether antibiotic isolated from Streptomyces albus is widely used in veterinary medicine as growth promoter and supplement poultry feed to control infection with coccidia. SAL exhibits also potent activity against the proliferation of various cancer cells, including those that display multidrug resistance (MDR), can precisely kill stem cells (CSCs). The compound 2 – product acidic degradation has been structurally characterized by X-ray, FT-IR, NMR, DFT...
OBJECTIVES/GOALS: Although the approval of immune checkpoint inhibitors (ICIs) revolutionized treatment metastatic breast cancer (BC), yet about 30% remain unresponsive. Since potency ICIs depends on efficient presentation tumor-specific antigens by cells, compounds which increase such could efficacy ICIs. METHODS/STUDY POPULATION: A library ester and urethane derivatives polyether ionophore antibiotic, monensin (MON) has been synthesized. MTT cell viability assays were performed panel human...
Monensin succinate ester hydrate (2-H2O) has been synthesized by the succinylation of C-26 hydroxyl group monensin (1) using a simple reaction with succinic anhydride. Additionally, sodium salt (2-Na) obtained. Molecular structures both compounds (2-H2O and 2-Na) were studied X-ray diffraction single crystals spectroscopic methods. According crystallographic studies 2-H2O 2-Na, molecules are held together as dimers linked centrosymmetric pairs intermolecular hydrogen bonds between carboxylic...
<b>Abstract ID 97781</b> <b>Poster Board 285</b> The recent approval of immune checkpoint inhibitors (ICIs) has revolutionized the treatment metastatic breast cancer (BC). However, approximately 30% patients remain unresponsive. effectiveness ICIs depends on effective presentation tumor-specific antigens by cells. Consequently, augmenting this holds potential to enhance efficacy ICI treatment. Monensin (MON), a naturally occurring ionophore antibiotic with anti-cancer properties, emerges as...
Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group potassium/sodium cation carriers) robustly enhance surface expression CD20 antigen in B-cell-derived tumor cells, including primary malignant cells chronic lymphocytic leukemia diffuse large B-cell lymphoma. Experiments vitro, ex vivo, animal model reveal a novel approach combining salinomycin or monensin with therapeutic anti-CD20 monoclonal antibodies CAR-T significantly...
<b>Abstract ID 15572</b> <b>Poster Board 552</b> Over the last 30 years, incidences of melanoma have increased dramatically. Although, accounts only for approximately one percent skin cancers, it is responsible almost eighty all deaths from dermatological malignancies. Current therapeutic approaches vary depending on tumor progression and patient's health, include removal, immunotherapy, forms targeted therapy. Major limitations in treating are associated with adverse side effects treatments...
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite numerous clinical trials, standard of care therapy has remained unchanged for last decade. One main problems contributing to limited effective treatment options and poor overall survival lack models which can reliably recapitulate heterogeneity. Organoids are 3D self-organized structures mimic architecture, microenvironment, cellular interactions makes them an improved model anti-cancer drug discovery....