A5016033983- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal and related cancers
- Cancer Cells and Metastasis
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- T-cell and B-cell Immunology
- Infant Nutrition and Health
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Organ Donation and Transplantation
- Microbial Natural Products and Biosynthesis
- HIV/AIDS drug development and treatment
- bioluminescence and chemiluminescence research
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Pluripotent Stem Cells Research
Medical University of Warsaw
2023-2025
University of Gdańsk
2023
Gdańsk Medical University
2023
SciencePharma (Poland)
2023
Gdańsk University of Technology
2023
University of Oslo
2023
Abstract Background: Our previous data revealed that K+/Na+ cation carriers, including salinomycin, robustly upregulate CD20 antigen levels on the surface of malignant B cells via suppression c-Myc and FOXO, two negative transcriptional regulators expression (Torun et al., 2024 Haematologica). The therapeutic efficacy anti-CD20 monoclonal antibodies (mAbs) against depends, among other factors, expression. Therefore, treatment with leading to upregulation, translates more efficient...
Hematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, leading cause of mortality in patients. To address this critical issue, we explored novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin (CIP) or levofloxacin (LVX), the cell-penetrating peptide transportan 10...
The fusion of penetrating peptides (PPs), e.g., cell penetration (CPPs), or antimicrobial (AMPs) together with agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, well valuable anticancer proving beneficial in the development conjugates. resulting conjugates offer potential dual functionality, acting both agent. This especially necessary cancer treatment where microbial...
Very Small Embryonic-like Stem Cells (VSELSCs) and Cancer (VSCSCs) are fields of intensive research. Although the presence in vitro VSELSC VSCSC cellular stage analogs appear probable, it has yet to be published. Utilizing established human cell cultures with varying populations primitive cells, stained CD markers specific stages, addition a fluorescent DNA dye, following histochemical processing, we have developed cytological method for detecting Leukemic Stem-like (VSLSLCs), (VSCSLCs),...
Abstract Resistance of tumor cells to immunotherapy with monoclonal antibodies (mAbs) often relies on the reduced level antigen targeted by particular mAb. We have therefore screened for compounds able upregulate selected antigens surface lymphoma/leukemia cells, minimize possibility resistance acquired cells. found that members a specific class antibiotics, known as cation carriers, namely salinomycin (SAL), monensin (MON), narasin, and nigericin exhibit great CD20 antigen-upregulating...
Liver transplantation is a critical and evolving field in modern medicine, offering life-saving treatment for patients with end-stage liver disease other hepatic conditions. Despite its transformative potential, faces persistent challenges, including global organ shortage, increasing prevalence, significant waitlist mortality rates. Current donor evaluation practices often discard potentially viable livers, underscoring the need refined graft assessment tools. This review explores...
The fusion of penetrating peptides (PPs) e.g., cell penetration (CPP) or antimicrobial (AMPs) together with aniti-micriobial agents is an expanding research field. Specific AMPs, such as Lactoferricin B (LfcinB), have demonstrated strong antibacterial, anti-fungal and antiparasitic activity, well valuable anticancer proving beneficial in the development conjugates. resulting conjugates offer potential dual functionality, acting both agent. This particularly important treating leukemia...
The fusion of penetrating peptides (PPs), e.g., cell penetration (CPPs) or antimicrobial (AMPs), together with agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, well valuable anticancer proving beneficial in the development conjugates. resulting conjugates offer potential dual functionality, acting both agent. This especially necessary cancer treatment, where microbial...
Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group potassium/sodium cation carriers) robustly enhance surface expression CD20 antigen in B-cell-derived tumor cells, including primary malignant cells chronic lymphocytic leukemia diffuse large B-cell lymphoma. Experiments vitro, ex vivo, animal model reveal a novel approach combining salinomycin or monensin with therapeutic anti-CD20 monoclonal antibodies CAR-T significantly...