A5054777821- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Cancer Treatment and Pharmacology
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Stress Responses and Cortisol
- Cancer, Stress, Anesthesia, and Immune Response
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Plant-based Medicinal Research
- Complementary and Alternative Medicine Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Management and Opioid Use
- Nerve injury and regeneration
- Asthma and respiratory diseases
- Vagus Nerve Stimulation Research
- Sexual function and dysfunction studies
- Pain Management and Placebo Effect
- Exercise and Physiological Responses
- Biochemical effects in animals
- Trigeminal Neuralgia and Treatments
- Spine and Intervertebral Disc Pathology
Shanghai Medical College of Fudan University
2009-2024
State Key Laboratory of Medical Neurobiology
2012-2024
Fudan University
2015-2024
Instituto Medicina Integrativa (Portugal)
2021
Chinese Institute for Brain Research
2020
Novem (Netherlands)
2019
The University of Texas MD Anderson Cancer Center
2013-2015
Zero to Three
2015
Committee on Publication Ethics
2015
University of Illinois Urbana-Champaign
2012
Chemotherapy-induced peripheral neuropathy (CIPN) characterized by loss of sensory sensitivity and pain in hands feet is the major dose-limiting toxicity many chemotherapeutics. At present, there are no FDA-approved treatments for CIPN. The anti-diabetic drug metformin most widely used prescription world improves glycemic control diabetes patients. There some evidence that enhances efficacy cancer treatment. aim this study was to test hypothesis protects against chemotherapy-induced...
Abstract Background Chronic pain is often associated with microglia activation in the spinal cord. We recently showed that microglial levels of kinase G protein–coupled receptor (GRK)2 are reduced models chronic pain. also found mice a cell-specific reduction around 50% GRK2 level microglia/macrophages (LysM-GRK2 +/− mice) develop prolonged inflammatory hyperalgesia concomitantly ongoing microglia/macrophage activation. The microRNA miR-124 thought to keep brain and cord quiescent state. In...
Abstract Background Emerging evidence indicates that nerve damage–initiated neuroinflammation and immune responses, which are evidenced by the up-regulation of proinflammatory cytokines, contribute to development neuropathic pain. This study investigated role spinal interleukin (IL)-33 its receptor ST2 in spared injury (SNI)-induced Methods The von Frey test acetone were performed evaluate pain behaviors (n = 8 12), Western blot 4 6), immunohistochemistry, real-time polymerase chain reaction...
Background There is current interest in understanding the molecular mechanisms of tumor-induced bone pain. Accumulated evidence shows that endogenous formaldehyde concentrations are elevated blood or urine patients with breast, prostate bladder cancer. These cancers frequently associated cancer pain especially after metastasis. It well known transient receptor potential vanilloid 1 (TRPV1) participates The present study aims to demonstrate tumor tissue-derived induces via TRPV1 activation...
Abstract Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) cascade NAcht leucine-rich-repeat protein 1 (NALP1) inflammasome are important for synthesis Pro-Interleukin (IL)-1β processing inactive its mature form, which plays an active role pathogenesis neuropathic pain. The present study showed repeated intraperitoneal injection curcumin ameliorated...
Abstract Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of itch induced by poison ivy. However, how IL‐33/ST2 signaling cord potentially mediates remains elusive. Here, we determined St2 −/− substantially reduced scratching behaviors 2,4‐dinitrofluorobenzene (DNFB)‐induced allergic contact dermatitis (ACD) as well acetone diethylether followed water‐induced...
Abstract It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP), which is different from neuropathic inflammatory pain. The present study was designed to investigate the role spinal Toll-like receptor 4 (TLR4) glial neuroinflammation using a modified rat model bone cancer. CIP consisted unilateral intra-tibial injection with Walker 256 mammary gland carcinoma. Nine days after inoculation, robust both bilateral dorsal...
Abstract Background The neuroinflammatory responses in the spinal cord following bone cancer development have been shown to play an important role cancer-induced pain (CIBP). Lipoxins (LXs), endogenous lipoxygenase-derived eicosanoids, represent a unique class of lipid mediators that possess wide spectrum anti-inflammatory and pro-resolving actions. In this study, we investigated effects intrathecal injection with lipoxin related analogues on CIBP rats. Methods model was induced by...
Abstract Trigeminal neuralgia (TN) is debilitating and usually accompanied by mood disorders. The lateral habenula (LHb) considered to be involved in the modulation of pain disorders, present study aimed determine if how LHb participates development anxiety TN. To address this issue, a mouse model partial transection infraorbital nerve (pT-ION) was established. pT-ION induced stable long-lasting primary secondary orofacial allodynia anxiety-like behaviors that correlated with increased...
Cancer pain is a pervasive clinical symptom impairing life quality. Vascular endothelial growth factor A has been well studied in tumor angiogenesis and recognized as therapeutic target for anti-cancer treatment. This study tested the hypothesis that vascular receptor 2 contribute to bone cancer regulation associated with spinal central sensitization.This was performed on female rats using metastatic breast model. Nociceptive behaviors were evaluated by mechanical allodynia, thermal...
Blocking opioid-induced chemokine release from astrocytes may improve long-term pain management.
G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study, we investigated spinal neuronal GRK2 electroacupuncture (EA) analgesia.The mice model inflammatory was built by subcutaneous injection Complete Freund's Adjuvant (CFA) into plantar surface hind paws. The mechanical allodynia examined von Frey test. were subjected EA treatment (BL60 and...
The coexistence of chronic pain and anxiety is a common clinical phenomenon. Here, the role tachykinin receptor 3 (NK3R) in lateral habenula (LHb) trigeminal neuralgia pain-associated was systematically investigated. First, electrophysiological recording showed that bilateral LHb neurons are hyperactive mouse model made by partial transection infraorbital nerve (pT-ION). Chemicogenetic activation glutamatergic naive mice induced orofacial allodynia anxiety-like behaviors, pharmacological...
Abstract Background Orexin A (OXA, hypocretin/hcrt 1) is a newly discovered potential analgesic substance. However, whether OXA involved in acupuncture analgesia remains unknown. The present study was designed to investigate the involvement of spinal electroacupuncture (EA) analgesia. Methods modified rat model post-laparotomy pain adopted and evaluated. Von Frey filaments were used measure mechanical allodynia hind paw abdomen. EA at 2/15 Hz or 2/100 performed once on bilateral ST36 SP6 for...
Cold allodynia is a common complaint of patients suffering from neuropathic pain initiated by peripheral nerve injury. However, the mechanisms that drive cold remain elusive. In this study, we show interleukin (IL)-33/ST2 signaling in dorsal root ganglion (DRG) critical contributor to interacting with sensor transient receptor potential melastatin 8 (TRPM8). By using St2-/- mice, demonstrate ST2 required for generation nociceptor hyperexcitability and mouse model spared injury (SNI)....