A5078953825- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Brain Metastases and Treatment
- Birth, Development, and Health
- Glioma Diagnosis and Treatment
- Galectins and Cancer Biology
- Formal Methods in Verification
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Machine Learning in Materials Science
- Child Nutrition and Feeding Issues
- Parallel Computing and Optimization Techniques
- Software Engineering Research
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Logic, programming, and type systems
- Reproductive System and Pregnancy
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Cancer survivorship and care
UNSW Sydney
2014-2025
Monash University
2015-2024
Neuroscience Research Australia
2018-2024
Peter MacCallum Cancer Centre
2017-2023
Deakin University
2023
AstraZeneca (United Kingdom)
2023
Concord Repatriation General Hospital
2022
The Netherlands Cancer Institute
2022
Austin Health
2022
The University of Sydney
2022
Beta-adrenergic blockade has been associated with improved cancer survival in patients triple-negative breast (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship between beta-blocker use and anthracycline chemotherapy protecting against TNBC progression, disease recurrence, mortality. We recapitulated effect beta-blockade on efficacy xenograft mouse models TNBC. metastatic 4T1.2 MDA-MB-231 TNBC, doxorubicin by...
Chronic stress accelerates metastasis - the main cause of death in cancer patients through activation β-adrenoceptors (βARs). We have previously shown that β2AR signaling MDA-MB-231(HM) breast cells, facilitates invadopodia formation and invasion vitro. However, tumor microenvironment where many stromal cells also express βAR, role is unclear. Therefore, to investigate contribution vivo, we used RNA interference generate are deficient β2AR. knockdown reduced proportion with a...
This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways oncology patients with without self-reported cancer-related cognitive impairment (CRCI). In a sample of receiving chemotherapy (n = 1343), Attentional Function Index (AFI) was used to assess CRCI. Patients were grouped into low (AFI score < 5) versus high > 7.5) levels function. Gene expression analyses done using...
Abstract Elevations in plasma levels of pro-inflammatory cytokines and C-reactive protein (CRP) patient blood have been associated with impairments cognitive abilities more severe psychiatric symptoms people schizophrenia. The transcription factor nuclear kappa B (NF-κB) regulates the gene expression factors whose products trigger CRP release. NF-κB activation pathway mRNAs are increased brain schizophrenia strongly related to neuroinflammation. Thus, it is likely that this central immune...
"Perinatal programming" is a phenomenon describing how early life environmental conditions can produce long-term physiological alterations that either enhance or inhibit adaptive functioning. Previously, we have demonstrated neonatal exposure to lipopolysaccharide (LPS) predisposes anxiety-like behaviour in later life, which was associated with changes the neuroendocrine response stress. Given known interactions between and neuroimmune systems, here investigated whether bacterial mimetic...
Automatic device driver synthesis is a radical approach to creating drivers faster and with fewer defects by generating them automatically based on hardware specifications. We present the design implementation of new toolkit, called Termite-2. Termite-2 first tool combine power automation flexibility conventional development. It also practical abstraction refinement. Finally, it support automated debugging input demonstrate practicality synthesizing for number I/O devices representative...
Cancer patients with non-central nervous system tumors often suffer from cognitive impairment. While chemotherapy has long been attributed as the cause of these memory, learning and concentration difficulties, we recently observed impairment in cancer prior to treatment. This suggests alone may be sufficient induce impairment, however mechanisms are unknown. Here, show that can experimentally replicate clinical phenomenon cancer-associated identify inflammation a causal mechanism. We...
Abstract Background High inflammation status despite an absence of known infection characterizes a subpopulation people with schizophrenia who suffer from more severe cognitive deficits, less cortical grey matter, and worse neuropathology. Transcripts encoding factors upstream nuclear factor kappa B (NF-κB), major transcriptional activator for the synthesis pro-inflammatory cytokines, are increased in frontal cortex compared to controls. However, extent which these changes disease-specific,...
Cancer patients have a highly increased risk of psychiatric disorders following diagnosis, compared with cancer-free individuals. Inflammation is involved in the development both cancer and disorders. The role non-steroidal anti-inflammatory drugs (NSAIDs) subsequent after diagnosis however unknown.We performed cohort study all diagnosed first primary malignancy between July 2006 December 2013 Sweden. Cox proportional hazards models were used to assess association NSAID use during year...
Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these in an animal model looked at their effects, alone combination, on serotonin <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>5HT</mml:mtext><mml:mrow><mml:mtext>1A</mml:mtext></mml:mrow></mml:msub></mml:math> receptor binding (<mml:math...