A5068040716- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related cognitive impairment studies
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Anesthesia and Sedative Agents
- Diabetes Management and Research
- Polysaccharides and Plant Cell Walls
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vagus Nerve Stimulation Research
- Molecular Sensors and Ion Detection
- Renaissance and Early Modern Studies
- Lipid Membrane Structure and Behavior
- Architecture and Art History Studies
- Historical Art and Architecture Studies
Monash University
2013-2023
Discovery Institute
2021
University Medical Center
2009
University of Edinburgh
2002
University of Tübingen
1985
Beta-adrenergic blockade has been associated with improved cancer survival in patients triple-negative breast (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship between beta-blocker use and anthracycline chemotherapy protecting against TNBC progression, disease recurrence, mortality. We recapitulated effect beta-blockade on efficacy xenograft mouse models TNBC. metastatic 4T1.2 MDA-MB-231 TNBC, doxorubicin by...
Cancer patients with non-central nervous system tumors often suffer from cognitive impairment. While chemotherapy has long been attributed as the cause of these memory, learning and concentration difficulties, we recently observed impairment in cancer prior to treatment. This suggests alone may be sufficient induce impairment, however mechanisms are unknown. Here, show that can experimentally replicate clinical phenomenon cancer-associated identify inflammation a causal mechanism. We...
The therapeutic action of a drug depends on its ability to engage with molecular target in vivo. However, current discovery strategies quantify levels within organs rather than determining the binding drugs directly their specific targets This is particular problem for assessing potential that malignant tumors where access and may be impaired by disrupted vasculature local hypoxia. Here we have used triple-negative human breast cancer cells expressing β2-adrenoceptors tagged bioluminescence...
Disruption of circadian rhythms occurs in rotating shift-work, jetlag, and individuals with irregular sleep schedules. Circadian disruption is known to alter inflammatory responses impair immune function. However, there limited understanding how modulates cancer-induced inflammation. Inflammation a hallmark cancer linked worse prognosis impaired brain function patients. Here, we investigated the effect on inflammation an orthotopic breast model. Using validated chronic jetlag protocol that...
Inflammation has been proposed to play a causal role in chemobrain which—if true—would represent an opportunity repurpose existing anti-inflammatory drugs for the prevention and treatment of chemobrain. Here, we show that chemoagent paclitaxel induces memory impairment anhedonia mice within 24 h cessation, but inflammation is not present until 2 weeks after treatment. We find no evidence brain as measured by cytokine analysis at any time point. Furthermore, treating with aspirin block did...
Surgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use propofol-based total intravenous anesthesia during cancer resection surgery associated with improved overall survival compared to inhaled volatile anesthesia. Evaluating these findings in prospective studies required inform definitive guidelines but will take many years and requires biomarkers monitor effect. Therefore, we examined the effect different...
Synthetic bifunctional analogues 4a,b and 14 of dolichol phosphate 1 were attached to solid support shown be substrates for Dol-P-Man synthase.
Anesthesia is a routine component of cancer care that used for diagnostic and therapeutic procedures. The anesthetic technique has recently been implicated in impacting long-term outcomes, possibly through modulation adrenergic-inflammatory responses impact cell behavior immune function. Emerging evidence suggests propofol-based total intravenous anesthesia (TIVA) may be beneficial outcomes when compared to inhaled volatile anesthesia. However, the available clinical findings are...
Anesthesia is a routine component of cancer care that used for diagnostic and therapeutic procedures. The anesthetic technique has recently been implicated in impacting long-term outcomes, possibly through modulation adrenergic-inflammatory responses impact cell behavior immune function. Emerging evidence suggests propofol-based total intravenous anesthesia (TIVA) may be beneficial outcomes when compared to inhaled volatile anesthesia. However, the available clinical findings are...