A5059787887- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Pain Management and Opioid Use
- Tryptophan and brain disorders
- Voice and Speech Disorders
- Resilience and Mental Health
- Musculoskeletal pain and rehabilitation
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Racial and Ethnic Identity Research
- Sleep and related disorders
- Suicide and Self-Harm Studies
- Pain Mechanisms and Treatments
- Meta-analysis and systematic reviews
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Family and Patient Care in Intensive Care Units
- Statistical Methods in Clinical Trials
- Intensive Care Unit Cognitive Disorders
- Dysphagia Assessment and Management
Dana-Farber Cancer Institute
2022-2025
University of California, San Francisco
2007-2024
Wright Institute
2024
Cohen Children's Medical Center
2024
RELX Group (United States)
2023
University of Pittsburgh
2022
New York University
2022
Vestergaard (Switzerland)
2022
University of California, Los Angeles
2019
Stanford University
2007
ABSTRACT Background Detailed information on patient characteristics and symptom burden associated with multimorbidity in oncology patients is extremely limited. Purposes were to determine the prevalence of low (≤ 2) high (≥ 3) a sample outpatients ( n = 1343) undergoing chemotherapy evaluate for differences between two groups demographic clinical characteristics; occurrence, severity, distress 38 symptoms; stability consistency clusters. Methods Using Self‐Administered Comorbidity...
This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways oncology patients with without self-reported cancer-related cognitive impairment (CRCI). In a sample of receiving chemotherapy (n = 1343), Attentional Function Index (AFI) was used to assess CRCI. Patients were grouped into low (AFI score < 5) versus high > 7.5) levels function. Gene expression analyses done using...
Shortness of breath occurs in 10%-70% oncology patients. Very little is known about interindividual variability its severity and distress associated risk factors. Using latent profile analyses (LPAs), purpose was to identify subgroups patients with distinct profiles for shortness as single symptom dimensions. In addition, a joint LPA done using patients' AND ratings. For each the three LPAs, differences among classes demographic, clinical, symptom, stress, resilience characteristics were evaluated.
Anxiety and depression are common symptoms in oncology patients undergoing chemotherapy. Study purpose was to evaluate for differences severity of (ie, fatigue, energy, sleep disturbance, cognitive function, pain) quality life (QOL) outcomes among three subgroups outpatients with distinct joint anxiety profiles. Oncology (N = 1328) completed measures state depression, six times over two cycles Latent profile analysis done identify AND Patients trait anxiety, morning evening pain, as well...
Significance: Evening fatigue and depressive symptoms are associated with several negative outcomes for patients cancer. However, the contribution of BOTH to patient remains unknown. This study identified subgroups distinct joint evening AND symptom profiles evaluated differences in demographic clinical characteristics, levels stress (i.e., global, cancer‐specific, cumulative life) resilience, severity common symptoms. Methods: Outpatients ( n = 1334) completed Lee Fatigue Scale Center...
Abstract Background By 2035, the number of newly diagnosed cancer cases will double and over 50% be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients’ symptom burden. The study purposes were evaluate for differences occurrence, severity, distress 38 symptoms younger (< 60 years) versus (≥ patients undergoing chemotherapy stability consistency clusters across two groups. Methods A total 1329 dichotomized into Patients...
Background Depression is a pervasive symptom in patients with gynecological cancer undergoing chemotherapy. Objectives Purposes were to identify subgroups of distinct depression profiles and evaluate for differences demographic clinical characteristics, severity common symptoms, quality life (QOL) outcomes among these subgroups. Methods Patients (n = 231) completed the Center Epidemiologic Studies–Depression Scale 6 times over 2 cycles All other measures prior second or third cycle Latent...
Abstract Background Moderate to severe fatigue occurs in up 94% of patients with cancer. Recent evidence suggests that morning and evening are distinct dimensions physical fatigue. The purposes this study were evaluate the transcriptome for common perturbed inflammatory pathways receiving chemotherapy who reported low versus high levels or cancer‐related Methods Patients completed questionnaires during week prior their treatment. Severity was evaluated using Lee Fatigue Scale. Gene...
Decrements in energy were found 67% of women who underwent breast cancer surgery. However, no information is available on chronic decrements and associations with inflammation. Purposes to identify latent classes patients distinct average profiles from prior through 12 months after surgery; evaluate for differences demographic clinical characteristics between the two extreme classes; polymorphisms cytokine genes associated membership Low class.
While pain is a significant problem for oncology patients, little known about interindividual variability in characteristics.
Cancer-related cognitive impairment (CRCI) is reported by 57% of patients with breast cancer (Schmidt et al., 2016). CRCI can include difficulties attention and concentration, decrements in motivation, an inability to recall names familiar objects or people, memory loss (Mayo 2021). The molecular mechanisms that underlie are complex not fully understood (Oppegaard 2022). Therefore, progress the development prevention mitigation strategies remains limited (Onzi
To evaluate for differences in global, cancer-specific, and cumulative life stress, as well resilience use of various coping strategies among five groups (no depression or sleep disturbance, no moderate subsyndromal very high disturbance [Both Moderate]; High]).
Background Anxiety and sleep disturbance are frequent symptoms during chemotherapy. Objectives Purposes were to identify subgroups of oncology outpatients with distinct joint anxiety profiles, as well evaluate for differences in demographic clinical characteristics, severity common symptoms, quality-of-life outcomes among these subgroups. Methods Oncology (n = 1331) completed self-report measures 6 times over 2 chemotherapy cycles. Latent profile analysis was done patients profiles. Results...
Dyspnea is a common and distressing symptom that occurs in about 58% of patients with cancer (Shin et al., 2023). Despite its associated burden, dyspnea underestimated clinical practice (Iyer 2014). The American Thoracic Society defined as “a subjective experience breathing discomfort consists qualitatively distinct sensations vary intensity” (Parshall 2012, p. 436).