A5101810882- Immune cells in cancer
- Immune Response and Inflammation
- Web and Library Services
- Electric Vehicles and Infrastructure
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Library Science and Information Literacy
- interferon and immune responses
- Advanced Battery Technologies Research
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Asian Culture and Media Studies
- Higher Education and Teaching Methods
- Educational Reforms and Innovations
- Inflammasome and immune disorders
- Aquaculture disease management and microbiota
- Psoriasis: Treatment and Pathogenesis
- Air Quality and Health Impacts
- Transportation and Mobility Innovations
- Media, Gender, and Advertising
- Library Collection Development and Digital Resources
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
Second Affiliated Hospital of Zhejiang University
2018-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Tsinghua Sichuan Energy Internet Research Institute
2023-2025
Tsinghua University
2023-2025
Harbin Institute of Technology
2025
Anhui Normal University
2025
Shinawatra University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Suzhou Institute of Systems Medicine
2024
Abstract STING (stimulator of interferon genes) has recently been found to play an important role in host defenses against virus and intracellular bacteria via the regulation type-I IFN signaling innate immunity. Chronic infection with Helicobacter pylori is identified as strongest risk factor for gastric cancer. Thus, we aim explore function development Immunohistochemistry was used detect expression 217 cancer patients who underwent surgical resection. protein remarkably decreased tumor...
Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote neoplastic growth by inhibiting the tumoricidal activity T cells. However, direct interactions between patient-derived MDSCs and circulating tumors (CTCs) within microenvironment blood remain unexplored. Dissecting interplays CTCs circulatory heterotypic CTC/MDSC clustering critical as a key mechanism CTC survival sustain metastatic process. We characterized polymorphonuclear-MDSCs (PMN-MDSCs) isolated...
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse of neutrophils formation. Our study focuses on existence biological function rarely delved subset neutrophils, named as tumor-associated aged (Naged, CXCR4 + CD62L low ), involved formation during breast cancer metastasis. Methods We explored distributions Naged 206 patients mice models (4T1 MMTV-PyMT) by flow cytometry. The ability to form...
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in paucity effective therapeutic strategies. Herein, we have developed polydopamine-coated zinc-copper bimetallic nanoplatforms (Cu-ZnO2@PDA nanoplatforms, abbreviated CZP NPs) that can efficiently induce photothermal amplified cuproptosis cGAS-STING signaling pathway activation, thereby reversing the immunosuppressive tumor...
Abstract Triple-negative breast cancer (TNBC) is highly aggressive, difficult to treat and commonly develops visceral metastasis, including lung metastasis. We observed that High mobility group box 1 protein (HMGB1) was expressed in human TNBC positively correlated with The hypoxic tumor environment known regulate HMGB1 secretion, but an understanding of the underlying mechanism by which tumor-derived regulates interstitial components promotes metastasis has remained elusive. results present...
The health behaviors and blood pressure control of patients with hypertension who have had a stroke are unsatisfactory. A protocol comprehensive reminder system has been published, the results 3 months implementation demonstrated improved patient control. continuity intervention effect on these variables after was not clear.The aim this study to determine impact behaviors, medication adherence, pressure, disability, recurrence in from baseline 6 discharge.A multicenter, assessor-blinded,...
Dysbiosis of gut microbiota might promote the pathophysiological process aCSVD.
Health, as basic human capital, is quite important for rural adults. However, in China, the average level of public health facilities and services far lower areas than cities. In recent years, internet has developed rapidly increasingly affecting adults a positive way. The purpose this paper to reveal whether use can be an effective way improve This study used three rounds data from China Family Panel Studies (CFPS) collected 2014, 2016, 2018. After eliminating samples due attrition,...
Abstract Background Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) strongly linked to a poor prognosis among patients with cancer, emphasizing critical role neutrophils. Although involvement neutrophils in tumor metastasis well documented, their interactions primary tumors cells are not yet fully understood. Methods Clinical data were analyzed investigate In...
Grid capacity constraints present a prominent challenge in the construction of ultra-fast charging (UFC) stations. Active load management (ALM) and battery energy storage systems (BESSs) are currently two primary countermeasures to address this issue. ALM allows UFC stations install larger-capacity transformers by utilizing valley margins meet peak demand during grid periods, while BESSs rely more on batteries solve gap between transformer This paper proposes four-quadrant classification...
Interleukin-33 (IL-33) is a novel identified chromatin-associated cytokine of IL-1 family cytokines. It signals through heterodimer comprised IL‑1 receptor-related protein ST2 and receptor accessory (IL-1RAcP), plays crucial role in many diseases. However, very little known about the underlying intricate mechanisms IL-33 recurrent neonatal seizure (RNS). To determine whether an important regulatory role, we established model this study. Rats were subjected to seizures induced by inhaling...
Breast cancer is the most common malignant tumor in women, and lung metastasis one of leading causes death breast patients. The mechanism still controversial at present. Recently, formation pre-metastatic niche considered to be a key factor for metastasis, which could also explain tendency organ metastasis. Our study firstly re-explored critical time formation, simultaneously found group CD62Ldim neutrophils subsets that were not reported previously tumor, progressively increased during...
Amyotrophic lateral sclerosis (ALS) is a progressively worsening neurodegenerative condition with very few treatment options available. Ultrasound neuromodulation offers promising benefits for treating diseases such as Parkinson's and Alzheimer's diseases. However, the effects underlying mechanisms of ultrasound on ALS remain unclear. A head-mounted system was developed to noninvasively stimulate motor cortex symptomatic mice carrying G93A human SOD1 mutation (<italic...
Residential electric vehicle (EV) chargers in China are typically paired with independent smart meters. A bi-level method for extracting flexibility features and clustering residential EV users is proposed based on real-world meter data, offering significant advantages terms of data accessibility implementation feasibility. First, from over 5000 partitioned into charging segments, which then filtered grouped. At the segment level, three extracted using Pearson correlation method, six...
This study investigates the current challenges in teaching ancient Chinese poetry and art songs higher education. We collected data using a mixed-methods approach from 299 students, 27 teachers, 3 experts across nine music conservatories China. Results reveal widespread difficulties among students mastering vocal techniques interpreting poetic content, while instructors report fragmented curricula, outdated materials, limited professional training. Expert interviews highlight lack of...
Abstract Small interfering RNAs (siRNAs) represent a novel tool to induce gene silencing in mammalian cells and clinical trials are currently ongoing assess the therapeutic efficacy of siRNAs various human diseases, including age-related macular degeneration respiratory syncytial virus infection. However, previously reported off-target, nonspecific effects siRNAs, activation type I IFNs proinflammatory cytokines, remain an outstanding concern regarding use these agents vivo....