A5102858886- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Imaging and Diagnostics
- Potassium and Related Disorders
- Heart rate and cardiovascular health
- Membrane-based Ion Separation Techniques
- Intensive Care Unit Cognitive Disorders
- Cardiac Fibrosis and Remodeling
- Cardiovascular Disease and Adiposity
- Electrochemical Analysis and Applications
- Cardiomyopathy and Myosin Studies
- Medicinal Plants and Neuroprotection
- Cardiovascular Health and Disease Prevention
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Artery Anomalies
- IL-33, ST2, and ILC Pathways
- Healthcare Systems and Practices
- Cardiovascular Health and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammation biomarkers and pathways
- Medicinal Plants and Bioactive Compounds
- Protein Tyrosine Phosphatases
Fudan University
2014-2025
Zhongshan Hospital
2014-2025
Anhui University
2024-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Sun Yat-sen University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Zhongshan Hospital of Xiamen University
2023-2024
<h3>Background:</h3> The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine reduced serum concentrations in obese subjects. A study was undertaken to examine whether the adiponectin concentration is associated human and it explains between asthma, particularly women premenopausal women. <h3>Methods:</h3> cross-sectional analysis performed 2890 eligible subjects at year 15 Coronary Artery Risk Development Young Adults (CARDIA) cohort its...
Abstract Aims This study aims to investigate hospital readmissions and timing, as well risk factors in a real world heart failure (HF) population. Methods results All patients discharged alive 2016 from Sahlgrenska University Hospital/Östra, Gothenburg, Sweden, with primary diagnosis of HF were consecutively included. Patient characteristics, type HF, treatment, follow‐up registered. Time first all‐cause or readmission, number 1 year discharge recorded. In total, 448 included: 273 (mean age...
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis very complex and far from defined. Here, we explored the N 6 -methyladenosine (m6A) RNA methylation alteration patients HFpEF mouse model of HFpEF. Methods: In this case–control study, peripheral blood mononuclear cells (PBMCs) were separated samples obtained 16 24 healthy controls. The change m6A regulators was detected by quantitative real-time PCR (RT-PCR). A “two-hit”...
: Heart failure with preserved ejection fraction (HFpEF) is a predominant type of heart failure. Exploring new pathogenesis and identifying potential novel therapeutic targets for HFpEF paramount importance.
In this study, we conducted an in-depth exploration of Alzheimer's Disease (AD) by integrating state-of-the-art methodologies, including single-cell RNA sequencing (scRNA-seq), weighted gene co-expression network analysis (WGCNA), and a convolutional neural (CNN) model. Focusing on the pivotal role microglia in AD pathology, our revealed 11 distinct microglial subclusters, with 4 exhibiting obviously alterations HC groups. The investigation cell–cell communication networks unveiled intricate...
Reserpine is used as a cheap and effective first-line antihypertensive, presently, it applied treatment for difficult-to-control cases of hypertension. Despite its significance, reserpine’s neuroendocrine toxicity remains largely underexplored. Here, we investigated the effects reserpine on development, locomotion, central nervous system (CNS) neurons, thyroid expression genes related to neurodevelopment, endocrine, learning memory, depression in zebrafish exposed different doses ranging...
Background Small intestinal bacterial overgrowth (SIBO) is a common pathological condition of microbiota. The prevalence SIBO and its prognostic value in patients with heart failure (HF) are unknown. Methods Results A total 287 tested for using lactulose hydrogen-methane breath test were evaluated. At least 1 the following criteria fulfilled was positive: fasting hydrogen level ≥20 parts per million (ppm) or ppm rise by 90 minutes diagnosed (H2) positive; methane levels ≥10 at any point...
Abstract Aims The aim of this study was to investigate whether the readmission heart failure (HF) patients has decreased over time and how it differs among HF with preserved ejection fraction (EF) (HFpEF) vs. reduced EF (HFrEF) mid‐range (HFmrEF). Methods results We evaluated index hospitalized from January 2004 December 2011 in Swedish Heart Failure Registry 1 year follow‐up. Outcome measures were first occurring all‐cause, cardiovascular (CV), readmissions. A total 20 877 (11 064 HFrEF,...
Background Relationship of left ventricular diastolic dysfunction (LVDD) with parameters that could provide more information than hemodynamic renal indexes has not been clarified. We aimed to explore the association comprehensive LVDD in a community-based elderly population. Methods 1,166 community residents (aged ≥ 65 years, 694 females) participating Shanghai Heart Health Study complete data were investigated. Echocardiography was used evaluate function conventional and tissue Doppler...
Background and Objective: Angiogenesis is the most important repair process of tissues subjected to ischemic injury. The present study aims investigate whether pro-angiogenic effect Qiliqiangxin prescription (QL) mediated through miR-21 signaling. Methods: Cardiac microvascular endothelial cells (CMECs) were isolated cultured from 2-3 weeks old SD rats by method planting myocardium tissues. purity was identified CD31 immunofluorescence staining. CMECs then under 1% O2 hypoxia or normoxia...
Abstract Aims The benefits of lowering heart rate (HR) in failure (HF) with preserved ejection fraction (HFpEF) patients are still a matter debate. This study aimed to investigate the relationship between changes HR during hospitalization and cardiovascular (CV) events all‐cause death hospitalized HFpEF patients. Methods results Hospitalized HF January 2017 December 2021 were consecutively enrolled national, multicentred, prospective registry database, China Cardiovascular Association...
Abstract Diastolic dysfunction is common in various cardiovascular diseases, which could be affected by adiponectin (APN). Nevertheless, the effects of APN on diastolic pressure overload model induced transverse aorta constriction (TAC) remain to further elucidated. Here, we demonstrated that treatment attenuated and cardiac hypertrophy TAC mice. Notably, also improved active relaxation adult cardiomyocytes, increased N2BA/N2B ratios titin isoform, reduced collagen type I III ratio lysyl...