A5100335539- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Porphyrin and Phthalocyanine Chemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Aquaculture disease management and microbiota
- Spectroscopy Techniques in Biomedical and Chemical Research
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Legionella and Acanthamoeba research
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- interferon and immune responses
- Cancer Cells and Metastasis
- Aquaculture Nutrition and Growth
Hainan Medical University
2024-2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
State Key Laboratory of Genetic Engineering
2023-2024
Fudan University Shanghai Cancer Center
2024
Center for High Pressure Science & Technology Advanced Research
2024
Southern Medical University
2024
First Hospital of China Medical University
2024
Zhujiang Hospital
2024
Fudan University
2023-2024
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
Endothelin-1 is implicated in the pathogenesis of hypertension, but underlying mechanisms remained elusive. Our previous study found that inhibition mitochondrial fission smooth muscle cells suppressed phenylephrine- and high K+-induced artery constriction. Here, we studied effects inhibitors on endothelin-1-induced vasoconstriction.The tension rat mesenteric arteries thoracic aorta was measured by using a multi-wire myograph system. Mitochondrial morphology aortic observed transmission...
The receptors of Notch family play an important role in controlling the development, differentiation, and function multiple cell types. aim this study is to investigate Notch1 signaling upon immune suppression induced by melanoma cells.Melanoma line B16 cells were transfected lentivirus containing mouse gene or shRNA generate that highly lowly expressed Notch1. anti-tumor response was comprehensively appraised murine tumor model immunocompetent immunodeficient mice. ratios CD3+CD8+ cytotoxic...
Anemia commonly aggravates the severity of respiratory diseases, whereas thus far, few studies have elucidated impact anemia on coronavirus disease 2019 (COVID-19). The aim this study was to evaluate clinical characteristics patients with anemia, and further explore relationship between COVID-19. In single-center, retrospective, observational study, a total 222 confirmed admitted Wuhan Ninth Hospital from 1 December 20 March 2020 were recruited, including 79 143 without anemia. Clinical...
Abstract All of life encodes information with DNA. While tools for sequencing, synthesis, and editing genomic code have transformed biological research, intelligently composing new systems would also require a deep understanding the immense complexity encoded by genomes. We introduce Evo 2, foundation model trained on 9.3 trillion DNA base pairs from highly curated atlas spanning all domains life. train 2 7B 40B parameters to an unprecedented 1 million token context window single-nucleotide...
Cancer progression is associated with alterations of intra- and extramedullary hematopoiesis to support a systemic tumor-promoting myeloid response. However, the functional specialty, mechanism, clinical relevance (EMH) remain unclear. Here, we showed that heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by accumulation precursors, but also profound early hematopoietic stem/progenitor cells (HSPCs). With distinct capability produce respond...
ABSTRACT Clostridium difficile can infect the large intestine and cause colitis when normal intestinal microbiota is altered by antibiotic administration. Little known about innate immune signaling pathways that marshal inflammatory responses to C. infection whether protective pathogenic be dissociated. Toll-like receptors predominantly signal via MyD88 adaptor protein are important mediators of in mucosa. Here, we demonstrate MyD88-mediated signals trigger neutrophil CCR2-dependent Ly6C hi...
Clostridium difficile is a spore-forming bacterium that infects the lower intestinal tract of humans and most common known cause diarrhea among hospitalized patients. colitis mediated by toxins develops during or following antibiotic administration. We have used murine model C. infection, which reproduces major features human disease, to study effect innate immune activation on resistance infection. found administration purified Salmonella-derived flagellin, Toll-like receptor 5 (TLR5)...
Tree peony (Paeonia ostii) is an economically important ornamental plant native to China. It also notable for its seed oil, which abundant in unsaturated fatty acids such as α-linolenic acid (ALA). Here, we report chromosome-level genome assembly (12.28 Gb) of P. ostii. In contrast monocots with giant genomes, tree does not appear have undergone lineage-specific whole-genome duplication. Instead, explosive LTR expansion the intergenic regions within a short period (~ two million years) may...
The high incidence of recurrence and metastasis hepatocellular carcinoma (HCC) necessitate the discovery new predictive biomarkers invasion prognosis. Minichromosome maintenance complex component 6 (MCM6), which has been reported to up-regulate in multiple malignancies, was considered be a novel diagnoses biomarker HCC. However, its functional contributions prognostic value remain unclear.The expression MCM6 analyzed 70 HCC tissues 5 cell lines by immunohistochemistry real-time RT-PCR. roles...
BACKGROUNDDespite an increasing appreciation of the roles that myeloid cells play in tumor progression and therapy, challenges remain interpreting tumor-associated response balance its translational value. We aimed to construct a simple reliable signature for hepatocellular carcinoma (HCC).METHODSUsing situ immunohistochemistry, we assessed distribution major subtypes both peri- intratumoral regions HCC. A 2-feature-based, myeloid-specific prognostic signature, named score (MRS), was...
Recent studies have demonstrated that splenic extramedullary hematopoiesis (EMH) is an important mechanism for the accumulation of myeloid-derived suppressor cells (MDSCs) in tumor tissues, and thus contributes to disease progression. Icaritin, a prenylflavonoid derivative from plants Epimedium genus, has been implicated as novel immune-modulator could prolong survival hepatocellular carcinoma (HCC) patients. However, it unclear whether icaritin achieves its anti-tumor effects via regulation...
A 56-day feeding trial was conducted to investigate the effects of genistein on growth, lipid metabolism, antioxidant capacity, and immunity common carp fed with high-carbohydrate or high-fat diets. Five diets were used feed fish: control diet (5% fat; CO), (11% HF), (45% carbohydrate; HC), HF HC 500 mg/kg (FG CG). Results showed that final body weight (FW) specific growth rate (SGR) significantly reduced, but supplementation resulted in higher values FW SGR than group. Both high...
To examine if BODIPY-electron acceptor conjugates can generate excited triplet state and singlet oxygen efficiently via a photoinduced charge separation–charge recombination (CS-CR) mechanism, seven compounds of (A) type are synthesized, in which an x-nitro-phenyl (x = ortho, meta, para) or pyridyl subunit on the BODIPY meso-position acts as acceptor. The photophysical properties formation efficiency measured solvents different polarity. decrease with increase electron withdrawing ability...
Abstract Propofol is one of the most extensively used intravenous anaesthetic agents, which has been found to improve surgical intervention outcome several types cancer, including hepatocellular carcinoma (HCC). Additionally, in vitro and vivo experiments have also indicated that propofol affects biological behaviour HCC. However, underlying mechanisms resection HCC with not fully understood. In present study, we aimed investigate mechanism inhibition growth invasion cells. Our results...
Microbial synthesis of chemicals typically requires the redistribution metabolic flux toward targeted products. Dynamic control is emerging as an effective approach for solving hurdles mentioned above. As light could cell behavior in a spatial and temporal manner, optogenetic-CRISPR interference (opto-CRISPRi) technique that allocates resources according to different optical signal frequencies will enable bacteria be controlled between growth phase production stage. In this study, we applied...
Abstract Hepatocellular carcinoma (HCC) with lung metastasis is associated poor prognosis and therapeutic outcomes. Studies have demonstrated that stiffened stroma can promote in various tumors. However, how the mechanical microenvironment favors circulating tumor cells remains unclear metastatic HCC. Here, we found expression of cell migration-inducing hyaluronan-binding protein (CEMIP) was closely pre-metastatic niche formation by increasing matrix stiffness. Furthermore, upregulated serum...
Thermal ablation is a crucial therapeutic modality for hepatocellular carcinoma (HCC), but its efficacy often hindered by the high recurrence rate attributed to insufficient ablation. Furthermore, residual tumors following exhibit more pronounced immunosuppressive state, which accelerates disease progression and leads immune checkpoint blockade (ICB) resistance. Herein, evidence presented that heightened intratumoral lactate accumulation, stemming from augmented glycolytic activity of...
Abstract Hypertrophic scar development is a complication associated with wound healing, impacting local appearance and function. The type I/III collagen ratio affects the extent of hypertrophic scarring; reduced can ameliorate this. In this study, recombinant human III was developed. Liquid chromatography–tandem mass spectrometry used to determine its amino acid sequence confirm high level homology natural collagen. Recombinant displayed no cytotoxicity did not confer skin irritation...
Legionella pneumophila enhC - mutants were originally identified as being defective for uptake into host cells. In this work, we found that the absence of EnhC resulted in intracellular growth when dissemination bacteria to neighbouring cells was expected occur. No such defect observed during within amoeba Dictyostelium discoideum. Culture supernatants containing secreted products infected macrophages added restricted ΔenhC strain, while tumour necrosis factor α (TNF-α), at concentrations...