A5100359138- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Remote Sensing and Land Use
- vaccines and immunoinformatics approaches
- Cancer, Hypoxia, and Metabolism
- Environmental Changes in China
- Liver Disease Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Nanoplatforms for cancer theranostics
- Parasite Biology and Host Interactions
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- ATP Synthase and ATPases Research
- Hepatitis C virus research
- Remote Sensing in Agriculture
- Research on Leishmaniasis Studies
- Silymarin and Mushroom Poisoning
- Genomics, phytochemicals, and oxidative stress
- Nanoparticle-Based Drug Delivery
- RNA regulation and disease
Fudan University
2025
South China Normal University
2024-2025
Second Hospital of Shandong University
2025
Second Affiliated Hospital of Guangzhou Medical University
2021-2024
Guangzhou Medical University
2021-2024
Fujian Agriculture and Forestry University
2024
Shandong University
2022
Purdue University West Lafayette
2018
Nanjing Medical University
2016
University of Virginia
1993-2015
To investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus PD-1 inhibitor (TACE-L-P) versus TACE (TACE-L) for patients advanced hepatocellular carcinoma (HCC).Data HCC treated TACE-L-P (TACE-L-P group) or TACE-L (TACE-L from January 2019 to December 2020 were prospectively collected retrospectively analyzed. The differences in overall survival (OS), progression-free (PFS), tumor responses (based on modified Response Evaluation Criteria...
Abstract Background & Aims Our retrospective study has suggested encouraging outcomes of lenvatinib combined with PD‐1 inhibitor and transarterial chemoembolization (TACE) on advanced hepatocellular carcinoma (HCC). This phase II trial was conducted to prospectively investigate the efficacy safety lenvatinib, sintilimab (a inhibitor) plus TACE (Len‐Sin‐TACE) in patients stage HCC. Methods a single‐arm trial. Patients BCLC C HCC were recruited. They received (bodyweight ≥60 kg, 12 mg;...
Thermal ablation is a crucial therapeutic modality for hepatocellular carcinoma (HCC), but its efficacy often hindered by the high recurrence rate attributed to insufficient ablation. Furthermore, residual tumors following exhibit more pronounced immunosuppressive state, which accelerates disease progression and leads immune checkpoint blockade (ICB) resistance. Herein, evidence presented that heightened intratumoral lactate accumulation, stemming from augmented glycolytic activity of...
Previous results from this laboratory demonstrated that the dominant influenza A epitope recognized by HLA-A2.1-restricted cytotoxic T lymphocytes (CTL) HLA-A2.1 transgenic mice was matrix protein 1 (M1) peptide is immunodominant in human CTL responses. However, analysis of a large number lines revealed subset A/PR/8/34-specific murine an distinct M1. Using recombinant vaccinia viruses encoding different gene segments, these shown to be derived A/PR/8 non-structural (NS1). Because did not...
Mangroves, as the most prolific but vulnerable ecosystems, necessitate continuous monitoring for effective conservation. However, mangrove mapping is challenging due to extensive land use changes and highly intertidal dynamics. In this study, a novel index, named Composite Mangrove Index (CMI), was developed map assess growth trends of mangroves, based on truth that spectral-temporal features wetland environment related greenness, moisture, bare soil. To facilitate long-term Continuous...
The response rate of immunotherapy via immune checkpoint blockade in hepatocellular carcinoma (HCC) is limited due to multiple evasion mechanisms. OX40 a T cell co-stimulating molecule which suppresses the cancer by activating effector cells (Teffs) and counteracting regulatory (Tregs). TLR9 belongs toll-like receptor superfamily promotes tumour antigen presentation stimulating maturation dendritic cells. Though combination agonist (CpG) (anti-OX40 antibody) has shown encouraging efficacy...
It is now understood that HBV can induce innate and adaptive immune response disorders by affecting immunosuppressive macrophages, resulting in chronic infection. However, the underlying mechanism not fully understood. Dysregulated protein acetylation reportedly influence differentiation functions of cells coordinating metabolic signaling. This study aims to assess whether suppresses macrophage-mediated responses elucidate mechanisms escape.
Abstract Purpose To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE). Methods Data TACE-refractory HCC who received (sorafenib or lenvatinib) TKI-I from September 2018 December 2020 were retrospectively analyzed. A propensity score matching (PSM) was performed diminish potential bias. The primary endpoints...
Tetraspanins (TSPs) are proteins found on the surface of helminth parasites genus Schistosoma and regarded as potentially protective antigens. The large extracellular loop mansoni tetraspanin-2, Sm-TSP-2, when fused to a thioredoxin partner formulated with Freund's adjuvants, has been shown be an efficacious vaccine against murine schistosomiasis. It is well recognized that CD4(+) T-cell-dependent immunity might play important role schistosomes; however, contribution CD8(+) T cells...
We present an automated pipeline capable of distinguishing the phenotypes myeloid-derived suppressor cells (MDSC) in healthy and tumor-bearing tissues mice using flow cytometry data. In contrast to earlier work where samples are analyzed individually, we analyze all from each tissue collectively a representative template for it. demonstrate with 43 collected three tissues, naive bone-marrow, spleens mice, intra-peritoneal tumor, that set templates serves as better classifier than popular...
Hepatocellular Carcinoma (HCC) features a complex pathophysiology and unpredictable immunosuppressive microenvironment, which limit the effectiveness of traditional therapies lead to poor patient outcomes. Understanding immune characteristics HCC is essential for elucidating microenvironment developing more effective treatments. This study investigates role Peptidyl-prolyl isomerase H (PPIH) in by analyzing its expression, prognosis, methylation levels, relationship with cell infiltration....
Abstract The increasingly warm-wetting climate has gradually promoted vegetation greenness on the Tibetan Plateau and surrounding region, yet specific mechanisms driving this change in high-altitude mountainous areas remain unclear. This study, using Nepal as a case investigated spatial temporal impacts of hydro-climatic factors Leaf Area Index (LAI) Gross Primary Productivity (GPP), well coupling degree GPP-LAI expressed correlation coefficient (R²) these trends from 2003 to 2020. results...