A5102965761- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- 3D Printing in Biomedical Research
- Hepatitis C virus research
- Retinal Diseases and Treatments
- Ginseng Biological Effects and Applications
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Cancer Cells and Metastasis
- Retinal and Macular Surgery
- MicroRNA in disease regulation
- Intraocular Surgery and Lenses
- COVID-19 Impact on Reproduction
- RNA regulation and disease
- Photodynamic Therapy Research Studies
- Hops Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Powdery Mildew Fungal Diseases
- Ophthalmology and Visual Impairment Studies
- Advanced Biosensing Techniques and Applications
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Liver physiology and pathology
- Nanoplatforms for cancer theranostics
China Medical University
2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Zhongshan Hospital
2021-2024
Fudan University
2021-2024
Sun Yat-sen University
2021-2024
Shanghai Institute of Hematology
2021-2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2024
Xiamen University
2024
Shanghai Tenth People's Hospital
2021-2022
Background and Aims: Liver fibrosis is a leading indicator for increased mortality long-term comorbidity in NASH. Activation of HSCs excessive extracellular matrix production are the hallmarks liver fibrogenesis. Tyrosine kinase receptor (TrkB) multifunctional that participates neurodegenerative disorders. However, paucity literature available about TrkB function fibrosis. Herein, regulatory network therapeutic potential were explored progression hepatic Methods Results: The protein level...
Abstract Background Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced TGF-β families. Migrasome recently discovered type extracellular vesicle related to cell migration. Results Here, we used ex vivo, in vitro, and vivo models, investigate characteristics functions migrasomes RPE PVR development. indicated that migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed human...
Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate tissues, they lack cellular intricacy, and integrating these high-throughput screening remains a challenge. Here, we introduce method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, create spheroids customizable layout. To demonstrate its uniqueness, our effectively creates designer by combining...
Pancreatic cancer is a common malignant tumor with high incidence and mortality rate. The prognosis of patients pancreatic considerably poor due to the lack effective treatment in clinically. Despite numerous studies have revealed that baicalein, natural product, responsible for suppressing multiple cells proliferation, motility invasion. mechanism by which baicalein restraining progression remains unclear. In this study, we firstly verified plays critical role inhibiting tumorigenesis vitro...
Hepatocellular carcinoma (HCC) as a main type of primary liver cancers has become one the most deadly tumors because its high morbidity and poor prognosis. Fucoidan is family natural, heparin-like sulfated polysaccharides extracted from brown algae. It not only widely used dietary supplement, but also participates in many biological activities, such anti-oxidation, anti-inflammation anti-tumor. However, mechanism fucoidan induced inhibition HCC elusive. In our study, we demonstrated that...
ABSTRACT Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use two antivirals together much more efficacious. In vitro drug-drug combination analysis utilizing related members family Flaviviridae , bovine viral diarrhea and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.
To report the long-term results of scleral buckling using 25-gauge chandelier illumination.The medical records all patients presenting to Shanghai Tenth People's Hospital with simple rhegmatogenous retinal detachment (RRD) from June 2013 Oct 2015 were retrospectively reviewed in this consecutive case series. All underwent preoperative and postoperative best corrected visual acuity (BCVA), B-ultrasound, fundus photography, optical coherence tomography examination. Ultrasound biomicroscopy...
Abstract Studies have reported variable effects of sex hormones on serious diseases. Severe disease and mortality rates in COVID‐19 show marked gender differences that may be related to hormones. Sex regulate the expression viral receptors ACE2 TMPRSS2, which affect extent infection consequently cause outcomes. In addition, complex regulatory mechanisms immune response viruses. These also metabolism, leading visceral obesity severe can result from complications such as thrombosis. This...
Research efforts on the human immunodeficiency virus (HIV) integrase have resulted in two approved drugs. However, co-infection of HIV with Mycobacterium tuberculosis and other microbial viral agents has introduced added complications to this pandemic, requiring favorable drug-drug interaction profiles for antiviral therapeutics targeting HIV. Cytochrome P450 (CYP) uridine 5'-diphospho-glucuronosyltransferase (UGT) are pivotal determining factors occurrence adverse interactions. For reason,...
Abstract In vitro models are crucial for drug screening, yet they often fail to accurately reflect human physiological responses. While 3D cell cultures aim simulate tissues, many lack the detailed complexity and interaction of various types found in actual tissues. Additionally, integrating these with high-throughput screening remains a challenge. Current can't strike balance between capturing diseases being suitable large-scale tests. Here we introduce method that uses self-assembling...
Abstract Background： Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced TGF-β families. Migrasomes recently discovered type extracellular vesicles related to cell migration. Results: Here, we used ex vivo, in vitro , and vivo models, investigate characteristics functions migrasomes RPE PVR development. Results indicated that migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed human...