A5001322335- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry
National Taiwan University
2025
Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate tissues, they lack cellular intricacy, and integrating these high-throughput screening remains a challenge. Here, we introduce method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, create spheroids customizable layout. To demonstrate its uniqueness, our effectively creates designer by combining...
Synthetic nucleic acid-based computing has demonstrated complex computational capabilities in vitro. However, translating these circuits into living cells remains challenging because of instability and cellular interference. We introduce an allosteric strand exchange (ASE) strategy for intracellular computing. Leveraging conformational cooperativity to regulate exchange, ASE offers a modular platform designing with flexible programmability. engineer scalable circuit architecture based on...
Abstract Detecting volatile organic compounds (VOCs) is essential for human health and environmental safety. In this study, luminescent lanthanide‐based nanocomposite hydrogels featuring injectable self‐healing properties are developed VOC sensing. Europium‐containing laponite (Eu 3+ @Lap) 2‐thiophenyltrifluoroacetone (TTA)‐modified Eu @Lap (TTA)@Lap) incorporated into a dynamic cross‐linked hydrogel network composed of polyethyleneimine‐modified gelatin polydextran aldehyde (PG/PDA),...
Chimeric antigen receptor (CAR) T-cell therapies have shown remarkable results in patients with hematological malignancies. However, their success treating solid tumors has been limited. As an alternative candidate for the CAR therapy, CAR-macrophages (CAR-M) demonstrated activation and phagocytosis directed by tumor-associated (TAA), showing promise treatment of tumors. Nevertheless, mechanisms which CARs direct tumor chemotaxis invasion CAR-M remain poorly understood. In this study, we aim...