A5100652100- Muscle Physiology and Disorders
- Cleft Lip and Palate Research
- Tissue Engineering and Regenerative Medicine
- Microfluidic and Bio-sensing Technologies
- Cancer-related molecular mechanisms research
- Microfluidic and Capillary Electrophoresis Applications
- Fetal and Pediatric Neurological Disorders
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Prenatal Screening and Diagnostics
- Polymer Surface Interaction Studies
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Cell Image Analysis Techniques
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Chronic Kidney Disease and Diabetes
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Pluripotent Stem Cells Research
- Anesthesia and Pain Management
- Nerve injury and regeneration
Chengdu University of Traditional Chinese Medicine
2024-2025
China Medical University
2023-2025
Nanjing Drum Tower Hospital
2025
China Pharmaceutical University
2019-2024
Anhui Provincial Hospital
2020-2024
China Southern Power Grid (China)
2024
PetroChina Southwest Oil and Gas Field Company (China)
2024
Army Medical University
2012-2023
Nanjing Medical University
2017-2023
Suzhou Municipal Hospital
2021-2023
We present a new method in image segmentation that is based on Otsu's but iteratively searches for subregions of the segmentation, instead treating full as whole region processing. The iterative starts with threshold and computes mean values two classes separated by threshold. Based values, separates into three standard does. first are determined foreground background they will not be processed further. third class denoted to-be-determined (TBD) at next iteration. At succeeding iteration,...
Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification. Effective chondrogenesis inhibition BMP2-induced osteogenesis ossification can be achieved by directing mesenchymal stem cells (MSCs) towards chondrocyte lineage with chodrogenic factors, such as Sox9. Here we investigated effects Sox9 on differentiation MSCs. We found exogenous...
The sensing and visualized monitoring of hydrogen sulfide (H2S) in vivo is crucial to understand its physiological pathological roles human health diseases. Common methods for H2S detection require the destruction biosamples are not suitable be applied vivo. In this Communication, we report a "turn-on" second near-infrared (NIR-II) luminescent approach sensitive, real-time, situ detection, which based on absorption competition between H2S-responsive chromophores (compound 1) NIR-II...
Background/Aims: Joint cartilage defects are difficult to treat due the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for repair. Bone morphogenetic protein 2 (BMP2) has been shown induce chondrogenic differentiation in mesenchymal (MSCs); however, maintaining phenotypes MSCs during repair since occurs along endochondral ossification pathway. In this study, hypoxia inducible factor, or (HIF)-1α,...
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC). To date, roles lncRNA MEG3 in HCC are not well illustrated. Therefore, this study used western blot qRT-PCR to evaluate expression MEG3, miR-9-5p, Sex determining Region Y-related HMG-box 11 (SOX11) tissues cell lines. pull-down luciferase reporter assay were these molecular interactions....
Earthquakes always leave many surviving teenagers suffering from various mental problems, such as post-traumatic stress disorder (PTSD). We studied the metabolites in current and remitted pediatric PTSD patients healthy controls after an earthquake, aiming to find neurochemistry differences these teenagers.Proton magnetic resonance spectroscopy ((1) H-MRS) was performed anterior cingulate cortex (ACC) of 21 healthy, 10 23 subjects.Significantly lower glutamate + glutamine/creatine (Glx/Cr)...
Radiotherapy (RT) is one of the most common treatments for cancer. However, intracellular glutathione (GSH) plays a key role in protecting cancer from radiation damage. Herein, we have developed platelet membrane biomimetic nanomedicine (PMD) that induces double GSH consumption to enhance tumor radioimmunotherapy. This consists an external and internal organic mesoporous silica nanoparticles (MON) loaded with 2-deoxy-D-glucose (2-DG). Thanks tumor-targeting ability membranes, PMD can target...
Abstract A cell carrier plays an important role in the maintenance, growth and engraftment of specific cells aimed for defined therapeutic uses many tissue engineering strategies. suitable microenvironment allows maximum efficacy hybrid device. We have prepared injectable thermosensitive chitosan/β‐glycerophosphate/collagen (C/GP/Co) gel investigated its potential application as a support culture skeletal muscle satellite (SMSCs). viability assay was used to evaluate vitro cytocompatibility...
For the fault region identification of transformer heat sink, in order to accurately segment abnormal this paper studies a new segmentation method for sink. Firstly, Gaussian filtering and 4-direction Laplace operator are used preprocess infrared image sink get cleaner image, which provides basis subsequent segmentation; then FCM algorithm is pre-segment remove interference background, target with rougher edge; finally, growth finely divide more accurate Finally, faulty obtain different...
Hepatic stellate cells (HSCs) are the main extracellular matrix (ECM)‑producing in liver fibrosis. Activated HSCs stimulate proliferation and migration of hepatocellular carcinoma (HCC) cells. Cysteine‑rich 61 (CCN1/Cyr61) is an ECM protein. Our previous studies demonstrated that expression CCN1 was significantly higher benign hepatic cirrhosis tissue cancer‑adjacent tissues. a target gene β‑catenin HCC promotes The present study aimed to examine whether can activate affect function...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in regulation HCC development great clinical significance. SOX11 a transcription factor belonging to group C Sry-related mobility box family whose abnormal expression frequently seen many kinds human cancers. Here, we noted that was decreased tumors compared matched normal tissues. Overexpression promoted growth inhibition and apoptosis cell line HuH-7....
Radiographically, ground-glass nodules (GGN) and part-solid (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity their clinical manifestations, biological characteristics, prognosis. This study aimed to explore the of LUAD different radiological phenotypes associated factors influencing tumor evolution. We performed single-cell RNA sequencing (scRNA-seq) on tissues from eight seven cases GGN– PSN–LUAD, respectively, at disease stages, including minimally invasive (MIA), (IAC),...