A5100329752- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Cells and Metastasis
- Acoustic Wave Resonator Technologies
- Analytical Chemistry and Sensors
- Bone Metabolism and Diseases
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Metal complexes synthesis and properties
- Gene expression and cancer classification
- Electrowetting and Microfluidic Technologies
- Advanced Biosensing Techniques and Applications
- Natural product bioactivities and synthesis
- Graphene and Nanomaterials Applications
- Monoclonal and Polyclonal Antibodies Research
- Medicinal Plant Pharmacodynamics Research
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Radio Frequency Integrated Circuit Design
- Mechanical and Optical Resonators
City University of Hong Kong, Shenzhen Research Institute
2016-2025
City University of Hong Kong
2016-2025
Guizhou University
2023-2024
Chinese Academy of Fishery Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Sichuan University
2023
West China Second University Hospital of Sichuan University
2023
National Medical Products Administration
2023
IE University
2020
Mattson Technology (Germany)
2019
Most of the current methods for programmable RNA drug therapies are unsuitable clinic due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could solve these problems because they represent a natural mode intercellular communication. However, cellular sources EV production limited in availability safety terms horizontal gene transfer. One potentially ideal source be human red blood cells (RBCs). Group O-RBCs can used as universal donors large-scale since readily...
Understanding the interaction mechanisms between nanomaterials and biological cells is important for control manipulation of these interactions biomedical applications. In this study, we investigated cellular effects gold nanoparticles (AuNPs) on differentiation mesenchymal stem (MSCs) associated molecular mechanisms. The results showed that AuNPs promoted MSCs toward osteoblast over adipocyte by inducing an enhanced osteogenic transcriptional profile attenuated adipogenic profile. exerted...
Spinal muscular atrophy (SMA) is a common neurodegenerative disease that caused by deletions or loss-of-function mutations in the Survival of Motor Neuron (SMN) protein. SMN part large complex functions assembly/restructuring ribonucleoprotein (RNP) complexes. We recently showed HeLa cells two components complex, Gemin3 and Gemin4, together with argonaute protein eIF2C2, also associate microRNAs (miRNAs) as novel class RNPs termed miRNPs. Here we report on miRNPs isolated from neuronal cell...
The development of cost-effective and versatile sensing system for simultaneous rapid quantitation multiple targets is highly demanded environmental surveillance, food safety inspection, home healthcare, etc. This work reports on (1) paper-based microarrays relying fluorescence turn-off carbon nanodots (CDs) analyte recognition (2) a stand-alone smartphone-based portable reader (SBR) installed with custom-designed APP (SBR-App), which can accurately reproducibly acquire change from the...
Abstract Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some linked to an increase in case numbers globally. However, there is yet a lack understanding the molecular basis for interactions between human ACE2 (hACE2) receptor these VOCs. Here we examined several VOCs including Alpha, Beta, Gamma, demonstrate that five receptor-binding domain (RBD) increased binding affinity hACE2, four pseudoviruses entry into susceptible cells. Crystal structures hACE2-RBD complexes...
Third-generation sequencing can be used in human cancer genomics and epigenomic research. Oxford Nanopore Technologies (ONT) recently released R10.4 flow cell, which claimed an improved read accuracy compared to R9.4.1 cell. To evaluate the benefits defects of cell for profiling on MinION devices, we non-small-cell lung-carcinoma line HCC78 construct libraries both single-cell whole-genome amplification (scWGA) shotgun sequencing. The reads were benchmarked terms accuracy, variant detection,...
Abstract Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of cells, especially from patients with early stage cancer, hindered widespread application this technique. Hence, we developed a digital microfluidic system for drug using cells and established working protocol precision medicine. Smart control logic was to increase throughput decrease its footprint parallelly screen three drugs 4 × cm...
Multipotent mesenchymal stem cells (MSCs) have attracted substantial attention in cell therapy and tissue engineering due to their ability be cultured for successive passages multilineage differentiation. Carbon nanotubes (CNTs) been proposed used as potential biomedical structures bone formation. Therefore, it is important study the mechanisms of interaction between MSCs CNTs. We demonstrated that carboxylated single-walled carbon (SWCNTs) multiwalled (MWCNTs) inhibited proliferation,...
This paper proposes a design approach for broadband and high-efficiency continuous inverse Class-F (CCF-1) power amplifier (PA) based on modified elliptic low-pass filtering (LPF) matching network (MN). From theoretical practical perspectives, the importance of swift impedance transition from higher end fundamental frequency band to lower second harmonic is discussed, when designing single-mode PA. After being compared with widely used Chebyshev LPF MNs, MN, which provides sharp roll-off,...
Abstract Purpose: X protein (HBx), a product of hepatitis B virus, has been closely associated with the development hepatocellular carcinoma (HCC). Based on observations that COOH-terminal truncated HBx was frequently detected in HCC, aim this study is to evaluate function hepatocarcinogenesis. Experimental Design: Expression pattern analyzed by immunohistochemistry tissue microarray containing 194 pairs HCCs and their matched nontumor liver tissues. MIHA HepG2 cells transfected full-length...
A photorefreshable and photoenhanced electrochemical sensing platform for bisphenol (BPA) detection based on Au nanoparticles (NPs) decorated carbon doped TiO2 nanotube arrays (TiO2/Au NTAs) is described. The TiO2/Au NTAs were prepared by quick annealing of anodized nanotubes in argon, followed controllable electrodeposition NPs. decoration NPs not only improved photoelectrochemical behavior but also enhanced electrocatalytic activities the resulted hybrid NTAs. Meanwhile, high...
This paper presents a high-efficiency gallium nitride Doherty power amplifier (DPA) using an integrated compensating reactance (CR) for broadband operation. With additional quarter-wavelength transmission line in the peaking output, CR is generated to compensate load impedance of carrier low-power region and thus enhance back-off efficiency over wide frequency range without affecting modulation at saturation. For this purpose, output matching network (OMN) employed convert device into...
Background: Malignant glioma is a fatal brain cancer. Accumulated evidence has demonstrated that exosomes can cross the blood–brain barrier (BBB), suggesting their potential use as drug delivery vehicles to glioma. Therefore, various loading methods of anticancer agents into have been developed. However, efficiency drugs, such doxorubicin (DOX) and paclitaxel (PTX), relatively low, thus challenging improve cells (GMs) via exosomes. Methods: To exosomes, microfluidic device (Exo-Load) was...