A5072510066- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Retinal Diseases and Treatments
- Lymphatic System and Diseases
- Parathyroid Disorders and Treatments
- Retinal Development and Disorders
- Fluorine in Organic Chemistry
- CRISPR and Genetic Engineering
- Erythropoietin and Anemia Treatment
- Barrier Structure and Function Studies
- Iron Metabolism and Disorders
- Aortic aneurysm repair treatments
- Titanium Alloys Microstructure and Properties
- Peripheral Artery Disease Management
- Connexins and lens biology
- Inorganic Fluorides and Related Compounds
- Retinal and Macular Surgery
- Sports Performance and Training
- Lymphatic Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Tryptophan and brain disorders
- Hedgehog Signaling Pathway Studies
- Virus-based gene therapy research
- Testicular diseases and treatments
Beijing Sport University
2022-2024
Heidelberg University
2020-2024
Heidelberg University
2024
University Hospital Heidelberg
2020-2024
German Center for Pediatric and Adolescent Rheumatology
2021-2023
University of Science and Technology Beijing
2023
Shanghai Tenth People's Hospital
2015-2022
Tongji University
2015-2022
Xuzhou Medical College
2019-2022
Huazhong University of Science and Technology
2007-2021
Abstract Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results end-stage disease (ESRD). There is new focus on lymphangiogenesis field inflammation. Recent studies have revealed association between but source lymphatic endothelial cells (LECs) not clear. It has also been reported that macrophages are involved through direct indirect mechanisms other tissues. We hypothesized there was close relationship progenitor fibrosis. In this...
Abstract Background Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced TGF-β families. Migrasome recently discovered type extracellular vesicle related to cell migration. Results Here, we used ex vivo, in vitro, and vivo models, investigate characteristics functions migrasomes RPE PVR development. indicated that migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed human...
Abstract Proliferative vitreoretinopathy (PVR) is a disease that causes severe blindness and characterized by the formation of contractile fibrotic subretinal or epiretinal membranes. The epithelial-mesenchymal transition (EMT) retinal pigment epithelial (RPE) cells hallmark PVR. This work aims to examine role long noncoding RNA (lncRNA) named EMT-related lncRNA in RPE (ERLR, LINC01705-201 (ENST00000438158.1)) PVR explore underlying mechanisms. In this study, we found ERLR upregulated...
Understanding and targeting the molecular basis of peritoneal solute protein transport is essential to improve dialysis (PD) efficacy patient outcome. Supplementation PD fluids (PDF) with alanyl-glutamine (AlaGln) increased small reduced loss in a recent clinical trial. Transepithelial resistance 10 kDa 70 dextran were measured primary human endothelial cells (HUVEC) exposed conventional acidic, glucose degradation products (GDP) containing PDF (CPDF) low GDP (LPDF) without AlaGln. Zonula...
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Enantioselective electrophilic difluoromethylation by phase transfer catalysis.
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory antitumor activities. HMGB1 newly discovered danger-associated molecular pattern (DAMP) that proinflammatory effects once released by necrotic cells. However, the effect of GSPE on HMGB1, relationship those two with acute kidney injury chronic fibrosis are unknown. This study aimed to investigate impact fibrosis. C57bl/6...
Summary Cryptorchidism, characterized by the presence of one (unilateral) or both (bilateral) undescended testes, is a common male urogenital defect. Cryptorchidism can lead to infertility, testicular cancer being most extreme clinical symptom, as well psychological issues inflicted individual. Despite this, knowledge about aetiology cryptorchidism and mechanism for cryptorchidism-induced infertility remain limited. In this present study, using an artificial cryptorchid mouse model, we...
Vascular endothelial growth factor C (VEGF-C) is an angiogenic and lymphangiogenic factor. Recent research has revealed the role for VEGF-C in regulating autophagy by interacting with a nontyrosine kinase receptor, neuropilin-2 (NRP-2). However, whether participates cell survival renal proximal tubular cells unknown. To address this question, we employed modal of serum deprivation to verify its receptor NRP-2 NRK52E lines. The results show that rescued loss viability induced...
Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The paracellular permeability depends on composition spatial distribution cell-to-cell tight junctions (TJ). Here, we provide an experimental workflow that yields several layers data in setting a single endothelial cell monolayer. Human umbilical vein cells were grown Transwell filters. Transendothelial electrical resistance (TER) 10 kDa FITC dextran flux measured using Alanyl-Glutamine...
Next to the skin, peritoneum is largest human organ, essentially involved in abdominal health and disease states, but information on peritoneal paracellular tight junctions transcellular channels transporters relative transmembrane transport scant. We studied their localization quantity by immunohistochemistry confocal microscopy health, chronic kidney (CKD) dialysis (PD), with latter allowing for functional characterizations, a total of 93 individuals (0-75 years). Claudin-1 -5, -15, zonula...
The peroxisome proliferator‑activated receptor γ (PPARγ) agonist pioglitazone has been widely used in previous studies to ameliorate diabetes mellitus and regulate inflammation. However, the present study aimed investigate effect of on macrophages determine its impact renal fibrosis vivo. Firstly, bone marrow‑derived (BMDM) were detect effects vitro. It was demonstrated that promoted M2 macrophage activation induced vascular endothelial growth factor 3 (VEGFR3) upregulation a PPARγ‑dependent...
Diabetic retinopathy (DR), a common microvascular complication of diabetes, is reported to be the leading cause blindness worldwide. In our previous study, we found that Raf kinase inhibitor protein (RKIP) significantly decreased in vitreous humor proliferative diabetic (PDR) patients, which indicated RKIP might play role development PDR. To investigate PDR, stable overexpression and knockdown Human retinal capillary endothelial cells (HRCECs) were generated by using lentivirus constructs....
ABSTRACT Background The unphysiological composition of peritoneal dialysis (PD) fluids induces progressive fibrosis, hypervascularization and vasculopathy. Information on these alterations after kidney transplantation (KTx) is scant. Methods Parietal tissues were obtained from 81 pediatric patients with chronic disease stage 5 (CKD5), 72 children PD low glucose degradation product (GDP) fluids, 20 4–8 weeks KTx preceding low-GDP PD. Tissues analyzed by digital histomorphometry quantitative...
Male germline stem cells (MGSCs) are a subpopulation of germ in the testis tissue. MGSCs capable differentiation into spermatozoa and thus perfect targets for genomic manipulation to generate transgenic animals. The present study was optimize protocol production mice through transduction vivo using lentiviral-based vectors. recombinant lentiviral vectors with either EF-1 or CMV promoter drive expression enhanced green fluorescent protein (eGFP) transgene were injected seminiferous tubules...