A5100366745- Spine and Intervertebral Disc Pathology
- Acupuncture Treatment Research Studies
- Spinal Fractures and Fixation Techniques
- Traditional Chinese Medicine Studies
- Immune Cell Function and Interaction
- Scoliosis diagnosis and treatment
- Immunotherapy and Immune Responses
- Musculoskeletal pain and rehabilitation
- COVID-19 Clinical Research Studies
- Berberine and alkaloids research
- Thyroid and Parathyroid Surgery
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Complement system in diseases
- Ginseng Biological Effects and Applications
- Immune cells in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- COVID-19 and healthcare impacts
- Heart Rate Variability and Autonomic Control
- IL-33, ST2, and ILC Pathways
- Alkaloids: synthesis and pharmacology
Shanghai East Hospital
2017-2025
Central South University
2025
University of Jinan
2021-2025
Jiangsu University
2013-2025
Union Hospital
2016-2024
Huazhong University of Science and Technology
2016-2024
Anhui University of Traditional Chinese Medicine
2018-2024
Anhui Medical University
2014-2024
Union Hospital
2018-2023
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2021-2023
Abstract Background Information on kidney impairment in patients with coronavirus disease 2019 (COVID-19) is limited. This study aims to assess the prevalence and impact of abnormal urine analysis dysfunction hospitalized COVID-19 Wuhan. Methods We conducted a consecutive cohort admitted tertiary teaching hospital 3 branches following major outbreak Wuhan 2020. Hematuria, proteinuria, serum creatinine concentration other clinical parameters were extracted from electronic hospitalization...
Abstract Background This study aimed to develop mortality-prediction models for patients with coronavirus disease-2019 (COVID-19). Methods The training cohort included consecutive COVID-19 at the First People’s Hospital of Jiangxia District in Wuhan, China, from 7 January 2020 11 February 2020. We selected baseline data through stepwise Akaike information criterion and ensemble XGBoost (extreme gradient boosting) model build models. then validated these by randomly collected Union Hospital,...
In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, TILs do not routinely express IL10, as autocrine complement C3 inhibits production through receptors C3aR C5aR. from C3-deficient mice, however, exhibit enhanced effector function. mice are resistant tumor development in a T-cell- IL10-dependent manner; human expanded with IL2 plus increase the killing of primary tumors vitro compared...
Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β associated with intervertebral degeneration; however, the molecular mechanisms that drive production in disc, especially nucleus pulposus (NP) cells, are unknown. In some tissues, advanced glycation end products (AGEs), which accumulate NP tissues promote its degeneration, increase oxidative stress secretion,...
Changes in platelet count are common COVID-19 patients. The reflects the thrombocyte turnover, acting as a sensitive indicator of illness severity that is great clinical utility to monitor quickly changing health condition patients affected by aggressive viral infections. This study aims investigate significance during progression disease patients.A total 532 were involved cohort from First People's Hospital Jiangxia District Wuhan January 7, 2020, February 28, 2020. We collected...
Background: COVID-19 has caused a large number of deaths in short period and lacks specific treatment. Early identification poor prognosis patients may facilitate doctors to offer proper supportive treatment advance. This study aimed develop death prediction models for patients. Methods: In this cohort study, participants were who had been hospitalized the First People's Hospi predictive tal Jiangxia District Wuhan from January 7, 2020 February 11, 2020. Clinical characteristics laboratory...
Extracellular vesicles (EVs) are potential alternatives for mesenchymal stem cells (MSCs) in the treatment of musculoskeletal degenerative diseases, including intervertebral disc degeneration (IDD). Usually, EVs internalized and then deliver bioactive molecules that impart phenotypic changes recipient cells. For effective utilization IDD therapy, understanding mechanism EV uptake is vital importance. In this study, we found delivered antioxidant proteins to protect against pyroptosis nucleus...
Complement synthesis in cells of origin is strongly linked to the pathogenesis and progression renal disease. Multiple studies have examined local C3 disease elucidated contribution cellular sources, but infiltrating inflammatory remains unclear. We investigate relationships among C3, macrophages Th17 cells, which are involved interstitial fibrosis. Here, we report that increased expression, mainly by monocyte/macrophages, was detected biopsy specimens correlated with severity fibrosis...
Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed its therapeutic effects. However, as for berberine’s metabolites, especially phase II pharmacokinetics excretion were rarely reported. The objective of this study was thoroughly investigate pharmacokinetic profiles nine namely, berberrubine (M1), demethyleneberberine (M2),...
As the use of pesticides increases year after year, so does level residual in aquatic environment, posing a serious threat to non-target organisms. Difenoconazole (DFZ), class long-lasting fungicides and residues marine has been shown cause damaging effects on different organs However, there is no research damage DFZ carp spleen tissue. This study aimed investigate acute toxic tissue (Cyprinus carpio) by exposing juvenile environmentally relevant concentrations DFZ. We randomly selected 30...
Triple-negative breast cancer (TNBC) is more prone to distant metastasis and visceral recurrence in comparison other subtypes, related dismal prognosis. Nevertheless, TNBC has an undesirable response targeted therapies. Therefore, tackle the huge challenges diagnosis treatment of TNBC, Nectin-4 was selected as a theranostic target because it recently found be highly expressed TNBC. We developed anti-Nectin-4 monoclonal antibody (mAbNectin-4)-based pair, 99mTc-HYNIC-mAbNectin-4...
Background It has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to relationship T2DM explore predictive characteristics TyG-BMI. Methods Our was conducted as longitudinal cohort study. 8,430 men 7,034 women were enrolled analyzed. They both non-diabetic subjects with...
Abstract Elimination of bacterial infections and simultaneously promoting osteogenic differentiation are highly required for infectious bone diseases. Massive reactive oxygen species (ROS) can damage cells, while low ROS concentrations as a molecular signal regulate cellular fate. In this study, Janus‐ROS healing system is developed regeneration. An alendronate (ALN)‐mediated defective metal–organic framework (MOF) sonosensitizer prepared, which effectively clear Methicillin‐resistant...
Increased tissue stiffness is associated with various pathological processes, such as fibrosis, inflammation, and aging. The matrix of the nucleus pulposus (NP) tissues increases gradually during intervertebral disc degeneration (IDD), while mechanism through which NP cells sense react to remains unclear. In this study, results indicate that ferroptosis involved in stiff substrate-induced cell death. expression acyl-CoA synthetase long-chain family member 4 (ACSL4) group, mediates lipid...
Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles...
Myocardial infarction (MI) resulting from coronary artery occlusion is the leading global cause of cardiovascular disability and mortality. Anti-inflammatory treatment plays an important role in MI treatment. Triptolide (TPL), as a Chinese medicine monomer, has variety biological functions, including anti-inflammatory, anti-tumor, immunoregulation. However, it been proved that TPL poorly water soluble, clear hepatotoxicity nephrotoxicity, which seriously limits its clinical application....
Abstract CD8 + T-cell exhaustion is a state of dysfunction that promotes tumor progression and marked by the generation Slamf6 progenitor exhausted (Tex prog ) Tim-3 terminally term subpopulations. Inhibitor DNA binding protein 2 (Id2) has been shown to play important roles in development immunity. However, role Id2 unclear. Here, we found transcriptionally epigenetically regulates Tex cells their conversion cells. Genetic deletion dampens T-cell-mediated immune responses maintenance...
Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but their delivery efficiency biological activity require optimization. This study aims to develop targeted nanozyme system MIRI treatment by integrating CeO2 with mesoporous polydopamine (mPDA) dexrazoxane (DXZ) achieve synergistic therapeutic effects. A...
Intervertebral disc degeneration (IDD) is the primary culprit of low back pain and renders heavy social burden worldwide. Pyroptosis a newly discovered form programmed cell death, which also involved in nucleus pulposus (NP) cells during IDD progression. Moderate autophagy activity critical for NP survival, but its relationship with pyroptosis remains unknown. This study aimed at investigating between pyroptotic death. The executor N-terminal domain gasdermin D (GSDMD-N) inflammation-related...
Abstract Background Injectable hydrogels have great promise in the treatment of myocardial infarction (MI); however, lack electromechanical coupling hydrogel to host tissue and inability monitor implantation may compromise a successful treatment. The introduction conductive biomaterials mesenchymal stem cells (MSCs) solve problem they been used treat MI. In this study, we developed an injectable nanocomposite (GNR@SN/Gel) fabricated by gold nanorods (GNRs), synthetic silicate nanoplatelets...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical that currently has no effective therapeutic interventions. Pulmonary macrophages play principal role in the initiation and progression of overwhelming inflammation ALI/ARDS. Here, type fluorous‐tagged bioactive peptide nanoparticle termed CFF13F developed, which can be efficiently internalized by suppress excessive expression cytokines overproduction reactive oxygen species (ROS) triggered...