A5103067447- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Caveolin-1 and cellular processes
- Clusterin in disease pathology
- Vasculitis and related conditions
- Lipid metabolism and disorders
- Complement system in diseases
- Cell Adhesion Molecules Research
- Lymphatic System and Diseases
- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- Platelet Disorders and Treatments
- Innovative concrete reinforcement materials
- Acute Kidney Injury Research
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Structural Behavior of Reinforced Concrete
- Inflammasome and immune disorders
- Chronic Lymphocytic Leukemia Research
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
Tianjin Chengjian University
2024
Tongji Hospital
2014-2024
Huazhong University of Science and Technology
2014-2024
Beijing Information Science & Technology University
2019
Liaocheng University
2017-2018
Cell Technology (China)
2017-2018
Materials Science & Engineering
2017-2018
Novel (United States)
2018
The First People's Hospital of Guiyang
2009
Hunan University of Science and Engineering
2004
Complement synthesis in cells of origin is strongly linked to the pathogenesis and progression renal disease. Multiple studies have examined local C3 disease elucidated contribution cellular sources, but infiltrating inflammatory remains unclear. We investigate relationships among C3, macrophages Th17 cells, which are involved interstitial fibrosis. Here, we report that increased expression, mainly by monocyte/macrophages, was detected biopsy specimens correlated with severity fibrosis...
Expanded lymphatic vessels (LVs) in kidneys and renal draining lymph nodes (RDLNs) promote intrarenal inflammation fibrosis.
<b><i>Background:</i></b> Renal tubulointerstitial fibrosis is the final common stage of renal failure. CD4+ T lymphocyte recruitment and activation after injury could be very important early event that mediates onset fibrogenesis. But role lymphocytes in controversial its cellular mechanism needs to further investigated. <b><i>Methods:</i></b> Biopsy specimens were from patients with minimal-change or IgA nephropathy. Mouse was induced by...
Background and objectives Previous studies have identified inflammatory features that enable the prediction of renal outcome IgA nephropathy (IgAN); however, validation these findings is still needed. This prospective study was performed to determine characteristics interstitial infiltration tertiary lymphoid organ (TLO) neogenesis in a cohort Chinese patients with IgAN. Design, setting, participants, & measurements Adult IgAN were recruited into this from June 2009 2010. Inflammatory cells...
Abstract Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results end-stage disease (ESRD). There is new focus on lymphangiogenesis field inflammation. Recent studies have revealed association between but source lymphatic endothelial cells (LECs) not clear. It has also been reported that macrophages are involved through direct indirect mechanisms other tissues. We hypothesized there was close relationship progenitor fibrosis. In this...
Since the Coronavirus Disease 2019 (COVID-19) outbreak, there is accumulating data on clinical characteristics, treatment strategies and prognosis of COVID-19 in patients with concurrent renal disease. Postmortem investigations reveal involvement COVID-19, most recently, several biopsy researches that acute tubular injury, as well glomerular nephropathy such collapsing glomerulopathy were common histological findings. However, to our best knowledge, limited regarding IgA setting COVID-19.In...
N-acetylcysteine has been widely used as a nutritional supplement and drug in humans for its antioxidant properties. The complement activation fragment C5a is strong proinflammatory molecule that mediates cell adhesion, chemotaxis, the complex biological functions. However, effect of NAC on C5a, relationship those two with cisplatin-induced acute kidney injury are unknown. In cisplatin induced AKI mouse model, mice administration had marked improvement renal function (BUN Cr), decreased...
The purpose of this study is to investigate the changing spectrum and clinicopathologic correlation biopsy-proven renal diseases in central China. We retrospectively analyzed data 4931 patients who underwent biopsy ten hospitals between September 1994 December 2014. Among them, 81.55% were primary glomerular (GD), 13.02% secondary GD. IgA nephropathy (IgAN) was most common GD (43.45%), followed by focal glomerulonephritis (16.79%), mesangial proliferative (MsPGN, 14.35%), membranous (MN,...
Abstract Background Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression role of LRG1 lupus nephritis (LN). Methods Plasma (pLRG1) was measured by enzyme-linked immunosorbent assay 101 patients with renal biopsy-proven LN 21 healthy controls (HC). Relationships between pLRG1 clinical pathological characteristics were analyzed. The peripheral blood leukocytes kidney detected flow cytometry,...
Endothelial-to-mesenchymal transition (EndMT) contributes to the emergence of fibroblasts and plays a significant role in renal interstitial fibrosis. Protein phosphatase 2A (PP2A) is major serine/threonine protein eukaryotic cells regulates many signaling pathways. However, significance PP2A EndMT poorly understood. In present study, was evaluated. We demonstrated that activated endothelial (EC) during their phenotype acquisition mouse model obstructive nephropathy (i.e., UUO). Inhibition...
Background: Tertiary lymphoid organs (TLOs) occur after multiple chronic kidney injuries. interleukin-17A (IL-17A) has been reported to associate with the development of TLOs in inflammatory diseases. However, regulation renal and its clinical significance pathogenesis injury are unknown. Methods: To evaluate TLOs, we analyzed progression patients damage based on existence absence a larger multicenter cohort. We also blocked recruitment lymphocyte cells into by FTY720 (fingolimod) vivo....
Increasing evidence has demonstrated that loss of peritubular capillaries plays a critical role in renal interstitial fibrosis. Leucine-rich α2-glycoprotein-1 (LRG1) been observed promoting angiogenesis the ocular disease mouse model and myocardial infarction model. We aimed to explore LRG1 fibrosis.We analyzed expression plasma kidney CKD patients by ELISA immunohistochemistry. Relationships between fibrosis inflammation were analyzed. Tube formation assay was used detect human umbilical...
Renal lymphangiogenesis is a new field of international nephrology in recent years and plays an important role the progression chronic renal disease.CD137 was originally described as surface molecule present on activated T NK cells detected hypoxic endothelial inflamed blood vessels, but its function lymphatic remains unclear.We investigated relationships among CD137, macrophages, which are involved interstitial fibrosis.Similar to other inflammatory diseases, we found expression CD137...
Aims Glomerular complement 3 (C3) deposition is often observed in renal biopsies of patients with IgA nephropathy (IgAN); however, the relationship between intensity C3 and long‐term prognosis IgAN has rarely been reported. In this retrospective study, we aimed to evaluate prognostic value glomerular for progression. Methods results From June 2009 2010, a total 136 adult were enrolled study. According deposition, divided into high group (34 patients) low (102 patients). The levels clinical...
Abstract Purpose Platelet-to-lymphocyte ratio (PLR) was established showing the poor prognosis in several diseases, such as malignancies and cardiovascular diseases. But limited study has been conducted about prognostic value of PLR on long-term renal survival patients with Immunoglobulin A nephropathy (IgAN). Methods We performed an observational cohort enrolling biopsy-proven IgAN recorded from November 2011 to March 2016. The definition composite endpoint eGFR decrease by 50%, < 15...
Three-dimensional (3D) graphene composites have drawn increasing attention in energy storage/conversion applications due to their unique structures and properties. Herein, we synthesized 3D honeycomb-like Ni 3 S 2 @graphene oxide composite (3D @GO) by a one-pot hydrothermal method. We found that positive charges of 2+ negative NO − Ni(NO ) induced transformation with smooth surface into wrinkled (w-GO). The w-GO the mixing solution /thioacetamide/H O evolved @GO solvothermal process. GO...
A recognized noninvasive biomarker to improve risk stratification of immunoglobulin nephropathy (IgAN) patients is scarce. Fractalkine has been shown play a key role in glomerular disease as chemoattractant, adhesion and even fibrosis factor. The current study assessed the possibility plasma fractalkine novel IgAN patients.Plasma was measured 229 with renal biopsy consistent from 2012 2014, clinical, pathological prognostic relationships were analyzed.The levels significantly correlated...
Microangiopathy (MA) lesions are not rare in immunoglobulin A nephropathy (IgAN) and have been suggested to a potential role increasing risk renal function decline. However, this suggestion has universally accepted. We aimed investigate its our cohort multiple studies through systematic meta-analysis. This study included 450 IgAN patients, confirmed by biopsy, at Tongji Hospital, China, from January 2012 December 2016. Clinical data were collected analysed. systematically searched PubMed Web...
Epoxy resin concrete, characterized by its superior mechanical properties, is frequently utilized for structural reinforcement and strengthening. However, application in members remains limited. In this paper, the bond–slip behavior between steel epoxy concrete was investigated using a combination of experimental research finite element analysis, with objective providing data support substantiating expanded use members. The methodology included 18 center-pullout tests 14 model calculations,...
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory antitumor activities. HMGB1 newly discovered danger-associated molecular pattern (DAMP) that proinflammatory effects once released by necrotic cells. However, the effect of GSPE on HMGB1, relationship those two with acute kidney injury chronic fibrosis are unknown. This study aimed to investigate impact fibrosis. C57bl/6...
DSCs based on Fe<sub>1−x</sub>S@S-GO–NMC cathode achieved a high solar-to-electrical conversion efficiency up to 7.23%.
The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and used as a prognostic factor of renal function progression. aim this study was to explore whether circulating suPAR antineutrophil cytoplasmic autoantibody- (ANCA-) vasculitis (AAV) disease activity.We evaluated 90 AAV patients follow-up data 35 normal controls; their plasma C-reactive protein (CRP) levels were measured by ELISA. Associations between these levels, clinical parameters, prognosis...