A5100386124- Acute Kidney Injury Research
- Healthcare Systems and Public Health
- Lymphatic System and Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Acute Ischemic Stroke Management
- Per- and polyfluoroalkyl substances research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Restless Legs Syndrome Research
- Reproductive System and Pregnancy
- Cardiovascular Health and Risk Factors
- Glycosylation and Glycoproteins Research
- Lymphatic Disorders and Treatments
- Gestational Diabetes Research and Management
- Complement system in diseases
- Chronic Disease Management Strategies
- Cardiac Arrest and Resuscitation
- Congenital heart defects research
- Immune Response and Inflammation
- COVID-19 Impact on Reproduction
- Ultrasound in Clinical Applications
- Vascular Malformations and Hemangiomas
Central Hospital of Putuo District
2025
Nanjing Medical University
2024
Huazhong University of Science and Technology
2014-2024
First Affiliated Hospital Zhejiang University
2024
Hebei North University
2022
Tongji Hospital
2015-2021
Wuhan National Laboratory for Optoelectronics
2014
Fujian Normal University
2014
Capital Normal University
2013
Hospital of Hebei Province
2011
Complement synthesis in cells of origin is strongly linked to the pathogenesis and progression renal disease. Multiple studies have examined local C3 disease elucidated contribution cellular sources, but infiltrating inflammatory remains unclear. We investigate relationships among C3, macrophages Th17 cells, which are involved interstitial fibrosis. Here, we report that increased expression, mainly by monocyte/macrophages, was detected biopsy specimens correlated with severity fibrosis...
Abstract Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results end-stage disease (ESRD). There is new focus on lymphangiogenesis field inflammation. Recent studies have revealed association between but source lymphatic endothelial cells (LECs) not clear. It has also been reported that macrophages are involved through direct indirect mechanisms other tissues. We hypothesized there was close relationship progenitor fibrosis. In this...
Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) is associated with blood lipids in adults, but the underlying mechanisms remain unclear. This pilot study aimed investigate associations between PFOA or PFOS epigenome-wide DNA methylation assess mediating effect of on PFOA/PFOS-blood lipid association. We measured plasma PFOA/PFOS leukocyte 98 patients enrolled from hospital October 2018 August 2019. The median levels were 0.85 2.29 ng/mL. Plasma significantly...
As common contaminants, metals are non-negligible risk factors for diabetes and chronic kidney disease. However, whether there is an association between multiple exposure incident disease (CKD) in patients with unclear. We conducted a prospective study to evaluate these associations. In total, 3071 diabetics baseline estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 from the Dongfeng-Tongji cohort were included. measured plasma concentrations of 23 investigated associations...
N-acetylcysteine has been widely used as a nutritional supplement and drug in humans for its antioxidant properties. The complement activation fragment C5a is strong proinflammatory molecule that mediates cell adhesion, chemotaxis, the complex biological functions. However, effect of NAC on C5a, relationship those two with cisplatin-induced acute kidney injury are unknown. In cisplatin induced AKI mouse model, mice administration had marked improvement renal function (BUN Cr), decreased...
Previous evidences exploring the associations of BPA with lipid changes and dyslipidemia did not obtain consistent results. To evaluate whether serum concentration was associated in blood levels incident risk middle-elderly Chinese adults, we conducted a prospective study 1093 participants (average 62.65 years old) derived from Dongfeng-Tongji cohort which founded 2008 followed up each 5 years. Serum were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS)....
Chronic kidney disease (CKD) is a common comorbidity among patients with type 2 diabetes. Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been linked poorer function in general population, but the related studies individuals diabetes were very limited. We aimed examine longitudinal associations of PFOA PFOS exposure CKD incidence patients. Baseline levels measured serum 967 from Dongfeng-Tongji cohort. Multivariable logistic regression models used...
Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and related to intracerebral hemorrhage. Because statin therapy is associated increased risk of hemorrhage, we investigated whether use was also microhemorrhages acute ischemic stroke or transient attack.We performed a retrospective analysis prospectively collected data from registry containing attack. The primary secondary outcome variables were the prevalence degree as...
To explore the feasibility of using enhanced-flow (e-flow) imaging technology to identify fetal pulmonary veins and establish gestational age-specific reference values at 12-40 weeks' gestation.The venous internal diameter, peak systolic diastolic flow velocities visualization rate were analyzed in 332 normal fetuses weeks gestation. Two-dimensional gray-scale (2D) ultrasound, color Doppler e-flow used detect four-chamber view by taking lung as penetration window.The could be visualized...
Maffucci's syndrome is characterized by the coexistence of multiple enchondromas and soft-tissue hemangiomas. It has been clear that somatic mosaic isocitrate dehydrogenase type 1 (IDH1) or 2 (IDH2) mutations are associated with Ollier disease, but mechanisms underlying hemangiomas still obscure. This study aimed to determine mechanism in syndrome.We received a 26-year-old female patient typical syndrome, exome sequencing was conducted using DNA from her peripheral blood enchondroma tissues....
Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants to induce robust responses against the target pathogen. Thus, selection of plays a crucial role in design protein vaccines. Recently, there has been growing interest utilizing cGAS-STING agonists as vaccine adjuvants. In this study, we investigated adjuvant effect manganese (Mn), agonist, tuberculosis Bfrb-GrpE (BG) mouse model. Initially, mice were administered with...
Researchers have developed several equations to predict glomerular filtration rate (GFR) in patients with chronic kidney diseases (CKD). However, there are scarcely any studies performed discern the best equation estimate GFR pure obstructive nephropathy. In present study, we assessed suitability of six prediction and compared their performance eGFR evaluation for Chinese A total 245 adult nephropathy were enrolled. We evaluated 3 Modification Diet Renal Disease (MDRD) (the original MDRD7,...
Abstract Aims Our objective was to investigate the association of common variants in coding region advanced glycosylation end‐product specific receptor (RAGE) and prognosis heart failure (HF). Methods results A total 3394 HF patients were continuously enrolled from January 2009 August 2018 with a median follow‐up 20.4 months. Additionally, 2861 healthy subjects also participated study. By sequencing these two groups, we identified functional missense variant rs2070600 RAGE, which showed...
Coronavirus disease 2019 (COVID-19) arises from infection with the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[1] The susceptible population can be of any age and gender; thus, threatens health life everyone, including pregnant women. Pregnancy influence physiological function various organs, thus may affect prognosis many infectious diseases. For example, higher mortality rates more complications were reported in patients infected SARS-CoV than those non-pregnant...
Objective: To explore the association of glycosylated hemoglobin (HbA1c) level at admission with 90 days functional outcome in patients spontaneous intracerebral hemorrhage (ICH). Methods: Patients admitted to Department Neurology, Tongji Hospital from January December 2017 were prospectively and continuously enrolled this study. Clinical data collected outcomes after ICH assessed by using modified RANKIN scale. Univariate multivariate conditional logistic regression models constructed....
The application of emergency nursing process in intravenous thrombolytic therapy for patients with acute myocardial infarction was discussed. 100 ST segment elevation who met the inclusion and exclusion criteria were selected thrombolysis. 50 treated from December 2018 to June 2019. first-aid time treatment effect two groups compared. results showed that first aid optimized group less than conventional flow (P < 0.05); ECG rate higher within 10 min 0.05). It indicates standardized meticulous...
Objective: To explore the establishment of an objective, standardised and operable comprehensive evaluation assessment system for clinical nurses based on support information technology platform to realise management tier before after promotion. Methods: By reviewing literature combining findings with actual situation nursing work in hospitals, nurse criteria were designed assessed at different levels terms their medical ethics, attendance, performance, theoretical study, professional skills...