A5062963970- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Genomics, phytochemicals, and oxidative stress
- Advances in Cucurbitaceae Research
- Biological Activity of Diterpenoids and Biflavonoids
- Marine Sponges and Natural Products
- Redox biology and oxidative stress
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Legume Nitrogen Fixing Symbiosis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- 14-3-3 protein interactions
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Microtubule and mitosis dynamics
- Phytochemical compounds biological activities
- Plant Molecular Biology Research
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Heat shock proteins research
- Fungal Biology and Applications
Huazhong University of Science and Technology
2017-2025
Jiangsu University
2024-2025
Affiliated Hospital of Jiangsu University
2024-2025
Xuzhou Medical College
2022-2025
Zhejiang Chinese Medical University
2024-2025
Shenyang Agricultural University
2008-2025
Northwest A&F University
2023-2024
Hubei University of Chinese Medicine
2021-2024
Huazhong Agricultural University
2005-2024
Hubei University of Medicine
2017-2024
Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant have also been shown to antitumor properties. With genomics biochemistry, we identified nine cucumber genes pathway for biosynthesis of cucurbitacin C elucidated four catalytic steps. We discovered transcription factors Bl ( Bitter leaf ) Bt fruit regulate this leaves fruits, respectively. Traces genomic...
Abstract Background Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioma stem cells (GSCs). Self-renewal is complex biological process necessary for maintaining the cells. Nuclear factor rythroid 2-related 2(Nrf2) plays significant role in protecting from endogenous and exogenous stresses. Nrf2 key nuclear transcription regulates antioxidant response element (ARE)-containing genes. Previous studies have demonstrated of proliferation...
The present investigation was carried out to elucidate a possible molecular mechanism related the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis role nuclear factor erythroid 2-related 2 (Nrf2) in biogenesis. Recently, has been proved have mitochondria damage after traumatic brain injury (TBI). However, its precise and underlying mechanisms are not yet fully understood. aim study investigate...
Background: The neuroprotective effects of Baicalin have been confirmed in several central nervous system (CNS) diseases. However, its possible effect on traumatic brain injury (TBI) model is still not clear. present study aimed to investigate the role and underling mechanisms 7-d-glucuronic acid-5,6-dihydroxyflavone (Baicalin) TBI model. Methods: weight-drop Institute Cancer Research mice was treated with intraperitoneally at 30 minutes after TBI. LY294002 (LY) (a commonly used PI3K/Akt...
Human gastric cancer is a highly lethal disease, but the underlying multiomic molecular signatures remain largely unclear. Here, we performed multi-regional sampling, parallel single-cell multiomics sequencing and integrated analyses of human cancer. We identified common transcriptomic alterations cells, such as aberrant down-regulation genes associated with normal stomach function up-regulation KRT7, PI3, S100A4, etc. Surprisingly, prevalent expressed in colorectal epithelial cells were...
Peroxiredoxins are a family of antioxidant enzymes conserved from bacteria to humans. In Saccharomyces cerevisiae, there exist five peroxiredoxins, among which Tsa2p shares striking homology with the well described Tsa1p but has not been extensively studied. Here we report on functional characterization yeast tsa2Δ mutants and comparison ofTSA1 TSA2. The andtsa1Δ cells grew normally under aerobic conditions. However, tsa1Δtsa2Δ mutant was more susceptible oxidants than either tsa1Δ or cells....
TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore expression pattern TEAD family in gastric carcinogenesis investigate its regulation by microRNAs (miRNAs). The mRNA protein were examined quantitative reverse transcription-PCR (qRT-PCR) western blot. Their roles determined vitro vivo studies. clinicopathological association TEAD4 cancer...
Acute kidney injury (AKI) is a serious disease characterized by rapid decline in function. Oxidative stress the primary pathogenesis of AKI. Salvianolic acid B (SalB), water-soluble compound extracted from Salvia miltiorrhiza, possesses potent antioxidant activity. Here, we investigated protective effect SalB against renal ischemia-reperfusion (I/R) mice. Briefly, analyzing function, oxidative markers and inflammatory biomarkers, found that could improve damage, reduce factor levels....
Chronic glomerulonephritis (CGN) is one of the major causes end-stage kidney disease. Zhen-wu-tang (ZWT), as a famous Chinese herbal prescription, widely used in China for CGN therapy clinic. However, mechanism ZWT has not been fully understood. The present study explored therapeutic effect and underlying on mitochondrial function cationic bovine serum albumin (C-BSA)-induced model rats tumor necrosis factor (TNF-α)-damaged mouse podocytes. renal functions were measured by creatinine (Scr)...
Waterlogging causes a significant reduction in soil oxygen levels, which turn negatively affects nutrient use efficiency and crop yields. Rhizosphere microbes can help plants to better nutrients thus adapt this stress, while it is not clear how the plant-associated respond waterlogging stress. There are also few reports on whether response influenced by different sequencing methods soils. In study, using partial 16S rRNA targeting V4 region two full-length approaches V1 V9 regions, effects...
Abstract Wolfberry (fruit of Lycium barbarum Linn) has been known for balancing ‘Yin’ and ‘Yang’ in the body, nourishing liver kidney, improving visual acuity more than 2,500 years oriental countries. The active components wolfberry include L. polysaccharide (LBP), zeaxanthine, betaine, cerebroside trace amounts zinc, iron, copper. Each them confers distinct beneficial effects together they help to explain widespread use eastern world. Earlier study reported neuroprotective LBP on retinal...
The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cues. Activation of YAP vascular smooth muscle cells conveys the extracellular matrix stiffness-induced changes phenotype and behavior. Recent studies have established a mechanoreceptive role receptor tyrosine kinase DDR1 (discoidin domain 1) cells.We conduced 5/6 nephrectomy cells-specific Ddr1-knockout mice, accompanied by pharmacological inhibition Hippo LATS1 (large tumor suppressor...