A5040787463- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Retinal Diseases and Treatments
- Flavonoids in Medical Research
- Medicinal Plants and Neuroprotection
- Photoreceptor and optogenetics research
- Corneal surgery and disorders
- Neurogenesis and neuroplasticity mechanisms
- Planarian Biology and Electrostimulation
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Tryptophan and brain disorders
- Saffron Plant Research Studies
- Connexins and lens biology
- Retinal and Optic Conditions
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Biological Activities
- Ocular and Laser Science Research
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2015-2025
Caritas Medical Centre
2024
Jinan University
2017-2019
Wenzhou Medical University
2019
Affiliated Eye Hospital of Wenzhou Medical College
2019
State Key Laboratory of Brain and Cognitive Science
2018
Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental sexual human-to-human transmission. Although the pathogenesis of ZIKV-associated neurological complications has been reported in recent studies, key questions on other clinical manifestations, non-vector-borne transmission potential animal reservoirs ZIKV remain unanswered. We systematically characterized differential cell line susceptibility 18 human 15 nonhuman...
Micro-dissection of rat brain into various regions is extremely important for the study different neurodegenerative diseases. This video demonstrates micro-dissection four major include olfactory bulb, frontal cortex, striatum and hippocampus in fresh tissue. Useful tips quick removal respective to avoid RNA protein degradation tissue are given.
Cigarette smoking has been proposed as a major risk factor for aging-related pathological changes and Alzheimer's disease (AD). To date, little is known how can predispose our brains to dementia or cognitive impairment. This study aimed investigate the cigarette smoke-induced in brains. Male Sprague-Dawley (SD) rats were exposed either sham air 4% smoke 1 hour per day 8 weeks ventilated chamber mimic situation of chronic passive smoking. We found that levels oxidative stress significantly...
Rationale: Retinal ganglion cell (RGC) degeneration is extremely hard to repair or regenerate and often coupled with mitochondrial dysfunction. Mesenchymal stem cells (MSCs)-based treatment has been demonstrated beneficial for RGC against degeneration. However, underlying mechanisms of MSC-provided protection are largely unknown other than neuroprotective paracrine actions. In this study, we sought investigate whether donation from induced pluripotent cell-derived MSC (iPSC-MSCs) could...
Our group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models. Protecting RGCs secondary degeneration is a promising direction therapy glaucoma management. The complete optic nerve transection (CONT) model can be used to study primary of RGCs, while partial (PONT) because and separated location same retina this model; other situations, these types difficult distinguish. In order examine which...
Poly(3,4-ethylene dioxythiophene) (PEDOT) is a promising conductive material widely used for interfacing with tissues in biomedical fields because of its unique properties. However, obtaining high charge injection capability and stability remains challenging. In this study, pristine carbon nanotubes (CNTs) modified by dopamine (DA) self-polymerization on the surface polydopamine (PDA@CNTs) were utilized as dopants PEDOT to prepare hybrid films through electrochemical deposition indium tin...
Electrical stimulation (ES) can be used to manipulate recovery after peripheral nerve injuries. Although biomaterial-based strategies have already been implemented gain momentum for ES and engineer permissive microenvironments neural regeneration, the development of biomaterials specific stimuli-responsive modulation cell properties remains a challenge. Herein, we homogeneously incorporate pristine carbon nanotubes into functional self-assembling peptide prepare hybrid hydrogel with good...
Lycium barbarum glycopeptide (LbGp) is the main bioactive compound extracted from traditional Chinese medicine. L. berries and has been proven to have numerous health benefits, including antioxidative, anti-inflammatory, anticancer, cytoprotective activities. However, antiaging effect of LbGp remains unknown.The lifespan body movement C. elegans were used evaluate on span. The thrashing assay was determine role in Parkinson's disease. To investigate mechanisms LbGp-induced effects, we...
Abstract Wolfberry (fruit of Lycium barbarum Linn) has been known for balancing ‘Yin’ and ‘Yang’ in the body, nourishing liver kidney, improving visual acuity more than 2,500 years oriental countries. The active components wolfberry include L. polysaccharide (LBP), zeaxanthine, betaine, cerebroside trace amounts zinc, iron, copper. Each them confers distinct beneficial effects together they help to explain widespread use eastern world. Earlier study reported neuroprotective LBP on retinal...
One of the major challenges in treating Alzheimer's disease (AD) is its early diagnosis. Increasing data from clinical and animal research indicate that retina may facilitate an diagnosis AD. However, a previous study on 5xFAD (a fast AD model), showing retinal changes before those brain, has been questioned because involvement degeneration allele Pde6b rd1 . Here, we tested parallel, at 4 6 months age, both brain structure function mouse line carries no mutation rd1. In three regions...
Attempts have been made to use cell transplantation and biomaterials promote proliferation, differentiation, migration, survival, as well angiogenesis, in the context of brain injury. However, whether bioactive materials can repair damage caused by ischemic stroke activating endogenous neurogenesis angiogenesis is still unknown. In this study, we applied chitosan gel loaded with basic fibroblast growth factor cavity 7 days after rats. The slowly released factor, which improved local...
Abstract The molecular link between amyloid-β plaques and neurofibrillary tangles, the two pathological hallmarks of Alzheimer’s disease, is still unclear. Increasing evidence suggests that peptide activates multiple regulators cell cycle pathways, including transcription factors CDKs E2F1, leading to hyperphosphorylation tau protein. However, exact pathways downstream amyloid-β-induced imbalance are unknown. Here, we show PAX6, a factor essential for eye brain development which quiescent in...
To assess retinal microvascular network impairments in the eyes of mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients with optical coherence tomography angiography (OCTA).Systematic review meta-analysis.A literature search was conducted PubMed EMBASE databases to identify relevant studies detecting attenuation among AD, MCI cognitively healthy controls (HCs) by OCTA. Data were extracted Review Manager V.5.4 Stata V.14.0.Eight investigations included this meta-analysis, 150...