A5100737816- Heavy Metal Exposure and Toxicity
- Microplastics and Plastic Pollution
- Arsenic contamination and mitigation
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Telomeres, Telomerase, and Senescence
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
- Bryophyte Studies and Records
- Lichen and fungal ecology
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Selenium in Biological Systems
- Immune cells in cancer
- RNA Research and Splicing
- Clusterin in disease pathology
- Parasites and Host Interactions
Central South University
2020-2025
Shanghai First People's Hospital
2024-2025
Jilin Agricultural University
2023-2025
Shanghai Jiao Tong University
2019-2025
Peking University
2021-2024
Capital Medical University
2016-2024
University of Hong Kong
2020-2024
Guangzhou Medical University
2014-2024
Fourth People's Hospital of Shenzhen
2024
Huazhong University of Science and Technology
2023-2024
Hepatocellular carcinoma (HCC) is characterized by active angiogenesis and metastasis, which account for rapid recurrence poor survival. There frequent down-regulation of miR-195 expression in HCC tissues. In this study, the role metastasis was investigated with vitro capillary tube formation transwell assays, vivo orthotopic xenograft mouse models, human specimens. Reduction tissues significantly associated increased angiogenesis, worse recurrence-free Both gain-of-function loss-of-function...
Importance The lack of evidence-based implementation strategies is a major contributor to increasing mortality due out-of-hospital cardiac arrest (OHCA) in developing countries with limited resources. Objective To evaluate whether the legislation associated increased bystander cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) use improved clinical outcomes for patients experiencing OHCA provide policy implications low-income middle-income settings. Design,...
MicroRNAs (miRNAs) have been proven to play crucial roles in cancer, including tumor chemotherapy resistance and metastasis of non-small-cell lung cancer (NSCLC). TGFβ signal pathway abnormality is widely found correlates with proliferation, apoptosis metastasis. Here, miR-17, 20a, 20b were detected down-regulated A549/DDP cells (cisplatin resistance) compared A549 sensitive). Over-expression can not only decrease cisplatin-resistant but also reduce migration by inhibiting...
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n' Collar basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, oxidative stress. Additionally, involved immune system development. More importantly, highly plays a key role numerous malignant tumors, affecting cellular metabolism, tumor invasion metastasis, proliferation, different cell death pathways, drug...
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation SOX members closely associated tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research investigate mechanisms functions...
This study investigates the value of fluorine 18 ([18F])-labeled fibroblast activation protein inhibitor (FAPI) for lymph node (LN) metastases in patients with stage I-IIIA non-small cell lung cancer (NSCLC). From November 2021 to October 2022, 53 NSCLC who underwent radical resection were prospectively included. [18F]-fluorodeoxyglucose (FDG) and [18F]FAPI examinations performed within one week. LN staging was validated using surgical pathological findings. [18F]FDG uptake compared Wilcoxon...
// Hongjing Zhao 1, * , Ying He Siwen Li 1 Xiao Sun Yu Wang Yizhi Shao Zhijun Hou and Mingwei Xing Department of Physiology, College Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang, PR China These authors contributed equally to this work Correspondence to: Xing, email: xingmingwei@nefu.edu.cn Hou, houzhijundz@hotmail.com Keywords: arsenic, apoptosis, oxidative stress, inflammation, chicken Received: February 01, 2017 Accepted: March 29, Published: April 08,...
Chemotherapy is an important therapeutic approach for non-small cell lung cancer (NSCLC). However, a successful long-term treatment can be prevented by the occurring of chemotherapy resistance frequently, and molecular mechanisms in NSCLC remain unclear. In this study, abnormal expressions miR-17 miR-92 families are observed cisplatin-resistant cells, suggesting that involved regulation cisplatin NSCLC. miRNA microarray shows all down-regulated A549/DDP cells compared with...
Background: Although a number of serum biomarkers for detection hepatocellular carcinoma (HCC) have been explored, their exact diagnostic value remains unclear. We aimed to conduct direct comparison five representative detecting HCC and derive multi-marker prediction algorithms. Patients methods: In total, 846 patients were recruited from three hospitals in China, including 202 patients, 226 liver cirrhosis 215 chronic hepatitis B virus-infected 203 healthy volunteers. Serum levels...
Development of alternative linear peptides for targeting αvβ3 integrin has attracted much attention, as the traditional peptide ligand, cyclic RGD, is limited by inferior water-solubility and complex synthesis.Using pharmacophore-based virtual screening high-throughput molecular docking, we identified two novel small RWr RWrNM with high affinity specificity to integrin.The competitive binding RGD (c(RGDyK)) cellular uptake related expression levels verified their intermolecular interaction...
Environmental mercury is a concern for coastal ecosystem health, and exerts adverse effects on human health. Despite the growing body of evidence showing hepatoprotective roles curcumin mercury, knowledge between macroscopic descriptions actual mechanism(s) underlying these processes getting larger remains elusive. Herein, mice received single injection mercuric chloride (HgCl2) (5 mg/kg weight) and/or (50 mg/kg, weight, p.o.). Firstly, results showed could decline HgCl2-induced up-regulated...
Tumor spread through air spaces (STAS) is a unique mechanism of lung cancer metastasis; however, its clinical value for stage I adenocarcinoma (ADC) remains unclear at present. We investigated the (1) prognosis patients after sublobar resection compared with lobectomy STAS; and (2) potential benefits adjuvant chemotherapy (ACT) ADC STAS.A total 3328 consecutive were retrospectively identified between 2014 2018 our institution; among them, 600 diagnosed STAS. Kaplan-Meier analysis Cox...
Summary We conducted an infrared thermal imaging‐based genetic screen to identify Arabidopsis mutants displaying aberrant stomatal behavior in response elevated concentrations of CO 2 . This approach resulted the isolation a novel allele BIG locus ( At3g02260 ) that we have called insensitive 1 cis1 ). are compromised ‐induced closure and bicarbonate activation S‐type anion channel currents. In contrast with wild‐type, they fail exhibit reductions density index when grown However, like...
Abstract The molecular link between amyloid-β plaques and neurofibrillary tangles, the two pathological hallmarks of Alzheimer’s disease, is still unclear. Increasing evidence suggests that peptide activates multiple regulators cell cycle pathways, including transcription factors CDKs E2F1, leading to hyperphosphorylation tau protein. However, exact pathways downstream amyloid-β-induced imbalance are unknown. Here, we show PAX6, a factor essential for eye brain development which quiescent in...
Polybrominated diphenyl ethers (PBDE-47), a kind of lipophilic persistent organic pollutants (POPs) brominated flame retardant, has been widely used in various consumer products. However, the toxicity PBDE-47 on human immune system not well elucidated. Neutrophil extracellular traps (NETs) contribute to innate responses, and release NETs is recognized as most important part killing mechanism. The aim this study was investigate effect its possible molecular mechanism, intervention curcumin...