A5054248061- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Acupuncture Treatment Research Studies
- Sleep and related disorders
- Health Systems, Economic Evaluations, Quality of Life
- Autophagy in Disease and Therapy
- Medicinal Plants and Bioactive Compounds
- Mitochondrial Function and Pathology
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Pharmaceutical Economics and Policy
- S100 Proteins and Annexins
- Sirtuins and Resveratrol in Medicine
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Anesthesia and Neurotoxicity Research
- Urban Green Space and Health
- Transcranial Magnetic Stimulation Studies
- Complementary and Alternative Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Oral microbiology and periodontitis research
- Urban Heat Island Mitigation
- Health, Environment, Cognitive Aging
Hong Kong Polytechnic University
2016-2025
University of Hong Kong
2006-2022
Chinese University of Hong Kong
2008-2020
Macau University of Science and Technology
2013-2014
Contextual Change (United States)
2012-2014
Institute for Neurodegenerative Disorders
2007-2011
Arizona State University
2002
University of Alabama at Birmingham
1990
Systemic activation of the immune system can exert detrimental effects on central nervous system. Periodontitis, a chronic disease oral cavity, is common source systemic inflammation. Neuroinflammation might be result this to accelerate progressive deterioration neuronal functions during aging or exacerbate pre-existing neurodegenerative diseases, such as Alzheimer's disease. With advancing age, increase in body's pro-inflammatory status favors state vulnerability both periodontitis and In...
Mitochondrial fragmentation due to fission/fusion imbalance has often been linked mitochondrial dysfunction and apoptosis in neurodegeneration. Conventionally, it is believed that once morphology shifts away from its physiological tubular form, mitochondria become defective downstream apoptotic signaling pathways are triggered. However, our study shows beta-amyloid (Aβ) induces morphological changes where they granular-shaped distinct fragmented terms of both functions. Accumulation reactive...
Previous clinical and epidemiological studies have suggested that elevated plasma homocysteine (Hcy) levels increased the risk of Alzheime's disease (AD). Although underlying mechanisms its toxicity are elusive, it has been shown Hcy damages neurons by inducing apoptosis, DNA fragmentation, tau hyperphosphorylation. Wolfberry (Lycium barbarum) is a fruit known for eye-protective anti-aging properties in Asian countries. from our laboratory demonstrated polysaccharides derived wolfberry (LBA)...
Cigarette smoking has been proposed as a major risk factor for aging-related pathological changes and Alzheimer's disease (AD). To date, little is known how can predispose our brains to dementia or cognitive impairment. This study aimed investigate the cigarette smoke-induced in brains. Male Sprague-Dawley (SD) rats were exposed either sham air 4% smoke 1 hour per day 8 weeks ventilated chamber mimic situation of chronic passive smoking. We found that levels oxidative stress significantly...
Accumulation of unfolded proteins can disturb the functions endoplasmic reticulum (ER), leading to ER-stress or protein response (UPR). Recent data have shown that activation UPR be found in postmortem brains Alzheimer's dis
Silica nanoparticles (SiO2-NPs) are naturally enriched and broadly utilized in the manufacturing industry. While previous studies have demonstrated toxicity neuronal cell lines after SiO2-NPs exposure, role of neurodegeneration is largely unknown. Here, we evaluated effects SiO2-NPs-exposure on behavior, neuropathology, synapse young adult mice primary cortical neuron cultures. Male C57BL/6 N (3 months old) were exposed to either vehicle (sterile PBS) or fluorescein isothiocyanate...
The effects of self-administered acupressure (SAA) on knee osteoarthritis (OA) pain remain unclear.
Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective terms of significantly improving Alzheimer patients’ cognition, memory, and execution functions. Nonetheless, there is, currently, no trial evaluating the efficacy TPS on adults with major depression disorder (MDD) nationwide. In this single-blinded, randomized controlled trial, 2-week treatment comprising six 30 min sessions were administered...
Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by regulating macrophage activation, various inflammatory pathways, inflammasome formation. This study aims role PKR in sterile inflammation-triggered cognitive dysfunctions. Here, laparotomy mouse model was used neuroimmune triggered inflammation. Our...
Alzheimer's disease (AD) is an age-related neurodegenerative disease. There are increasing lines of evidence showing that the molecular signaling pathways in aged cells altered so susceptible to injury. We and other laboratories have demonstrated significant involvement double-stranded RNA-dependent protein kinase (PKR) β-amyloid (Aβ) peptide neurotoxicity AD. Fructus lycii (the fruit Lycium barbarum) has long been used oriental medicine as anti-aging agent. Our previous studies aqueous...
Alzheimer's disease and vascular dementia are two major diseases associated with dementia, which is common among the elderly. While etiology of multi-factorial complex, neurodegeneration may be cause these diseases. Effective drugs for treating still to discovered. Current western pharmacological approaches against in develop symptom-relieving disease-modifying drugs. integrative holistic Chinese medicine discovering include (1) single molecules from herbs, (2) standardized extracts a herb,...