A5100340704- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Natural Compound Pharmacology Studies
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Chemical synthesis and alkaloids
- Plant biochemistry and biosynthesis
- Phytochemical compounds biological activities
- Alkaloids: synthesis and pharmacology
- Plant Pathogens and Fungal Diseases
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Organophosphorus compounds synthesis
- 14-3-3 protein interactions
- Microbial Metabolism and Applications
- Traditional Chinese Medicine Analysis
- Catalytic C–H Functionalization Methods
- Traditional and Medicinal Uses of Annonaceae
- Enzyme Catalysis and Immobilization
- Bioactive Natural Diterpenoids Research
Huazhong University of Science and Technology
2016-2025
Culture Resource
2025
Zhengzhou University of Light Industry
2024
Tianjin Medical University
2016-2024
Shanghai University of Sport
2021-2024
Wenzhou Medical University
2023-2024
Chinese PLA General Hospital
2019-2024
Jiangxi Mental Health Center
2024
Tianjin Anding Hospital
2021-2024
Shanghai University of Medicine and Health Sciences
2024
In China, dengue remains an important public health issue with expanded areas and increased incidence recently. Accurate timely forecasts of in China are still lacking. We aimed to use the state-of-the-art machine learning algorithms develop accurate predictive model dengue.Weekly cases, Baidu search queries climate factors (mean temperature, relative humidity rainfall) during 2011-2014 Guangdong were gathered. A index was constructed for developing models combination factors. The observed...
Recent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects on diabetic mice explore underlying mechanisms.The type 2 diabetes were investigated. Increasing doses (25, 50 100 mg·kg(-1) ·day(-1)) administered p.o. db/db for 8 weeks. Biochemical analysis histopathological examinations...
(±)-Hypandrone A (1), a pair of highly modified PPAP enantiomers, with an unprecedented caged 2,8,17-trioxapentacyclo-[11.4.2.0 1,9 .0 4,9 10,15 ]-nonadecane core, were isolated from the fruits Hypericum androsaemum .
Access to quinazolines: The selective amination of C(sp3)H bonds adjacent nitrogen or oxygen atoms N-alkylamides, ethers, alcohols with ortho-carbonyl-substituted anilines constitutes the first step in a tandem annulation that leads quinazolines good excellent yields (see scheme; NIS=N-Iodosuccinimide, TBHP=tert-butyl hydroperoxide). selectivity primary and secondary CH is also noteworthy (left: >3:1, right: >99:1). Detailed facts importance specialist readers are published as "Supporting...
A metal-free sequential dual oxidative amination of C(sp(3))-H bonds under ambient conditions was the first developed, affording imidazo[1,5-a]pyridines in good to excellent yields. The reaction involved two C-N couplings and one dehydrogenation process with six hydrogen atoms removed.
Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures determined on basis of spectroscopic data, a modified Mosher's method, X-ray crystallographic analysis, quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring rearranged bicyclo[3.3.1]nonane motif resulting B-ring scission subsequent 180° rotation ring during biosynthesis. 2 exhibited anti-inflammatory activity.
Abstract Asperchalasine A ( 1 ), the first cytochalasan dimer featuring a unique decacyclic 5/6/11/5/5/6/5/11/6/5 ring system consisting of 20 chiral centers, was isolated from culture broth Aspergillus flavipes . Three biogenetically related intermediates, asperchalasines B–D 2 – 4 were also isolated. Their structures, including their absolute configurations, elucidated using combination HRESIMS, NMR, ECD, molecular modeling, and single‐crystal X‐ray diffraction techniques. Compound , which...
Asperterpenes A and B, two BACE1 inhibitors with unprecedented carbon skeletons isolated from<italic>Aspergillus terreus</italic>, exhibit potent anti-Alzheimer's disease activity.
Enveloped virus particles are released from the membranes of host cells, and viral membrane proteins (M) critical for this process. A better understanding molecular mechanisms SARS-CoV-2 assembly budding is development antiviral therapies.
Tumor necrosis factor-α (TNF-α) is a promising target for inflammatory and autoimmune diseases. Spirohypertones A (1) B (2), two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skeletons, were isolated from Hypericum patulum. The structures of 1 2 confirmed through comprehensive spectroscopic analysis, single-crystal X-ray diffraction electronic circular dichroism calculations. Importantly, showed remarkable TNF-α inhibitory activity, which could protect...
Hyperisampsins A–D (1–4), with tetracyclo[6.3.1.13,10.03,7]tridecane skeletons and seven biogenetically related congeners (5–11), were isolated from Hypericum sampsonii. Their structures elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established ECD calculations, those 5 9 confirmed single X-ray crystallographic analyses. A D showed potent anti-HIV activities EC50 2.97 0.97 μM selectivity index 4.80 7.70, respectively.
Abstract Coumarin derivatives are an important class of C 6 –C 3 plant metabolites that show a variety bioactivities. Currently, most clinical anticoagulant agents coumarins, such as warfarin, dicoumarol and acenocoumarol patients taking these drugs must be monitored for adverse reactions. In search safe effective compounds from Chinese herbal medicine, screening procedure on the whole Ainsliaea fragrans was performed. The phytochemical investigation this afforded five new coumarin...
Abstract Two bioactive merocytochalasans, epicochalasines A ( 1 ) and B 2 ), a new class of cytochalasans bearing unexpected scaffolds consisting fused aspochalasin epicoccine dimer moieties, were isolated from the liquid culture broth Aspergillus flavipes . Both possess hendecacyclic 5/6/11/5/6/5/6/5/6/6/5 ring system containing an adamantyl cage as many 19 stereogenic centers; however, fusion patterns differ greatly, thus resulting in different carbon skeletons. The absolute configurations...
Seven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7), N-ethoxycarbonylpropylcrinasiadine (8), N-phenethylcrinasiadine (9), and N-isopentylcrinasiadine (10), together with eight known hemeanthamin (2), 3-epimacronine (3), (+)-tazettine (4), N-methylcrinasiadine (11), trisphaeridine (12), 5,6-dihydrobicolorine (13), lycorine (14), nigragillin (15), were isolated from the whole plants of...
Dengue cases have been reported each year for the past 25 years in Guangdong Province, China with a recorded historical peak 2014. This study aims to describe epidemiological characteristics of this large outbreak order better understand its epidemic factors and inform control strategies.Data clinically diagnosed laboratory-confirmed dengue fever 2014 were extracted from Notifiable Infectious Disease Reporting System. We analyzed incidence imported indigenous terms population, temporal...
Abstract Asperflavipines A ( 1 ) and B 2 ), two structurally complex merocytochalasans, were isolated from Aspergillus flavipes . Asperflavipine which contains cytochalasan moieties epicoccine moieties, is the first heterotetramer to be discovered. It uniquely defined by 5/6/11/5/6/5/6/5/6/5/5/11/6/5 fused tetradecacyclic rings with three continuous bridged ring systems. a heterotrimer containing 5/6/11/5/5/6/5/6/5 nonacyclic system. The hypothetical biosynthesis of proposed involve...
Bioassay-guided isolation of cultures Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] carbocyclic skeleton, and new biointermediate, andiconin B (2). Their structures absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization oxacillin against...