A5058531504- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microbial Natural Products and Biosynthesis
- Natural Compound Pharmacology Studies
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Synthesis of Organic Compounds
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Crystallography and molecular interactions
- Chemical synthesis and alkaloids
- Bioactive natural compounds
- Cancer, Hypoxia, and Metabolism
- Seaweed-derived Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Alkaloids: synthesis and pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Plant biochemistry and biosynthesis
- Catalytic Alkyne Reactions
- Medicinal Plants and Neuroprotection
- Essential Oils and Antimicrobial Activity
- Eicosanoids and Hypertension Pharmacology
Huazhong University of Science and Technology
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Tongji Hospital
2015-2025
China National Center for Biotechnology Development
2025
Ministry of Education of the People's Republic of China
2023-2024
Saudi Center for Organ Transplantation
2023-2024
Hubei Cancer Hospital
2021
Tianjin Synthetic Material Research Institute (China)
2015
Asperterpenes A and B, two BACE1 inhibitors with unprecedented carbon skeletons isolated from<italic>Aspergillus terreus</italic>, exhibit potent anti-Alzheimer's disease activity.
Tumor necrosis factor-α (TNF-α) is a promising target for inflammatory and autoimmune diseases. Spirohypertones A (1) B (2), two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skeletons, were isolated from Hypericum patulum. The structures of 1 2 confirmed through comprehensive spectroscopic analysis, single-crystal X-ray diffraction electronic circular dichroism calculations. Importantly, showed remarkable TNF-α inhibitory activity, which could protect...
Abstract Extracellular regulated protein kinases (ERK) signaling is a master regulator of cell behavior, life, and fate. Although ERK pathway shown to be involved in T‐cell activation, little known about its role the development allograft rejection. Here, it reported that activated allograft‐infiltrating T cells. On basis surface plasmon resonance technology, lycorine identified as an ERK‐specific inhibitor. inhibition by significantly prolongs survival stringent mouse cardiac allotransplant...
Three pairs of new 8-O-4′-type dinorneolignan enantiomers, (±)-acortatarinowins A–C (1a/1b–3a/3b), a pair (4a/4b) and rare C7–C8′-type (5a/5b) neolignan D E, furofuran-type lignan (±)-acortatarinowin F (6a/6b), along with two known enantiomers (7a/7b 8a/8b), were obtained from the rhizomes Acorus tatarinowii. The separation 1–8 by chiral HPLC using Daicel IC column led to isolation eight 1a/1b–8a/8b, which had variable enantiomeric excess (ee) values approximately 66, 71, 63, 60, 0, 38, 48,...
Asperversiamides A–H (1–8), eight linearly fused prenylated indole alkaloids featuring an unusual pyrano[3,2-f]indole unit, were isolated from the marine-derived fungus Aspergillus versicolor. The structures and absolute configurations of these compounds elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations, optical rotation (OR) calculations. relative configuration C-21 iso-notoamide B was herein revised, a new...
Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) rely an unconventional pathway catalyzed by aspartate transaminase 1 (GOT1) rewire metabolism and support nicotinamide adenine dinucleotide phosphate (NADPH) production. Thus, the important role of GOT1 in energy Reactive Oxygen Species (ROS) balance demonstrates that targeting may serve as therapeutic...
Chemical investigation of the coral-derived fungus Aspergillus terreus led to discovery ten butenolide derivatives (1-10), including four new ones (1-4). The structures were characterized on basis comprehensive spectroscopic analysis, 1D and 2D NMR HRESIMS data. Compounds 1 2 a pair rare C-8'' epimers with vicinal diol motifs. absolute configurations 1-4 determined via [Mo2(AcO)4] induced circular dichroism (ICD) spectra comparison their experimental ECD spectra. Importantly, reported...
Seven undescribed terpestacin-type sesterterpenoids, maydistacins A–G (1–7), along with two known congeners (8 and 9), were isolated from the phytopathogenic fungus Bipolaris maydis collected leaves of Hypericum longistylum. The structures 1–7 elucidated based on extensive spectroscopic analysis, chemical methods, NMR calculations DP4+ probability comparison experimental calculated electronic circular dichroism (ECD) calculations. In vitro anti-inflammatory effects these compounds tested in...
Chemical investigation of <italic>Aspergillus terreus</italic> resulted in the identification terreusterpenes A–D with potential BACE1 and AchE inhibitory activities.
Ten PPAPs with unusual skeletons were isolated from H. perforatum . 6 represents the first multitargeted natural product that could activate PP2A and simultaneously inhibit BACE1, which highlights as a promising lead compound in AD drug development.
Abstract Chronic kidney disease (CKD) is a that affects more than 850 million people. Acute injury (AKI) common cause of CKD, and blocking the AKI–CKD transition shows promising therapeutic potential. Herein, we found butyrolactone I (BLI), natural product, exerts significant nephroprotective effects, including maintenance function, inhibition inflammatory response, prevention fibrosis, in both folic acid‐ ureteral obstruction‐induced mouse models. Notably, BLI showed greater blood urea...
Abstract African swine fever (ASF), caused by virus (ASFV), has resulted in significant economic impacts on the global industry. Currently, there is no safe and effective commercial vaccine available for ASFV. Thus, development of readily therapeutics ASF urgently needed. To conduct high-throughput screening (HTS) anti-ASFV drugs, we initially developed a recombinant dual-reporter (rASFV-Gluc/EGFP) using virulent strain ASFV HLJ/18 (ASFV-WT). The enhanced green fluorescent protein (EGFP)-...
Abstract Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C−G ( 1 – 5 ), along with two known ETPs, prenylemestrin A 6 ) and B 7 were obtained from Aspergillus nidulans . Their structures characterized by spectroscopic data, X-ray crystallographic ECD comparisons calculations. Prenylemestrins − represent a rare class of 2,5-dithia-7,9-diazabicyclo[4.2.2]decane-8,10-dione core involving hemiterpene moiety. Notably, compound exhibited moderate cytotoxicity, inducing...
The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2-8). Their structures were identified by spectroscopic techniques single crystal diffraction experiment. Structurally, (1) was lupane with 28-nor-skeleton. More importantly, 3-5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) concanavalin (ConA) stimulated murine splenocytes proliferation, IC50...
Sixteen 3,5-dimethylorsellinic acid–based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D–M (1–10), were obtained from Aspergillus terreus. The structures and absolute configurations of the compounds confirmed by extensive spectroscopy, single-crystal X-ray diffraction analysis, experimental electronic circular dichroism (ECD) measurements. Compounds 2, 3, 7 are first acid-based meroterpenoids possessing a unique cis-fused A/B ring system. These evaluated for their...
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures absolute configurations confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, electronic circular dichroism (ECD) calculation. All compounds tested for their acetylcholinesterase enzyme (AChE) inhibitory...