A5002698686- Microbial Natural Products and Biosynthesis
- Methane Hydrates and Related Phenomena
- Plant biochemistry and biosynthesis
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Analytical Chemistry and Sensors
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Geology and Paleoclimatology Research
- Ocean Acidification Effects and Responses
- Geological and Geophysical Studies
- Dental Implant Techniques and Outcomes
- Algal biology and biofuel production
- Periodontal Regeneration and Treatments
- Geochemistry and Geologic Mapping
- Marine and coastal ecosystems
- Gas Sensing Nanomaterials and Sensors
- Cancer, Hypoxia, and Metabolism
- Blood disorders and treatments
- Hydrocarbon exploration and reservoir analysis
- Dental Radiography and Imaging
- Microbial Metabolism and Applications
- Marine Biology and Ecology Research
- Advanced Chemical Sensor Technologies
- Antioxidant Activity and Oxidative Stress
Tongji University
2006-2025
Shanghai Stomatological Hospital
2022-2025
Huazhong University of Science and Technology
2006-2025
Huazhong Agricultural University
2024
Zhejiang University
2012-2023
Zhejiang Ocean University
2014-2023
Peking University
2011-2023
Tea Research Institute
2020-2022
Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung
2021
Guangxi University
2021
Abstract Drought and heat are major abiotic stresses frequently coinciding to threaten rice production. Despite hundreds of stress-related genes being identified, only a few have been confirmed confer resistance multiple in crops. Here we report ONAC023, hub stress regulator that integrates the regulations both drought tolerance rice. ONAC023 positively regulates at seedling reproductive stages. Notably, functioning is obliterated without treatment can be triggered by two layers. The...
Molecular signaling in the tumor microenvironment (TME) is complex, and crosstalk among various cell compartments supporting metastasis remains poorly understood. In particular, role of vascular pericytes, a critical cellular component TME, cancer invasion warrants further investigation. Here, we report that an elevation FGF-2 samples from patients with nasopharyngeal carcinoma (NPC) xenograft mouse models promoted NPC metastasis. Mechanistically, cell-derived strongly pericyte proliferation...
Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated more neutropenic phenotypes, we hypothesized an association between genotype SCN development periodontitis.Fourteen Swedish patients or cyclic harboring different genetic backgrounds were recruited for periodontal examination. Peripheral blood, gingival crevicular fluid...
The marine thraustochytrids are a promising source of docosahexaenoic acid (DHA) and the ketocarotenoid astaxanthin. In this study, biosynthetic pathways these two important metabolites in Aurantiochytrium sp. SK4 was illustrated by analyses genome, transcriptome, key enzymes, pathway products. Two sets genes were involved for biosynthesis fatty acids. absence Δ-15 desaturase presence docosapentaenoic (DPA), up to 12% total acids suggest that may synthesize DHA mainly via polyketide synthase...
The paraherquamides are potent anthelmintic natural products with complex heptacyclic scaffolds. One key feature of these molecules is the spiro-oxindole moiety that lends a strained three-dimensional architecture to structures. flavin monooxygenase PhqK was found catalyze spirocycle formation through two parallel pathways in biosynthesis A and G. Two new (K L) were isolated from ΔphqK strain Penicillium simplicissimum, subsequent enzymatic reactions compounds generated additional...
The role of oral bacteria in the development chemotherapy-related mucositis has not been fully elucidated. This study aimed to investigate bacterial community diversity and dynamics paediatric patients with malignancies relation occurrence mucositis. Patients (n = 37) reference individuals without known systemic disorders 38) were recruited. For patients, samples taken from mucosal surfaces both at time malignancy diagnosis during chemotherapy. If occurred, surface lesions. Oral also...
Chemicals underlying the floral aroma of dry teas needs multi-dimensional investigations. Green, black, and freeze-dried tea samples were produced from five cultivars, only ‘Chunyu2’ ‘Jinguanyin’ had scents. green contained highest content total volatiles (134.75 μg/g) among samples, while black (1908.05 samples. The principal component analysis study showed that characterized by abundant presence certain alcohols with aroma, was discriminated due to high levels alcohols, esters, aldehydes....
Talarolactones A-G (1-7), seven novel α-pyrone adducts with unprecedented scaffolds, together two pairs of monomers [(±)-8 and (±)-9)] were isolated from Talaromyces adpressus. Compounds 1-7 are highly modified dimers a 4,7,7,8-tetrasubstitued 5,6,7,8-tetrahydro-2H-chromen-2-one. 5 6 possessed significant NO production inhibitory effect, IC50 values 2.3 ± 0.1 3.7 0.3 μM, respectively. Plausible biosynthetic pathways proposed supported by the results heterologous expression experiments.
Marginal sea methane seep sediments sustain highly productive chemosynthetic ecosystems and are hotspots of intense biogeochemical cycling. Rich supply stimulates rapid microbial consumption oxygen; these systems thus usually hypoxic to anoxic. This reported evidence for resident nitrogen fixation suggest the presence an anaerobic ammonium-oxidizing (anammox) bacterial community in sediments. To test this hypothesis, we employed detection genes encoding 16S rRNA gene hydrazine dehydrogenase...
Carotenoids are important pigments in photosynthetic organisms where they play essential roles photoreception and photoprotection.
Abstract While halogenated nucleosides are used as common anticancer and antiviral drugs, naturally occurring rare. Adechlorin (ade) is a 2′‐chloro nucleoside natural product first identified from Actinomadura sp. ATCC 39365. However, the installation of chlorine in ade biosynthetic pathway remains elusive. Reported herein Fe 2+ ‐α‐ketoglutarate halogenase AdeV that can install atom at C2′ position 2′‐deoxyadenosine monophosphate to afford 2′‐chloro‐2′‐deoxyadenosine monophosphate....
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, dihydroartemisinin (DHA) could synergistically enhance antitumor effect radiotherapy NSCLC. A total 48 patients with sufficient tissues for further analyses enrolled. The evaluated by immunohistochemistry. Cell apoptosis was measured flow cytometry, relationship between expression investigated...
Accumulation of secondary metabolites in the young shoots tea plants is developmentally modulated, especially flavonoids. Here, we investigate developmental regulation mechanism metabolism developing leaves using an integrated multiomic approach. For pair Leaf2/Bud, correlation coefficient fold change mRNA and RPFs abundances involved flavonoid biosynthesis was 0.9359, being higher than that protein (R2 = 0.6941). These correlations were corresponding coefficients for metabolisms genome-wide...
High blood glucose has long been established as a risk factor for tumor metastasis, yet the molecular mechanisms underlying this association have not elucidated. Here we describe that hyperglycemia promotes metastasis via increased platelet activity. Administration of glucose, but fructose, reprogrammed metabolism megakaryocytes to indirectly prime platelets into prometastatic phenotype with adherence cells. In megakaryocytes, metabolism-related gene array identified mitochondrial chaperone...
Renal osteodystrophy is commonly seen in patients with chronic kidney disease (CKD) due to disrupted mineral homeostasis. Given the impaired renal function these patients, common anti-resorptive agents, including bisphosphonates, must be used caution or even contraindicated. Therefore, an alternative therapy without burden combat urgently needed. Here, we report that clinically relevant aerobic exercise significantly prevents high-turnover CKD mouse and compromising function....
Abstract Biosynthetic gene clusters (BGCs), key in synthesizing microbial secondary metabolites, are mostly hidden genomes and metagenomes. To unearth this vast potential, we present BGC-Prophet, a transformer-based language model for BGC prediction classification. Leveraging the transformer encoder, BGC-Prophet captures location-dependent relationships between genes. As one of pioneering ultrahigh-throughput tools, significantly surpasses existing methods efficiency fidelity, enabling...
The continental shelf and slope in the northern South China Sea is well known for its prospect of oil/gas/gas-hydrate resources. To study microbial communities their roles carbon cycling, a 4.9-m sediment core was collected from Qiongdongnan Basin on during our cruise HY4-2005-5 2005. Geochemical, mineralogical, molecular phylogenetic analyses were carried out. Sulfate concentration pore water decreased with depth. Abundant authigenic carbonates pyrite observed sediments. bacterial community...
This prospective study evaluated clinical risk indicators as well pro- and anti- inflammatory mediators at the time of malignancy diagnosis in relation to chemotherapy-related oral mucositis pediatric population.Patients (n = 104) under 18 years age with primary malignancies undergoing chemotherapy were included. Potential analyzed using binary logistic regression outcome. In a subgroup 35), plasma samples for cytokines an antimicrobial protein pro-LL-37 (hCAP18).In multivariable model, type...
A naturally new cyclopeptide, clavatustide C, was produced as a stress metabolite in response to abiotic elicitation by one of the hydrothermal vent fluid components Zn cultured mycelia Aspergillus clavatus C2WU, which were isolated from Xenograpsus testudinatus. X. testudinatus lives at extreme, toxic habitat around sulphur-rich vents Taiwan Kueishantao. The known compound B also and purified. This is first example microbial secondary treatment. structures established spectroscopic means....