A5040085770- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Oral and gingival health research
- Rheumatoid Arthritis Research and Therapies
- Obstructive Sleep Apnea Research
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Salivary Gland Disorders and Functions
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Dental Health and Care Utilization
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS oral health manifestations
- Inflammasome and immune disorders
- Probiotics and Fermented Foods
- Immune Response and Inflammation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dental Implant Techniques and Outcomes
- Drug-Induced Adverse Reactions
- Endodontics and Root Canal Treatments
- Neuroscience of respiration and sleep
- Systemic Lupus Erythematosus Research
Karolinska Institutet
2016-2025
Jagiellonian University
2024-2025
University of Copenhagen
2020
Malmö University
2020
Bergen Kommune
2020
University of Bergen
2020
Karolinska University Hospital
2010
Umeå University
2003-2004
Public Dental Service Västra Götaland
2004
Lund University
1999
To investigate the effect of a chewing gum containing probiotic bacteria on gingival inflammation and levels selected inflammatory mediators in crevicular fluid (GCF).Forty-two healthy adults with moderate entered double-blind placebo-controlled study design. The subjects were randomly assigned to one three parallel arms: Group A/P was given active placebo daily, A/A received two gums, P/P gums. gums contained strains Lactobacillus reuteri: ATCC 55730 PTA 5289 (1 x 10(8) CFU/gum,...
To investigate the role of periodontal pathogen Porphyromonas gingivalis in etiology rheumatoid arthritis (RA) by analyzing antibody response to P virulence factor arginine gingipain type B (RgpB) relation anti-citrullinated protein antibodies (ACPAs), smoking, and HLA-DRB1 shared epitope (SE) alleles patients with periodontitis, RA, controls.
Periodontitis is a microbial-induced chronic inflammatory disease, which may not only result in tooth loss, but can also contribute to the development of various systemic diseases. The transition from healthy diseased periodontium depends on microbial dysbiosis and impaired host immune response. Although periodontitis common disease as well associated with conditions, taxonomic profiling salivary microbiota its association mediators has been reported. Therefore, aim this study was identify...
Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown. Treponema denticola (Td) is associated with severe periodontitis, a chronic inflammatory disease leading tooth loss. The anaerobic spirochete Td an invasive bacteria due its major virulence factor chymotrypsin-like proteinase. Here we aimed investigate presence of proteinase (Td-CTLP) in orodigestive tumours elucidate potential for contribute...
This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation oral microbiota, systemic and inflammatory mediators, RA disease activity. Forty underwent full-mouth dental/periodontal rheumatological examination, including collection blood, saliva, gingival crevicular fluid (GCF) subgingival plaque. Composition plaque saliva microbiota were analysed using 16S rRNA sequencing levels mediators by multiplex-immunoassay. The majority...
Probiotic bacteria have been introduced for prevention and treatment of periodontal diseases. The aim was to assess if daily oral administration probiotic could influence the inflammatory response composition supragingival plaque in an experimental gingivitis model.Eighteen healthy female adults volunteered after informed consent. A double-blind randomized placebo-controlled cross-over design used. buccal surface first molars used as sites. mouth-guard covering premolar second molar when...
Introduction The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence in Swedish Epidemiological Investigation RA (EIRA), well-characterised population-based case-control cohort. Methods Periodontal status 2,740 cases 3,942 matched controls was retrieved through linking EIRA with National Dental Health Registry (DHR), where dental diagnostic- treatment...
A relationship between rheumatoid arthritis (RA) and periodontitis has been suggested from findings that individuals with RA are prone to have advanced vice versa. In search of possible common pathogenetic features these two diseases, we investigated the presence citrullinated proteins expression endogenous peptidylarginine deiminases (PAD2 PAD4), in periodontal tissue healthy controls, relation pathogens Porphyromonas gingivalis (P. gingivalis) Aggregatibacter actinomycetemcomitans (A....
Abstract Periodontitis is a highly prevalent chronic inflammatory disease of the periodontium, leading ultimately to tooth loss. In order characterize gene expression periodontitis-affected gingival tissue, we have here simultaneously quantified and localized in periodontal tissue using spatial transcriptomics, combining RNA sequencing with histological analysis. Our analyses revealed distinct clusters expression, which were identified correspond epithelium, inflamed areas connective...
Abstract Sequencing the nucleic acid content of individual cells or specific biological samples is becoming increasingly common. This drives need for robust, scalable and automated library preparation protocols. Furthermore, an increased understanding tissue heterogeneity has lead to development several unique sequencing protocols that aim retain infer spatial context. In this study, a protocol retaining information transcripts been adapted run on robotic workstation. The method...
Objectives Periodontitis and rheumatoid arthritis (RA) are two widespread chronic inflammatory diseases with a previously suggested association. The objective of the current study was to compare oral microbial composition host´s mediator profile saliva samples obtained from subjects periodontitis, without RA, as well predict biomarkers, bacterial pathogens and/or mediators, for classification associated periodontitis RA. Methods Salivary were 53 patients RA 48 non-RA periodontitis....
ABSTRACT Objective This cross‐sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri‐implant disease as compared health. Materials Methods Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising health ( N = 41), gingivitis and/or mucositis 18), periodontitis peri‐implantitis 96). Samples analyzed using multiplex‐immunoassay panel consisting tumor necrosis factor (TNF), interferon...
The aim of this study was to investigate the relationship between body mass index (BMI kg/m[Formula: See Text]), inflammatory mediator tumor necrosis factor α (TNFα), and interleukin-8 (IL-8) in gingival crevicular fluid (GCF) from 32 obese subjects aged 13 24 years. Gingival inflammation (GBI %), pathological pocket depths, alveolar bone loss diagnosed on radiographs were recorded. GCF collected six sites per subject using periopaper, volume determined Peritron 8000. levels TNFα IL-8 ELISA...
Periodontitis is associated with enhanced production of cytokines, prostaglandins and matrix metalloproteinases (MMPs). The aim this study was to investigate the regulation MMP-1 MMP-3 in human gingival fibroblasts challenged cytokines interleukin-lbeta (IL-1beta), tumor necrosis factor alpha (TNFalpha) or epidermal growth (EGF). results showed that constitutively produce MMP-3, IL-1beta, TNFalpha EGF increase both fibroblasts. upregulation by apparent at 8 h incubation increased thereafter...
In a cross-sectional study design we test the hypothesis of whether obesity in adolescence is associated with periodontal risk indicators or disease.Obese adolescents (n=52) and normal weight subjects mean age 14.5 years were clinically examined respect to dental plaque, gingival inflammation, pockets incipient alveolar bone loss. The answered questionnaire concerning medical conditions, oral hygiene habits, smoking habits sociodemographic background. Body mass index (BMI) was calculated...
Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated more neutropenic phenotypes, we hypothesized an association between genotype SCN development periodontitis.Fourteen Swedish patients or cyclic harboring different genetic backgrounds were recruited for periodontal examination. Peripheral blood, gingival crevicular fluid...
Abstract The multifactorial chronic inflammatory disease periodontitis, which is characterized by destruction of tooth-supporting tissues, has also been implicated as a risk factor for various systemic diseases. Although periodontitis studied extensively, neither disease-specific biomarkers nor therapeutic targets have identified, its link with Here, we analyzed the global transcriptome and compared gene expression profile those other conditions, including cardiovascular (CVD), rheumatoid...
A key element for long-term success of dental implants is integration the implant surface with surrounding host tissues. Modification titanium surfaces can enhance osteoblast activity but their effects on soft-tissue cells are unclear. Adherence human keratinocytes and gingival fibroblasts to control commercially pure (CpTi) two prepared by anodic oxidation was therefore investigated. Since abutments exposed a bacteria-rich environment in vivo, effect oral bacteria keratinocyte adhesion also...
Obstructive sleep apnea (OSA) and enhanced vascular inflammation coexist in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is first-line treatment for OSA daytime sleepiness. This analysis of data from the RICCADSA (Randomized Intervention CPAP Coronary Artery Disease Sleep Apnea) trial investigated effects on inflammatory markers CAD nonsleepy OSA. single-center, randomized, controlled, open-label enrolled consecutive revascularized (apnea–hypopnea...
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), unique feature of periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production anti-citrullinated protein antibodies (ACPA), which are present in a majority RA patients, may be triggered gum mucosa. To address this hypothesis, we investigated antibody response citrullinated P. peptide relation autoimmune ACPA early RA, examined citrulline-reactivity...
Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting teeth. We have previously shown that tumor necrosis factor α (TNFα) induces PGE2 synthesis fibroblasts. In this study we aimed to investigate global gene expression profile TNFα-stimulated primary human fibroblasts, focusing on signal pathways related PGE2-synthesizing enzymes prostaglandin E synthases (PGES), as well...