A5102667729- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Natural Compound Pharmacology Studies
- Plant and fungal interactions
- Microbial Metabolism and Applications
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Chemical synthesis and alkaloids
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis of Organic Compounds
- Enzyme Catalysis and Immobilization
- Pharmacogenetics and Drug Metabolism
- Natural product bioactivities and synthesis
- Synthetic Organic Chemistry Methods
- Plant Pathogens and Fungal Diseases
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Chaos-based Image/Signal Encryption
- Biochemical and Molecular Research
- Advanced Synthetic Organic Chemistry
- Veterinary medicine and infectious diseases
- Catalytic C–H Functionalization Methods
- Glycosylation and Glycoproteins Research
- Phytochemistry and Biological Activities
Shanghai Jiao Tong University
2023-2024
Wuhan University
2024
Institute of Microbiology
2019-2022
Chinese Academy of Sciences
2019-2022
Microbiology Institute of Shaanxi
2019-2022
University of Chinese Academy of Sciences
2019-2022
Huazhong University of Science and Technology
2015-2017
Beijing Electronic Science and Technology Institute
2015
Abstract Asperflavipines A ( 1 ) and B 2 ), two structurally complex merocytochalasans, were isolated from Aspergillus flavipes . Asperflavipine which contains cytochalasan moieties epicoccine moieties, is the first heterotetramer to be discovered. It uniquely defined by 5/6/11/5/6/5/6/5/6/5/5/11/6/5 fused tetradecacyclic rings with three continuous bridged ring systems. a heterotrimer containing 5/6/11/5/5/6/5/6/5 nonacyclic system. The hypothetical biosynthesis of proposed involve...
Aspergilasines A–D (1–4), four merocytochalasans with new skeletons, were isolated from the liquid culture broth of Aspergillus flavipes QCS12. Aspergilasine A (1) possesses a uniquely caged pentacyclo[7.2.0.14,11.02,7.05,10]dodecane skeleton an unexpected cyclobutane ring that formed by fusion two epicoccine moieties via [3 + 2] cycloadditions. B–D (2–4) are key biosynthetic intermediates epicochalasine B fit well our previous proposal.
Since imine reductases (IREDs) were reported to catalyze the reductive amination reactions, they became particularly attractive for producing chiral amines. Though diverse ketones and aldehydes have been proved be excellent substrates of IREDs, bulky amines rarely transformed. Here we report usage an Increasing-Molecule-Volume-Screening identify a group IREDs (IR-G02, 21, 35) competent accepting amine substrates. IR-G02 shows substrate scope, which is applied synthesize over 135 molecules as...
Abstract Two new tetracyclic cytochalasans, flavichalasines A and B ( 1 2 ), three pentacyclic C–E 3 – 5 eight tricyclic F–M 6 13 together with known analogues 14 21 were isolated from the solid culture of Aspergillus flavipes . Structures these compounds elucidated on basis extensive spectroscopic analyses including 1D, 2D NMR HRESIMS data. Their absolute configurations determined by comparison their experimental ECD either computed or spectrum compound. The structure configuration further...
A dedicated enzyme for the formation of central C ring in tetracyclic ergoline clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O2 as oxidant, that catalyzes oxidative cyclization from 1,3-diene intermediate. Our study showcases how nature evolves common enantioselective C–C bond construction complex polycyclic scaffolds.
Two new azaphilone derivatives, chaephilones A (1) and B (2), were isolated from the fungus Chaetomium globosum, together with four structurally related analogs 3 - 6. The structures of 1 2 elucidated by comprehensive spectroscopic analyses including HR-ESI-MS NMR. known compounds identified as chaetomugilin Q (3), D (4), 11-epichaetomugilin (5), S (6) comparing their NMR data optical rotation values those reported. Compound represents first example an open furan ring. Compounds evaluated...
Abstract A highly oxygenated hexacyclic indole alkaloid, penicamedine ( 1 ), bearing a rare furan ring, was isolated from the culture broth of Penicillium camemberti , together with two known analogs, iso‐ α ‐cyclopiazonic acid 2 ) and cyclopiazonic 3 ). The structure elucidated by comprehensive spectroscopic analyses including NMR HR‐ESI‐MS. Its absolute configuration further confirmed unambiguously single‐crystal X‐ray diffraction analysis. Compound evaluated for anti‐HIV activity p24...
Seven prenylated benzoylphloroglucinol derivatives, named sampbenzophenones A–G (<bold>1–7</bold>), together with two known analogues (<bold>8</bold> and <bold>9</bold>), were isolated from the aerial parts of <italic>Hypericum sampsonii</italic>.
Abstract Asperflavipines A ( 1 ) and B 2 ), two structurally complex merocytochalasans, were isolated from Aspergillus flavipes . Asperflavipine which contains cytochalasan moieties epicoccine moieties, is the first heterotetramer to be discovered. It uniquely defined by 5/6/11/5/6/5/6/5/6/5/5/11/6/5 fused tetradecacyclic rings with three continuous bridged ring systems. a heterotrimer containing 5/6/11/5/5/6/5/6/5 nonacyclic system. The hypothetical biosynthesis of proposed involve...
A cryptic tetronate biosynthetic pathway was identified in Kitasatospora niigatensis DSM 44781 via heterologous expression. Distinct from the currently known pathways, this system utilizes a partially functional nonribosomal peptide synthetase and broadly selective polyketide synthase to direct assembly lactonization of scaffold. By employing permissive crotonyl-CoA reductase/carboxylase provide different extender units, seven new tetronates (kitaniitetronins A–G) were obtained...
P450 peroxidase activities are valued for their ability to catalyze complex chemical transformations using economical H 2 O ; however, they have been largely underexplored compared monooxygenase and peroxygenase activities. In this study, we identified an unconventional enzyme, PtmB, which catalyzes the dimerization of purine nucleobases tryptophan-containing diketopiperazines (TDKPs), yielding C3-nucleobase pyrroloindolines nucleobase-TDKP dimers. Unlike typical TDKP enzymes reliant on...
With the rapid development of network, more and digital images need to be stored communicated. Due openness network sharing, problems image security become an important threat In this paper, we propose a novel gray encryption algorithm based on chaotic mapping DNA (Deoxyribonucleic Acid) encoding. We solve error irreversibility previous work, which can only encrypt plain image, cannot decrypt cipher with correct secret key attacked by chosen plaintext. To make invertible, encode input...
Heterologous expression of the flavipucine biosynthetic gene cluster in Aspergillus nidulans led to production (1) and dihydroisoflavipucine (3), as well six unusual related products containing three classes heterocycles. This combined with inactivation, chemical complementation, transcriptome analysis demonstrated unprecedented ways form 2-pyridone 2-pyrone structures by oxidative rearrangements pyrrolinone precursors provided insights into biosynthesis this important class natural products.
The flavoprotein monooxygenase (FPMO) TerC is encoded by all known cyclopentene biosynthetic gene clusters. It can catalyze oxidative dearomatization toward a series of 6-HM analogues and further induces different skeletal distortions to form either benzoquinone or pyrone bimodal reaction cascades, which only governed the C7 substitutions. Beyond our study demonstrated cascades advanced knowledge fungal cyclopentenes, this work also sets stage for bioengineering polyketides.