A5100338277- Viral Infections and Immunology Research
- Parasites and Host Interactions
- Cardiac Fibrosis and Remodeling
- Vitamin K Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Iron Metabolism and Disorders
- Heart Failure Treatment and Management
- RNA modifications and cancer
- Aortic Disease and Treatment Approaches
- Eicosanoids and Hypertension Pharmacology
- RNA Research and Splicing
- Renin-Angiotensin System Studies
- Cardiac Health and Mental Health
- Animal Disease Management and Epidemiology
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Cardiac and Coronary Surgery Techniques
- Animal Virus Infections Studies
- Congenital heart defects research
- Heavy Metal Exposure and Toxicity
- Cardiovascular Health and Risk Factors
Huazhong University of Science and Technology
2017-2025
Tongji Hospital
2019-2025
Huazhong Agricultural University
2025
Anhui University of Traditional Chinese Medicine
2025
Bengbu Medical College
2019-2023
Union Hospital
2023
First People's Hospital of Chongqing
2022
Xijing Hospital
2022
Air Force Medical University
2022
Xiangya Hospital Central South University
2019-2020
Abstract Fulminant myocarditis (FM) is a severe inflammatory condition of the myocardium that often results in sudden death, particularly young individuals. In this study, we employed single-nucleus and spatial transcriptomics to perform comprehensive analysis coxsackievirus B3 (CVB3)-induced FM A/J mice, spanning seven distinct time points pre- post-treatment. Our findings reveal mesothelial cells play critical role early stage by acting as primary targets for CVB3 infection. This triggers...
Fulminant myocarditis (FM) is a life-threatening inflammatory disease. However, the mechanisms underlying its acute onset are unknown. By dynamic cardiac function measurement, we discovered that initiation of sudden hemodynamic collapse was on day 4 in mouse model FM. Single-cell RNA-sequencing study revealed healthy cardiomyocytes (CMs) lost their contractile and metabolic differentiated into pro-angiogenic pro-inflammatory CMs. Meanwhile, neutrophils, most expanded immune cells, exhibited...
Background The aim of the study was to identify biomarkers that can facilitate early diagnosis and treatment fulminant myocarditis (FM) in order reduce mortality. Methods Results First, expression profiles circulating cytokines were determined plasma samples from 4 patients with FM controls using human cytokine arrays. results showed 39 changed at admission. Among them, 8 returned normal levels discharge, including soluble ST2 (sST2), which most marked dynamic changes disease onset...
Helminths immunomodulate the host immune system by secreting proteins to create an inhibitory environment as a strategy for survival in host. As bystander effect, this balances reduce hypersensitivity allergens or autoantigens. Based on this, helminth therapy has been used treat some allergic autoimmune diseases. tissue-dwelling helminth, Trichinella spiralis infection identified have strong immunomodulatory effects; effective components worm not yet identified. The soluble extracts of T....
Purpose: Morbidity associated with and mortality from acute kidney injury (AKI) is gradually increasing, no efficient drug available. We explored whether neferine, a bisbenzylisoquinoline alkaloid, attenuated AKI, the possible mechanisms in play vivo vitro. Methods: induced AKI using ischemia-reperfusion (I/R) or lipopolysaccharide (LPS) vivo. C57 BL/6 male mice were randomized into two groups each containing four subgroups: control, I/R LPS, LPS + neferine. Mice sacrificed 24 h after...
Multi-organ failure caused by the inflammatory cytokine storm induced severe infection is major cause of death for sepsis. Sj-Cys a cysteine protease inhibitor secreted Schistosoma japonicum with strong immunomodulatory functions on host immune system. Our previous studies have shown that treatment recombinant protein (rSj-Cys) attenuated inflammation However, immunological mechanism underlying immunomodulation regulating diseases not yet known. In this study, we investigated effect...
Abstract Background and Purpose Myocarditis is a life‐threatening inflammatory disease, but lacks effective treatment options. Hydroxychloroquine (HCQ), an established antimalarial agent, used widely to manage rheumatic disorders. This research aimed evaluate the efficacy of HCQ in treating myocarditis. Experimental Approach A mouse model experimental autoimmune myocarditis (EAM) was therapeutic effects on cardiac function, inflammation fibrosis. Echocardiography, histology cytokine assays...
Angiotensin-converting enzyme 2 (ACE2), its product angiotensin-(1-7), and receptor Mas have been shown to moderate the adverse effects of ACE-angiotensin II-AT1 axis in many diseases. The aim this study was determine whether ACE2-Ang-(1-7)-Mas could similar a cell culture model pancreatic damage.AR42J cells were stimulated with 10 nmol/L cerulein simulate acute pancreatitis. ACE2, Ang-(1-7), receptor, PI3K/AKT pathway measured by quantitative real-time polymerase chain reaction Western blot...
Abstract Background Myocardial dysfunction is one of the most common complications multiple organ failure in septic shock and significantly increases mortality patients with sepsis. Although many studies having confirmed that helminth-derived proteins have strong immunomodulatory functions could treat inflammatory diseases, there no report on therapeutic effect Schistosoma japonicum -produced cystatin ( Sj- Cys) sepsis-induced cardiac dysfunction. Methods A model myocardial injury was...
Sepsis is a life-threateningorgandysfunction caused by the cytokine storm induced severe bacterial infection. Excessive inflammatory responses are responsible for lethal organ damage during early stage of sepsis. Helminth infection and helminth-derived proteins have been identified to ability immunomodulate host immune system reducing inflammation against diseases. Trichinella spiralis cystatin (Ts-Cys) cysteine protease inhibitor with strong immunomodulatory functions on system. Our...
Background: The loss of iron stores and resulting deficiency is well documented in whole blood or red cell donors. We hypothesized that relative also occurs as a result more frequent platelet‐ plasma‐pheresis (apheresis) donation. Materials Methods: To test this hypothesis, we proposed pilot cross‐sectional study to analyze erythropoiesis‐ iron‐related parameters white male apheresis donors: (1) controls, (2) correlation with donation frequency, (3) pre‐donation platelet count. Results:...
Acute lung injury (ALI) is a common complication of systemic inflammation or sepsis with high morbidity and mortality. Although many studies have confirmed that helminth-derived proteins had strong immunomodulatory functions could be used to treat inflammatory diseases, there no report on the therapeutic effect excretory-secretory products Trichinella spiralis adult worms ( Ts -AES) sepsis-induced ALI. In this study, efficacy -AES ALI underlying immunological mechanism signaling pathway were...
Lung cancer (LC) is one of the leading causes death worldwide, which highlights urgent need for better therapies. Peroxisome proliferator-activated nuclear receptor alpha (PPARα), known as a key transcription factor involved in glucose and lipid metabolism, has been also implicated endothelial proliferation angiogenesis. However, effects potential mechanisms novel PPARα ligand, AVE8134, on LC growth progression remain unclear.A subcutaneous tumour was established mice by injecting TC-1 lung...
Aims Long non-coding RNAs (lncRNAs) are critical regulators of viral infection and inflammatory responses. However, the roles lncRNAs in acute myocarditis (AM), especially fulminant (FM), remain unclear. Methods FM non-fulminant (NFM) were induced by coxsackie B3 virus (CVB3) different mouse strains. Then, expression profiles heart tissues detected sequencing. Finally, patterns analyzed Pearson/Spearman rank correlation, Kyoto Encyclopedia Genes Genomes, Cytoscape 3.7. Results First, 1,216,...
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate inflammatory diseases, immunomodulatory effect recombinant Schistosoma japonicum cystatin (rSj-Cys) on metabolic diseases atherosclerosis has not reported. In this study, we investigated therapeutic efficacy rSj-Cys atherosclerotic renal damage explored related immunological mechanism. The results...
Long noncoding RNAs (lncRNAs) are currently considered to have a vital and wide range of biological functions, but the molecular mechanism underlying triglycerides metabolism remains poorly understood. This study aims identify novel lncRNAs differentially expressed in rat livers with hypertriglyceridemia elucidated function role TG metabolism. Differentially expressions were identified by transcriptome sequencing validated real-time PCR. The lnc19959.2 triglyceride was assessed both vitro...
Fulminant myocarditis (FM) is the severest type of and requires timely diagnosis treatment. However, effective biomarkers for early FM are limited. First, 12 common inflammatory cytokines levels in plasma patients with were measured using human cytokine 12-Plex assay. Then, enzyme-linked immunosorbent assay (ELISA) was used to detect another eight that we previously reported on. Moreover, a Spearman correlation test employed investigate correlations between clinical parameters FM. Finally,...
Chronic heart failure (CHF) has poor prognosis and polygenic heritability, the genetic risk score (GRS) to predict CHF outcome not yet been researched comprehensively. In this study, we sought establish GRS outcomes of CHF. We re-analysed proteomics data failing human combined them filter high-throughput sequencing in 1000 Chinese cohort. Cox hazards models were used based on single nucleotide polymorphisms (SNPs) estimate association with CHF, analyse difference between individual SNPs...
Background: Viral myocarditis could initiate various immune response to the myocardium, resulting in myocyte damage and subsequent cardiac dysfunction. The expression profile functions of circRNAs this process are unknown. Methods: Fulminant (FM) non-FM models were induced by coxsackie B3 virus (CVB3) infection A/J mice C57BL/6 mice, respectively. CircRNAs was identified RNA-seq. Quantitative RT-PCR, Spearman rank correlation, KEGG pathway, GO analysis, Western blot flow cytometry performed...
Endoplasmic reticulum stress (ERS) occurs when misfolded or unfolded proteins accumulate in the endoplasmic (ER), and it is often observed tumors, including head neck squamous cell carcinoma (HNSCC). Relevant studies have demonstrated prognostic significance of ERS-related long non-coding RNAs (lncRNAs) various cancers. However, relationship between ERS lncRNAs HNSCC has received limited attention previous studies. In this study, we aimed to develop an model using correlation analysis, Cox...