A5012507700- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Thermochemical Biomass Conversion Processes
- Liver Disease Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Neuroendocrine regulation and behavior
- Retinal Development and Disorders
- Pancreatic function and diabetes
- CAR-T cell therapy research
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Enzyme-mediated dye degradation
- Congenital heart defects research
- Circadian rhythm and melatonin
- Heart Failure Treatment and Management
- RNA modifications and cancer
- Lung Cancer Research Studies
- Coal Properties and Utilization
- Diabetes and associated disorders
- Connective tissue disorders research
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
China University of Mining and Technology
2012-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2025
Infinitus (China)
2024
Hunan Institute of Microbiology
2024
Nanjing University
2023-2024
University of Shanghai for Science and Technology
2024
Fudan University
2021-2024
Zhongshan Hospital
2021-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from ventral mesencephalon (VM) DAergic neurons increases excitability of VM-projecting D1-dopamine receptor-expressing medium spiny (D1-MSNs) NAc to enhance release augment rewards. However, how such a positive feedback loop regulated maintain homeostasis reward-aversion balance remains elusive. Here we report that pallidum (VP) projection D1-MSNs (D1NAc-VP) inhibited by rewarding...
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Background This study aimed to assess the effects of restricting mobile phone use before bedtime on sleep, pre-sleep arousal, mood, and working memory. Methods Thirty-eight participants were randomized either an intervention group (n = 19), where members instructed avoid using their 30 minutes bedtime, or a control given no such instructions. Sleep habit, sleep quality, arousal mood measured diary, Pittsburgh quality index, Pre-sleep Arousal Scale Positive Negative Affect Schedule...
BackgroundAs aortic aneurysms (AAs) enlarge, they can become life-threatening if left undiagnosed or neglected. At present, there is a lack of radical treatments for preventing disease progression. Therefore, we aimed to identify effective drug targets that slow the progression AAs.MethodsA Mendelian randomization (MR) analysis was conducted therapeutic which are associated with AAs. Summary statistics AAs were obtained from two datasets: UK Biobank (2228 cases and 408,565 controls) FinnGen...
The experience of rewarding or aversive stimuli is encoded by distinct afferents to dopamine (DA) neurons the ventral tegmental area (VTA). Several neuromodulatory systems including oxytocin regulate DA neuron excitability and synaptic transmission that process socially meaningful stimuli. We others have recently characterized oxytocinergic modulation activity in mouse VTA neurons, but mechanisms underlying remain poorly understood. Here, we find application optogenetic release decrease...
Gastric cancer (GC) is among the most lethal human malignancies, and leading cause of GC mortality metastasis. However, precise mechanism metastasis remains unclear. To screen key transcriptional factors (TFs) involved in metastasis, we performed bioinformatics analysis The Cancer Genome Atlas database found that Krüppel-like factor 9 (KLF9) a metastasis-associated TF. KLF9 significantly decreased patients with distant compared those without Ectopic expression evidently inhibited migration...
Hypersomnolence disorder (HD) is characterized by excessive sleep, which a common sequela following stroke, infection, or tumorigenesis. HD traditionally thought to be associated with lesions of wake-promoting nuclei. However, single nucleus, even two simultaneously, did not exert serious HD. Therefore, the specific nucleus and neural circuitry for remain unknown. Here, we observed that paraventricular hypothalamus (PVH) exhibited higher c-fos expression during active period (23:00) than...
Escaping aversive stimuli is essential for complex organisms, but prolonged exposure to stress leads maladaptive learning. Stress alters neuronal activity and neuromodulatory signaling in distributed networks, modifying behavior. Here, we describe changes dopaminergic neuron following learning a learned helplessness paradigm mice. A single dose of ketamine suffices restore escape behavior after Dopaminergic the ventral tegmental area (VTA) systematically varies across learning, correlating...
Oxytocin (OXT) neurons in paraventricular nucleus of hypothalamus (PVN) are involved modulating multiple functions, including social, maternal, feeding, and emotional related behaviors. PVN OXT canonically classified into magnocellular (Magno) parvocellular (Parvo) subtypes. However, morpho-electric properties the diversity not well investigated. In this study, we profiled by combining transgenic mice, electrophysiological recording, morphologic reconstruction, unsupervised clustering...
Hepatocellular carcinoma (HCC) is the fifth most common cancer and third cause of cancer-related deaths, worldwide. It essential to develop an effective prognostic biomarker determine mechanisms underlying HCC invasion metastasis. This study aimed investigate expression Golgi glycoprotein73 (GP73) Epithelial-mesenchymal transition (EMT) molecules such as E-cadherin Vimentin in HCC. We also evaluated value GP73 Immunohistochemistry (IHC) was used EMT 75 specimens corresponding...
Genome-wide association studies (GWAS) have identified abundant risk loci associated with schizophrenia (SCZ), cardiovascular disease and metabolic diseases (including body mass index, type 2 diabetes, low- high-density lipoprotein, total cholesterol triglycerides). Although recent suggested shared genetic between these disorders, the common genes biological pathways them are still vague. Here we integrated comprehensive multi-dimensional data from GWAS, expression quantitative trait (eQTL)...
Background: MicroRNA (abbreviated miRNA)-based treatment holds great promise for application as clinical antitumor therapy, but good carriers delivery of the miRNA drug are lacking. Exosomes secreted by mesenchymal stem cells (MSCs) have proved to be safe, and exogenously modified exosomes may potentially represent an excellent vehicle. Methods: In this study, we designed a nano system using single-stranded variable fragment (scFv)-modified derived from human cord blood MSCs. Genetic...
Abstract Background Phenylacetylglutamine (PAGln)—a newly discovered microbial metabolite produced by phenylalanine metabolism—is reportedly associated with cardiovascular events via adrenergic receptors. Nonetheless, its association outcomes in heart failure (HF) patients remains unknown. Objectives This study aimed to prospectively investigate the prognostic value of PAGln for HF. Methods Plasma levels were quantified liquid chromatography‐tandem mass spectrometry. We first assessed...
Islets damage is a major abnormality underling diabetes. Recent studies suggested the value of exosomes in diagnosis. This study aimed to investigate impact injury factors on miRNA profiles islet and determine whether circulating exosomal miRNAs suitable as biomarkers islets damage. were isolated from ICR mice induced vitro by mixed cytokines (Tumor Necrosis Factor-α, Interleukin -1β Interferon-γ) or streptozotocin (STZ), derived cultural supernatant. Using microarray analysis, we found 22...
Urocortin 2 (Ucn2), a peptide of the corticotropin-releasing factor (CRF) family, binds with high affinity to type CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/reperfusion. The mechanisms by which Ucn2-CRFR2 axis mitigates ischemia/reperfusion injury remain incompletely delineated. Activation AMP-activated protein kinase (AMPK) also limits cardiac damage during AMPK is classically activated alterations in cellular energetics; however, hormones, cytokines,...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...