A5101950113- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Neuroendocrine regulation and behavior
- Thyroid Disorders and Treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- HIV/AIDS Research and Interventions
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gestational Diabetes Research and Management
- Gut microbiota and health
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Hebei Medical University
2014-2025
Beijing Friendship Hospital
2008-2025
Capital Medical University
2008-2025
Hanshan Normal University
2024
Xingtai People's Hospital
2024
Xingtai Medical College
2024
Hebei Chemical and Pharmaceutical College
2021-2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2021
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Objectives Follicular helper T (Tfh) cells exert an important role in autoimmune diseases. Whether it might be involved type 1 diabetes (T1D) is unknown. Our aim was to investigate the of Tfh patients with T1D and effect anti-CD20 monoclonal antibody (rituximab) on from patients. Patients Methods Fifty-four 37 healthy controls were enrolled current study. 20 those treated rituximab. The frequencies circulating CD4+CXCR5+ICOS+T analyzed by flow cytometry. serum autoantibodies detected...
Objective The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the arterial stiffness in order investigate effects of on CVD. Methods We collected data from 5,158 individuals over 40 years age a cross-sectional Nanjing, China. Anthropometric, demographic, hemodynamic measurements measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects grouped by body mass index (BMI), waist circumference (WC) visceral...
Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present was to explore relationship between vitamin status and TSH levels thyroid autoimmunity taken into consideration a population-based health survey middle-aged elderly Methods. total 1,424 Chinese adults, aged 41-78 years, were enrolled this cross-sectional study. Serum 25(OH)D, TSH,...
Recently, the question of whether vitamin D exerts an effect on pathogenic process infertility has become centre attention. There are some controversial conclusions this issue. Based previous studies, we sought to explore difference serum 25-hydroxyvitamin D3 , 1,25-dihydroxyvitamin levels between infertile patients and fertile men, find influence semen quality. The analysis level showed no significant men. However, in oligospermia (P < 0.05), asthenospermia 0.01), oligoasthenospermia 0.05)...
Diabetic peripheral polyneuropathy is associated with decrements in motor/sensory neuron myelination, nerve conduction and muscle function; however, the mechanisms of reduced myelination diabetes are poorly understood. Chronic elevation oxidative stress may be one potential determinants for demyelination as lipids proteins important structural constituents myelin highly susceptible to oxidation. The goal current study was determine whether there a link between protein oxidation/misfolding...
We evaluated the effects of administration 1,25-dihydroxyvitamin D (1,25(OH)2D) during pregnancy on relieving adverse outcomes preeclampsia and pathologic biochemical changes in reduction uteroplacental perfusion (RUPP) model rats. On day 1, 7, 14 pregnancy, rats pregnant RUPP plus 1,25(OH)2D (RUPP+VD) group (n = 15) received 120 ng/100 g body weight/week by subcutaneous injection, while normal 12) 14) vehicle (saline solution). 19 after measure blood pressure cardiac function urine...
It is estimated that ∼1% of European ancestry patients clinically diagnosed with type 1 diabetes (T1D) actually have monogenic forms the disease. Because much lower incidence true T1D in East Asians, we hypothesized percentage would be higher. To test this, sequenced exome 82 Chinese Han but negative for three autoantibodies. Analysis focused on established or proposed genes. We found credible mutations 18 autoantibody-negative (22%). All had consensus pathogenicity support by five...
This study described a case of plurihormonal tumor associated with papillary thyroid carcinoma (PTC) and summarized the treatment approaches for similar cases, while also exploring underlying pathogenesis. The patient exhibited symptoms indicative acromegaly, central hyperthyroidism, hyperprolactinemia. A glucose loading test demonstrated persistently elevated growth hormone (GH) levels, function tests revealed inappropriate stimulating (TSH) secretion. Imaging pituitary gland 26 × 19 mm...
Background: Immune Checkpoint Inhibitor (ICPi) therapy has revolutionized cancer treatment but can lead to immune-related adverse events (irAE), including thyroid dysfunction. The impact of ICPi on patients with pre-existing autoimmune diseases (PATD), particularly the development Graves' disease, remains poorly understood. Case Description: We provide first complete case disease in a patient who already had Hashimoto's thyroiditis.. patient, 52-year-old male, was diagnosed lung...
Objective The aim of this retrospective study was to investigate the relevance influenza A virus (IAV) in acutely exacerbating airway inflammatory response and disrupting immune function elderly COPD patients. Methods group conducted a pre-test: using multiplex combined real-time PCR detection kits Multiple real⁃time used detect twenty-four pathogens, 385 patients clinically diagnosed with were tested for viral nucleic acid throat swabs. At same time, peripheral blood leukapheresis collected...
We evaluated the effects of drug therapy on T lymphocyte subsets and their associations with recurrent chronic bronchitis (CB) attacks. A total 162 CB patients treated from April 2020 to 2021 were selected. All underwent anti-infective, cough-relieving, phlegm-eliminating treatment, as detailed in Clinical Pathway for Chronic Bronchitis. They divided into a attack group (n=95) non-recurrent (n=67). Changes at different time points treatment number attacks analyzed. Associated factors...
Cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary (COPD), but few studies have been conducted to identify CVD risk in COPD patients. This study was develop predictive model of patients based on the National Health and Nutrition Examination Survey (NHANES) database.