A5100400630- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Thyroid Disorders and Treatments
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Hepatitis B Virus Studies
- Hematological disorders and diagnostics
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Adrenal Hormones and Disorders
- Metabolism, Diabetes, and Cancer
- Immunodeficiency and Autoimmune Disorders
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Hormonal Regulation and Hypertension
- Retinal Diseases and Treatments
National Center for Chronic and Noncommunicable Disease Control and Prevention
2014-2025
Nanjing Medical University
2015-2025
Xinjiang Medical University
2025
Dalian Medical University
2023-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
ZheJiang Institute For Food and Drug Control
2024
Jiangsu Province Hospital
2013-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Shanghai First People's Hospital
2023
Developing untethered millirobots that can adapt to harsh environments with high locomotion efficiency is of interest for emerging applications in various industrial and biomedical settings. Despite recent success exploiting soft materials impart sophisticated functions which are not available conventional rigid robotics, it remains challenging achieve superior performances both wet dry conditions. Inspired by the flexible, soft, elastic leg/foot structures many living organisms, here we...
Intact and stable bone reconstruction is ideal for the treatment of periodontal destruction but remains challenging. In research, biomaterials are used to encapsulate stem cells or bioactive factors regeneration, but, best our knowledge, using a supramolecular hydrogel their sustained release in defect areas promote regeneration has not been reported. Herein, we well-studied hydrogelator, NapFFY, coassemble with SDF-1 BMP-2 prepare hydrogel, SDF-1/BMP-2/NapFFY. vitro vivo results indicated...
The current epidemic status of diabetic retinopathy in China is unclear. A national prevalence survey complications was conducted. 50,564 participants with gradable non-mydriatic fundus photographs were enrolled. rates (95% confidence intervals) and vision-threatening 16.3% (15.3%-17.2%) 3.2% (2.9%-3.5%), significantly higher the northern than southern regions. differences between those who had not attained a given metabolic goal more pronounced for Hemoglobin A1c blood pressure low-density...
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Abstract Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally citrulline, and this activity has been associated with the onset progression of multiple cancers. However, a role for PADI2 in endometrial cancer (EC) not previously explored. This study demonstrates that is EC proregression. Mechanistically, interacting catalyzing MEK1 citrullination at 113/189 facilitates on extracellular signal‐regulated protein kinases 1/2 (ERK1/2) phosphorylation,...
The association between cognitive function, healthy lifestyle, and mortality remains understudied in large Chinese cohorts. In this nationwide 10-year prospective study of 24,657 older adults, we assessed Mini-Mental State Examination (MMSE) categories (<18, 18 to 23, 24 27, 28 30) a seven-component lifestyle score (0 7) for their relationships with all-cause, cardiovascular, cerebrovascular mortality. Compared individuals scoring 30 on the MMSE, lower scores were linked elevated all-cause...
Objectives Follicular helper T (Tfh) cells exert an important role in autoimmune diseases. Whether it might be involved type 1 diabetes (T1D) is unknown. Our aim was to investigate the of Tfh patients with T1D and effect anti-CD20 monoclonal antibody (rituximab) on from patients. Patients Methods Fifty-four 37 healthy controls were enrolled current study. 20 those treated rituximab. The frequencies circulating CD4+CXCR5+ICOS+T analyzed by flow cytometry. serum autoantibodies detected...
Abstract Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting full-length S protein of SARS-CoV-2 have been authorized for emergency use. Recently, we developed a lipid nanoparticle-encapsulated (mRNA-LNP) encoding receptor-binding domain (RBD) (termed ARCoV), which confers complete protection mouse model. Herein, further characterized efficacy ARCoV nonhuman primates and long-term stability under normal...
Abstract Peptidylarginine deiminase (PADI) enzymes are increasingly being associated with the regulation of chromatin structure and gene activity via histone citrullination. As one PADI family members, PADI1 has been mainly reported to be expressed in epidermis uterus, where protein keratinocytes is thought promote differentiation by citrullinating filament proteins. However, roles preimplantation development have not addressed. Using a PADI1-specific inhibitor Padi1-morpholino knockdown, we...
ABSTRACT Background : Paroxysmal kinesigenic dyskinesia is the most common type of paroxysmal dyskinesia. Approximately half cases worldwide are attributable to proline‐rich transmembrane protein 2 mutations. Objective The objective this study was investigate potential causative genes and clinical characteristics in – negative patients with Methods We analyzed manifestations performed exome sequencing a cohort 163 2–negative probands, followed by filtering data movement disorders gene panel....
Abstract Excessive inflammation‐associated unregulated coagulation leads to disseminated intravascular (DIC) and mortality in patients with sepsis worldwide, current clinical treatment is unsatisfactory. Recent studies have shown that circulating cell‐free DNA (cfDNA) neutrophil extracellular traps (NETs), act as potent pro‐inflammation pro‐coagulation agents, revealing a mechanistic link between innate immunity coagulation. After establishing definite correlation cfDNA dysfunctional...
How do NR4A receptors drive decidualization of human endometrial stromal cells (hESCs)? modulate by transcriptional activation FOXO1A, and in adenomyosis patients, the reduced expression eutopic endometrium may represent a novel mechanism to explain impaired subfertility. A close relationship between subfertility has been established. In cells, orphan nuclear receptor is regulator decidualization. Eutopic tissues hESCs from fertile controls (n = 56) patients 27) were collected for vitro...
It is estimated that ∼1% of European ancestry patients clinically diagnosed with type 1 diabetes (T1D) actually have monogenic forms the disease. Because much lower incidence true T1D in East Asians, we hypothesized percentage would be higher. To test this, sequenced exome 82 Chinese Han but negative for three autoantibodies. Analysis focused on established or proposed genes. We found credible mutations 18 autoantibody-negative (22%). All had consensus pathogenicity support by five...
<title>Abstract</title> Background: Spondylitis, particularly infectious forms caused by Mycobacterium tuberculosis and Brucella species, presents significant clinical challenges due to overlapping symptoms diagnostic difficulties. Accurate differentiation is crucial for effective treatment, necessitating advanced imaging techniques radiomics enhance precision improve patient outcomes in cases of TB brucella spondylitis. Methods This retrospective cohort study included 165 patients diagnosed...
Abstract Background Cardio-kidney-metabolic (CKM) syndrome is defined as a systemic disorder characterized by pathophysiological interactions among metabolic risk factors, chronic kidney disease, and the cardiovascular system, leading to multiorgan dysfunction high rate of adverse outcomes. However, prevalence CKM adults in China unknown. Objectives The aim this study was assess its stages mainland China. Methods This cross-sectional included two nationally representative data from 41 088...
Abstract Background Metabolic dysfunction–associated steatotic liver disease is prevalent in type 2 diabetes (T2D) and exacerbates hyperglycemia, but its impact on postprandial glucagon suppression remains unclear. Objective To investigate the association between hepatic steatosis impaired during oral glucose tolerance tests (OGTT), to evaluate mediating role of dysregulation linking fat glycemic control. Design methods In this cross-sectional study, 604 patients with T2D underwent...
Methotrexate (MTX) use in inflammatory bowel disease (IBD) is complicated by unpredictable efficacy and toxicity. In rheumatoid arthritis, total individual red blood cell MTX polyglutamates (RBC MTXGlu1-5) correlate with activity possibly toxicity, therefore may be useful guiding treatment. It unclear if this applies IBD. The aim of pilot study was to measure RBC MTXGlu1-5 concentrations patients IBD see these relate adverse effects. MTXGlu1--5 were measured on three occasions 18 receiving...
Perfluorooctanoic acid (PFOA) is a common environmental pollutant that has been associated with various diseases, including cancer. We explored the molecular mechanisms underlying PFOA-induced endometrial cancer cell invasion and migration. PFOA treatment enhanced migration by human Ishikawa cells, which correlated decreased E-cadherin expression, marker of epithelial-mesenchymal transition. also induced activation ERK1/2/mTOR signaling. Treatment rapamycin, an mTOR inhibitor, antagonized...
Abstract Signaling abnormalities play important roles during podocyte injury and have been indicated as crucial events for triggering many glomerular diseases. There is emerging evidence demonstrating significant improvements in preventing renal restoring podocytes after islet transplantation. However, whether signaling affect the therapeutic efficacy of transplantation remain unclear. This study was established to investigate impact Notch-1 activation on restoration Experiments were...