A5046299375- RNA modifications and cancer
- RNA Research and Splicing
- Advanced Sensor and Energy Harvesting Materials
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Graph theory and applications
- Conducting polymers and applications
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Sesquiterpenes and Asteraceae Studies
- Cancer-related molecular mechanisms research
- Lanthanide and Transition Metal Complexes
- Retinal Development and Disorders
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Parathyroid Disorders and Treatments
- Magnetism in coordination complexes
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Nanoplatforms for cancer theranostics
- Pain Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
National Defense Medical Center
2015-2025
Shenyang Agricultural University
2024-2025
University of Science and Technology Beijing
2025
Huazhong University of Science and Technology
2018-2024
Xian Central Hospital
2024
Sun Yat-sen University
2018-2024
Peking University
2022-2024
First Affiliated Hospital of Zhengzhou University
2024
Shanghai Ocean University
2024
Anhui Medical University
2017-2024
This paper examines operation models of multiple virtual power plants (multiVPPs), aiming at unified management the multiVPP through VPP central controller, which reveals controllability as source and load in general. Two will be introduced this paper: 1) dispatch model; 2) game theoretic model for dispatch. In model, considering interactive coordination between energy consumers, a demand response based on time-of-use pricing mechanism interruptible loads is employed. And then optimal...
The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence response to various signals for within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat deacetylated deacetylase CobB enzymatically vitro vivo Salmonella Typhimurium. Specifically, lysine residue 201(K201) winged helix–turn–helix motif at C-terminal DNA-binding domain of acetylated, its acetylation level decreases dramatically when encounter low magnesium, acid stress or...
Abstract Phototherapy has emerged as a powerful approach for interrupting β‐amyloid (Aβ) self‐assembly. However, deeper tissue penetration and safer photosensitizers are urgent to be exploited avoiding damaging nearby normal tissues improving therapeutic effectiveness. A hydrogen‐bonded organic framework (HOF)‐based NIR‐II photooxygenation catalyst is presented here settle the abovementioned challenges. By encapsulating pyridinium hemicyanine dye DSM with large two‐photon absorption (TPA)...
Abstract Induced neural stem cells (iNSCs) reprogrammed from somatic have great potentials in cell replacement therapies and vitro modeling of diseases. Direct conversion fibroblasts into iNSCs has been shown to depend on a couple key progenitor transcription factors (TFs), raising the question whether such direct reprogramming can be achieved by non-neural TFs. Here we report that TF Ptf1a alone is sufficient directly reprogram mouse human self-renewable capable differentiating functional...
Abstract Inorganic halide perovskite (HP)‐based photodetectors (PDs) have exhibited fast response speed and high responsivity, but with low detectivity due to the dark current of devices. Additionally, intrinsic instability HPs interface deterioration originating from ion migration inhibit their practical applications severely. A tunneling organic layer is introduced solve both these problems. Light‐induced charge carriers can flow across interfacial (poly(methyl methacrylate), PMMA)...
Abstract Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally citrulline, and this activity has been associated with the onset progression of multiple cancers. However, a role for PADI2 in endometrial cancer (EC) not previously explored. This study demonstrates that is EC proregression. Mechanistically, interacting catalyzing MEK1 citrullination at 113/189 facilitates on extracellular signal‐regulated protein kinases 1/2 (ERK1/2) phosphorylation,...
Abstract Human ribosomes have long been thought to be uniform factories with little regulatory function. Accumulating evidence emphasizes the heterogeneity of ribosomal protein (RP) expression in specific cellular functions and development. However, a systematic understanding functional relevance RPs is lacking. Here, we surveyed translational transcriptional changes after individual knockdown 75 RPs, 44 from large subunit (60S) 31 small (40S), by Ribo-seq RNA-seq analyses. Deficiency...
Summary The phytohormones, jasmonates (JAs), mediate many plant developmental processes and their responses to important environmental stresses, such as herbivore attack. Bioactive JAs are perceived by CORONATINE INSENSITIVE (COI)‐receptors, associated JAZ proteins, activate downstream responses. To date, the JA receptors of monocot crop plant, rice, remain be explored. Here, we studied all three rice COI OsCOI1a, OsCOI1b, OsCOI2, ligand binding, genome editing, phenotyping examining some...
Abstract As a common pathology of many ocular disorders such as diabetic retinopathy and glaucoma, retinal ischemia/reperfusion (IR) triggers inflammation microglia activation that lead to irreversible damage. The detailed molecular mechanism underlying IR injury, however, remains poorly understood at present. Here we report the bioinformatic identification lncRNA 1810058I24Rik ( 181-Rik ) was shown encode mitochondrion-located micropeptide Stmp1. Its deficiency in mice protected ganglion...
The primary treatment for hepatocellular carcinoma (HCC) involves surgical removal of the tumor, but this creates a favorable environment proliferation and spread residual circulating cancer cells. development remimazolam-based balanced anesthesia is crucial future antitumor applications. It important to understand mechanisms cytotoxicity HCC in detail. We performed cell viability analysis, western blotting reverse transcription-polymerase chain reaction flow cytometry analysis two lines,...
The controlled morphology and luminescence properties of CsPbBr<sub>3</sub> perovskite quantum dots have been successfully achieved in glass through manipulating the rigidity network structure.
Open AccessCCS ChemistryRESEARCH ARTICLE1 Dec 2021Tuning Magnetic Relaxation in Square-Pyramidal Dysprosium Single-Molecule Magnets Using Apical Alkoxide Ligands Zhenhua Zhu, Yi-Quan Zhang, Xiao-Lei Li, Mei Guo, Jingjing Lu, Shuting Liu, Richard A. Layfield and Jinkui Tang Zhu State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute Applied Chemistry, Chinese Academy Sciences, 130022 University Beijing 100049 Google Scholar More articles by this author , Zhang...
Open AccessCCS ChemistryRESEARCH ARTICLE7 Dec 2022Air-Stable Dy(III)-Macrocycle Enantiomers: From Chiral to Polar Space Group Zhenhua Zhu†, Chen Zhao†, Quan Zhou, Shuting Liu, Xiao-Lei Li, Akseli Mansikkamäki and Jinkui Tang Zhu† State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute Applied Chemistry, Chinese Academy Sciences, 130022 University Beijing 100049 , Zhao† Science Technology China, Hefei 230026 Zhou Liu Li *Corresponding authors: E-mail Address: [email...
ABSTRACT The ability of terrestrial vertebrates to find food and mating partners, avoid predators, relies on the detection chemosensory information. Semiochemicals responsible for social sexual behaviors are detected by neurons vomeronasal organ (VNO), which transmits information accessory olfactory bulb. sensory epithelium most mammalian species contains a uniform system; however, rodents marsupials have developed more complex binary system, containing (VSNs) expressing receptors either V1R...
Abstract Five new and seven known mono‐sesquiterpenoids ( 1 – 5 6 12 , resp.) together with five lindenane‐type disesquiterpenoids, 13 17 were isolated from the whole plant of Chloranthus henryi. Based on spectroscopic methods, structures established to be (5 S ,6 R ,8 ,10 )‐6‐hydroxyeudesma‐4(15),7(11)‐diene‐12,8‐olide ), α ‐hydroxyeudesma‐4(15),7(11),8(9)‐triene‐12,8‐olide 2 8,12‐epoxy‐1 β ‐hydroxyeudesma‐4(15),7,11‐trien‐6‐one 3 12‐oxochloraniolide A 4 (4...
HilD, a dominant regulator of Salmonella pathogenicity island 1, can be acetylated by protein acetyltransferase (Pat) in Typhimurium, and the acetylation is beneficial to its stability. However, underlying mechanism HilD stability regulated not clear. We show here that lysine 297 (K297) located helix-turn-helix motif, Pat. Acetylation K297 increases stability, but reduces DNA-binding affinity. In turn, deacetylated enhances ability decreases Under 1-inducing condition, level down-regulated....
Fourteen new ent-abietane-type diterpenoids, sessilifols A–N (1–14), and three related norditerpenoids (15–17) were isolated from Chloranthus sessilifolius. The absolute configurations determined by single-crystal X-ray diffraction analysis, the modified Mosher's method, and/or observed Cotton effects in their electronic circular dichroism spectra. Sessilifols A (1) B (2) possess an uncommon five-membered C-ring rearranged oxidative cleavage of C-13/C-14 bond abieta-7,13-diene followed...
Significance Organogenesis, an evolutionarily refined process which is so complicated, delicate, yet replicable, all about time and space. Only until recently have scientists realized that the temporal identity of Drosophila neuroblasts controlled by cascades transcription factors (tTFs), but regulation mechanism poorly understood in vertebrates. We show Foxn4 functions as a tTF to confer mammalian retinal progenitors (RPCs) with competence generate mid/late-early cell types while...