A5084017583- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Animal Behavior and Reproduction
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Infant Development and Preterm Care
- Child Nutrition and Water Access
- Birth, Development, and Health
Albany State University
2020-2024
University at Albany, State University of New York
2019-2024
Savanna Institute
2020-2023
National Brain Research Centre
2013
The physiological performance of any sensory organ is determined by its anatomy and physical properties. Consequently, complex structures with elaborate features have evolved to optimize stimulus detection. Understanding these their nature forms the basis for mechanistic insights into function. Despite crucial role as a sensor pheromones other behaviorally instructive chemical cues, vomeronasal (VNO) remains poorly characterized mammalian structure. Fundamental principles physico-mechanical...
ABSTRACT The ability of terrestrial vertebrates to find food and mating partners, avoid predators, relies on the detection chemosensory information. Semiochemicals responsible for social sexual behaviors are detected by neurons vomeronasal organ (VNO), which transmits information accessory olfactory bulb. sensory epithelium most mammalian species contains a uniform system; however, rodents marsupials have developed more complex binary system, containing (VSNs) expressing receptors either V1R...
Neuronal identity dictates the position in an epithelium, and ability to detect, process, transmit specific signals specified targets. Transcription factors (TFs) determine cellular via direct modulation of genetic transcription recruiting chromatin modifiers. However, our understanding mechanisms that define neuronal their magnitude remain a critical barrier elucidate etiology congenital neurodegenerative disorders. The rodent vomeronasal organ provides unique system examine detail...
The vomeronasal organ (VNO) is a part of the accessory olfactory system, which detects pheromones and chemical factors that trigger spectrum sexual social behaviors. epithelium (VNE) shares several features with main (MOE). However, it distinct neuroepithelium populated by chemosensory neurons differ from sensory in cellular structure, receptor expression, connectivity. rodents comprises (SE) thin non-sensory (NSE) morphologically resembles respiratory epithelium. Sox2-positive cells have...
During embryonic development, symmetric ectodermal thickenings (olfactory placodes) give rise to several cell types that comprise the olfactory system, such as those form terminal nerve ganglion (TN), gonadotropin releasing hormone-1 (GnRH-1) neurons and other migratory in rodents. Even though genetic heterogeneity among these are documented, unidentified populations arising from placode remain. One candidate identify placodal derived developing nasal area is transcription factor Isl1, which...
ABSTRACT The vomeronasal organ (VNO) contains two main types of sensory neurons (VSNs) that express distinct receptor (VR) genes and localize to specific regions the neuroepithelium. Morphogenic signals are crucial in defining neuronal identity network formation; however, if what control maturation homeostasis VSNs is largely unexplored. Here, we found transforming growth factor β (TGFβ) bone morphogenetic protein (BMP) signal transduction postnatal mice, with BMP signaling being restricted...
Protein malnutrition during early development has been correlated with cognitive and learning disabilities in children, but the neuronal deficits caused by long-term protein deficiency are not well understood. We exposed rats from gestation up to adulthood a protein-deficient (PD) diet, emulate chronic humans. The offspring exhibited significantly impaired performance on ‘Gap-crossing’ (GC) task after reaching maturity, behavior that shown depend normal functioning of somatosensory cortex....
Summary The accessory olfactory system is a unique model that can give insights on how the neurons establish and maintain their identity, connectivity. vomeronasal organ (VNO) contains two distinct populations of sensory (VSNs) each with specific innervation patterns to bulb (AOB). Though morphogenic signals are critical in defining various neuronal populations, signaling profiles influence VSN population remains unknown. Here, we found pronounced BMP gradient within basal VSNs. By...
Abstract The Vomeronasal organ (VNO) is a part of the accessory olfactory system, which responsible for detecting pheromones, chemical factors that trigger spectrum sexual and social behaviors. vomeronasal epithelium (VNE) shares several features with main (MOE). However, it distinct neuroepithelium populated by chemosensory neurons differ from sensory (OSNs) in cellular structure, receptor expression, connectivity. rodents comprises thin non-sensory morphologically resembles respiratory...
Abstract During embryonic development, symmetric ectodermal thickenings (olfactory placodes) give rise to several cell types that comprise the olfactory system, such as those form terminal nerve ganglion (TN), gonadotropin releasing hormone-1 (GnRH-1) neurons and other migratory in rodents. Even though genetic heterogeneity among these are documented, unidentified populations arising from placode remain. One candidate identify placodal derived developing nasal area is transcription factor...
SUMMARY Neuronal identity dictates the position in an epithelium, and ability to detect, process, transmit specific signals specified targets. Transcription factors (TFs) determine cellular via direct modulation of genetic transcription recruiting chromatin modifiers. However, our understanding mechanisms that define neuronal their magnitude remains a critical barrier elucidate etiology congenital neurodegenerative disorders. The rodent vomeronasal organ provides unique system examine detail...
Abstract The ability of terrestrial vertebrates to find food, mating partners and avoid predators heavily relies on the detection chemosensory information from environment. olfactory system most vertebrate species comprises two distinct systems usually referred as main accessory system. Olfactory sensory neurons epithelium detect transmit odor bulb (MOB), while vomeronasal organ semiochemicals responsible for social sexual behaviors (AOB). (VNE) mammalian contains uniform (VN) with (VSNs)...