A5102845401- Eicosanoids and Hypertension Pharmacology
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Trypanosoma species research and implications
- Lymphoma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- GDF15 and Related Biomarkers
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Cardiac electrophysiology and arrhythmias
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Cardiomyopathy and Myosin Studies
- Acute Lymphoblastic Leukemia research
- Plant-derived Lignans Synthesis and Bioactivity
- Virus-based gene therapy research
- Cardiovascular Function and Risk Factors
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Viral-associated cancers and disorders
Huazhong University of Science and Technology
2014-2023
Tongji Hospital
2014-2023
Goethe University Frankfurt
2023
St. Elizabeth Youngstown Hospital
2022
Mercy Health
2022
Central Hospital of Wuhan
2018-2021
Wuhan Puai Hospital
2020
Wuhan University
2017
Vanderbilt University Medical Center
2016
National Patient Safety Foundation
2016
Mitsugumin 53 (MG53 or TRIM72), a striated muscle-specific E3 ligase, promotes ubiquitin-dependent degradation of the insulin receptor and substrate-1 subsequently induces resistance, resulting in metabolic syndrome type 2 diabetes mellitus (T2DM). However, it is unknown how MG53 from muscle regulates systemic response energy metabolism. Increasing evidence demonstrates that secretes proteins as myokines cardiokines regulate processes. We hypothesize may act myokine/cardiokine, contributing...
Kidney diseases, including chronic kidney disease (CKD) and acute injury (AKI), are associated with inflammation. The mechanism that regulates inflammation in these renal injuries remains unclear. Here, we demonstrated p300/CBP-associated factor (PCAF), a histone acetyltransferase, was overexpressed the kidneys of db/db mice lipopolysaccharide (LPS)-injected mice. Moreover, elevated acetylation, such as H3K18ac, up-regulation some inflammatory genes, ICAM-1, VCAM-1, MCP-1, were found upon...
Mitochondrial DNA (mtDNA) copy number variation (CNV), which reflects the oxidant-induced cell damage, has been observed in a wide range of human diseases. However, whether it correlates with heart failure, is closely related to oxidative stress, never elucidated before. We aimed systematically investigate associations between leukocyte mtDNA CNV and failure risk prognosis. A total 1700 hospitalized patients age- sex-matched community population were consecutively enrolled this observational...
Recent genome-wide association studies identified the APOA5/A4/C3/A1 gene cluster polymorphisms influencing triglyceride level and risk of coronary artery disease (CAD). The purposes this study were to fine-map signals in then explore clinical relevance CAD potential underlying mechanisms. We resequenced 200 patients with extremely high levels (≥10 mm/l) healthy control subjects who ethnically matched genotyped 20 genetic markers among 4,991 participants Chinese Han ethnicity. Subsequently,...
Abstract Background Phenylacetylglutamine (PAGln)—a newly discovered microbial metabolite produced by phenylalanine metabolism—is reportedly associated with cardiovascular events via adrenergic receptors. Nonetheless, its association outcomes in heart failure (HF) patients remains unknown. Objectives This study aimed to prospectively investigate the prognostic value of PAGln for HF. Methods Plasma levels were quantified liquid chromatography‐tandem mass spectrometry. We first assessed...
Cisplatin resistance is a major cause of treatment failure in advanced ovarian cancer. The limited evidence shows the paradoxical regulation miR-205 on chemotherapy Herein, we found that miR-205-5p was enormously increased cisplatin-resistant C13K cancer cells compared with its cisplatin-sensitive OV2008 parental using miRNA microarrays, which further verified by quantitative PCR. Furthermore, confirmed inhibition upregulated PTEN and subsequently attenuated downstream target p-AKT, inversed...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids (AA) to form epoxyeicosatrienoic (EETs), which exert beneficial roles in the treatment of cardiovascular diseases, but little is known about its role on adventitial remodeling.We used C57BL/6J mice vivo and primary rat fibroblasts (AFs) vitro treated with Angiotensin II investigate effects CYP2J2 gene delivery exogenous EETs administration remodeling.CYP/sEH system was found exist human adventitia, involved remodeling process....
We sought to investigate the association of single nucleotide polymorphisms (SNPs) genes involved in βAR signaling with response patients blockers. A total 2403 hospitalized chronic heart failure (HF) were enrolled a multicenter observational study as first cohort and followed up for mean period 20 months. Genes β1AR, β2AR, major cardiac G-protein-coupled receptor kinases (GRKs) GRK2 GRK5 analyzed identify SNPs, stratified according genotypes. second independent enrolling 919 HF was applied...
Abstract Apolipoprotein C-III (APOC3) is a key regulator of plasma triglycerides levels. Increasing evidence has shown that loss-of-function mutations in APOC3 associated with reduction levels and will confer benefit patients at high risk for cardiovascular disease. However, these favorable were extremely distribution discrepant among different ethnics. In this study, the gene was resequenced we identified common variant which located microRNA-binding site would affect its expression...
Background Genetic architecture of coronary artery disease (CAD) is still to be defined. Since low density lipoprotein receptor-related protein 6 (LRP6) gene play critical roles in Wnt signal transduction which are important for vascular development and endodermis specification, we therefore resequenced it search mutations CAD patients. Methods We systemically sequenced all the exons promoter region LRP6 a sample 380 early onset patients control subjects Chinese. Results In total, identified...
Heart failure is characterized by immune activation leading to production and release of proinflammatory cytokines. Interleukin 17A (IL-17A) a cytokine multiple lines evidence from animal human studies suggest crucial roles IL-17A in heart failure. Therefore, we investigated whether common polymorphisms genes IL17A IL17RA (coding interleukin 17 receptor A) contribute genetic predisposition adverse clinical outcomes associated with it. A total 1713 adult patients congestive age- sex-matched...
// Meng Zhang 1, * , Jing Wang Lingwei Jia 2 Jin Huang 1 Cheng He Fuqing Hu Lifei Yuan Guihua Mingxia Yu and Zhuoya Li Department of Immunology, Basic Medical College, Tongji Huazhong University Science Technology, Wuhan 430030, P.R. China Molecular Center, Hospital, These authors have contributed equally to this work Correspondence to: Li, email: zhuoyali@mails.tjmu.edu.cn Keywords: activation-induced cell death, transmembrane TNF-α, secretory reverse signaling, apoptosis Received: June 29,...
Macrophages exhibit distinct phenotypes in response to environmental signals. The polarization of M1 macrophages plays an essential role the inflammatory response. However, specific molecular mechanisms regulating during macrophage remain be further understood. Here, we found that histone acetyltransferase P300/CBP-associated factor (PCAF) was a potential negative regulator During polarization, gradually reduced, but PCAF expression increased. Furthermore, overexpression significantly...
Rapidly determining the complex genetic basis of Hypertrophic cardiomyopathy (HCM) is vital to better understanding and optimally managing this common polygenetic cardiovascular disease. A rapid custom Ion-amplicon-resequencing assay, covering 30 commonly affected genes HCM, was developed validated in 120 unrelated patients with HCM facilitate diagnosis With HCM-specific panel only 20 ng input genomic DNA, physicians can, for first time, go from blood samples variants within a single day. On...