A5022618127- Viral Infectious Diseases and Gene Expression in Insects
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Aquaculture disease management and microbiota
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Silkworms and Sericulture Research
- Virus-based gene therapy research
- Plant Virus Research Studies
- Silk-based biomaterials and applications
- RNA Research and Splicing
- Animal Virus Infections Studies
- RNA modifications and cancer
- Insect symbiosis and bacterial influences
- Viral Infections and Immunology Research
- Neurobiology and Insect Physiology Research
- Wildlife Ecology and Conservation
- Insect and Arachnid Ecology and Behavior
- Dermatologic Treatments and Research
- Phytochemistry and Biological Activities
- Mycobacterium research and diagnosis
- Natural Compound Pharmacology Studies
Soochow University
2016-2025
Biotechnology Research Institute
2014-2025
Jiangxi Agricultural University
2017-2025
China Pharmaceutical University
2017-2025
Second Affiliated Hospital of Zhejiang University
2025
Poultry Research Institute
2021-2024
ShanghaiTech University
2024
Karamay Central Hospital of Xinjiang
2024
Inner Mongolia Agricultural University
2023
South China Agricultural University
2022-2023
The large and complex gut microbiota in animals has profound effects on feed utilization metabolism. Currently, gastrointestinal diseases due to dysregulated are considered important factors that limit growth of the captive forest musk deer population. Compared with deer, wild have a wider feeding range no dietary limitations, their relatively natural state. However, reports compared between deer. To gain insight into composition under different food-source conditions, we employed...
Background The hypertrophic scar (HS) is a serious fibrotic skin condition and major clinical problem. Interleukin-10 (IL-10) has been identified as prospective scar-improving compound based on preclinical trials. Our previous work showed that IL-10 anti-fibrotic effects in transforming growth factor (TGF)-β1-stimulated fibroblasts, well potential therapeutic benefits for the prevention reduction of formation. However, relatively little known about mechanisms underlying IL-10-mediated...
Chemotherapy-induced myelosuppression (CIM) significantly impairs hematopoiesis. Trilaciclib (TC), originally developed for oncology application, is the only FDA-approved CDK4/6 inhibitor CIM, which effectively protects bone marrow cells by inhibiting their proliferation. In this study, a series of TC derivatives were designed and synthesized as inhibitors (CDK4/6i) alleviating CIM. Among these, 42 displayed potent inhibitory activity (IC50 = 11 nM), lower cytotoxicity (CC50 > 100 μM) showed...
Abstract Inflammation is a protective response that implicated in bacterial enteritis and other fish diseases. The inflammatory mechanisms behind Aeromonas hydrophila infections remain poorly understood. In this study, we performed de novo grass carp transcriptome assembly using Illumina’s Solexa sequencing technique. On basis carried out comparative analysis of intestinal transcriptomes from A. -challenged physiological saline solution (PSS/mock) fish, 315 genes were up-regulated 234...
The gut microbiota has a crucial role in the growth, development and environmental adaptation host insect. objective of our work was to investigate healthy silkworm Bombyx mori changes after infection B. cypovirus (BmCPV). Intestinal contents infected larvae fifth instar were collected at 24, 72 144 h post with BmCPV. bacteria analyzed by pyrosequencing 16S rRNA gene. 147(135) 113(103) genera found content control female (male) BmCPV-infected larvae, respectively. In general, microbial...
The gut ecosystem is characterized by dynamic and reciprocal interactions between the host bacteria. Although characterizing microbiota for herbivores has become recognized as important tool gauging species health, no study to date investigated bacterial communities evaluated age-related dynamics of musk deer. Moreover, gastrointestinal diseases have been hypothesized be a limiting factor population growth in captive Here, high-throughput sequencing 16S rRNA gene was used profile fecal...
Diarrhea constitutes one of the most common diseases affecting survival captive musk deer and is usually caused by an imbalance in intestinal microbiota. Currently, research regarding structure function microbiota diarrheic lacking. Therefore, present study, high-throughput 16S-rRNA gene sequencing was used to analyze feces healthy (HMD) (n = 8) with mild (MMD) 8), severe 5) (SMD) diarrhea compare difference under various physiological conditions. The results showed that diversity HMD fecal...
The gut microbiota plays a key role in the nutritional ecology of ruminants, and host diet has significant effect on these microbial communities. Longitudinal studies assessing variation seasonal animals can provide comparative context for interpreting adaptive significance such changes. However, few have investigated effects seasonally-related dietary shifts communities endangered forest musk deer (FMD), national breeding programs need this information to promote growth captive populations....
Soil bacteria are important drivers of biogeochemical cycles and participate in many nutrient transformations the soil. Meanwhile, bacterial diversity community composition related to soil physic-chemical properties vegetation factors. However, how factors affect is poorly understood, especially for associated with evergreen deciduous trees subtropical forest ecosystems. In present paper, microbial communities rhizospheric soils different types were analyzed by Illumina MiSeq sequencing...
Abstract In plants, leaf is crucial for photosynthesis and respiration. Leaf area quantity are important vegetables to increase biomass. The process of development involves coordinated regulation among small RNAs, transcription factors hormones. Here, we found size were regulated by NF-YA2 NF-YA10 in Arabidopsis . overexpression increased biomass accumulation through promoting growth cell expansion. expressed SAM vasculature. Endogenous IAA content reduced 20% 24% transgenic plants...
The pathogenesis of Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection is unclear, although accumulating evidence indicates that circular RNAs (circRNAs), which act as competing endogenous or positive regulators, play important roles in regulating gene expression eukaryotes and, thus, may a role BmCPV infections. To explore the and biological functions circRNAs silkworm midgut following infection, circRNA profiles normal tissue (control) BmCPV-infected (test) were determined using...