A5108141952- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Alzheimer's disease research and treatments
- Acute Myeloid Leukemia Research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Acute Lymphoblastic Leukemia research
- Cardiac electrophysiology and arrhythmias
- Bioactive Compounds and Antitumor Agents
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Connexins and lens biology
- Functional Brain Connectivity Studies
- Global Cancer Incidence and Screening
- Cancer, Lipids, and Metabolism
- Natural Compounds in Disease Treatment
- Biochemical effects in animals
- Cerebrovascular and Carotid Artery Diseases
- Estrogen and related hormone effects
- Lysosomal Storage Disorders Research
- Acute Ischemic Stroke Management
- Clinical Laboratory Practices and Quality Control
- Ocular Diseases and Behçet’s Syndrome
Soochow University
2025
Beijing Tian Tan Hospital
2020-2025
National Clinical Research Center for Digestive Diseases
2018-2025
Capital Medical University
2013-2025
Xi'an Shiyou University
2024-2025
China Pharmaceutical University
2021-2025
Northern Jiangsu People's Hospital
2025
Hangzhou Cancer Hospital
2024
Yale Cancer Center
2016-2024
Yale University
2009-2024
Alzheimer's disease (AD) is characterized by the age-related deposition of β-amyloid (Aβ) 40/42 peptide aggregates in vulnerable brain regions. Multiple levels evidence implicate a central role for Aβ pathophysiology AD. peptides are generated regulated cleavage an ≈700-aa precursor protein (βAPP). Full-length βAPP can undergo proteolytic either within domain to generate secreted sβAPPα or at N- and C-terminal domain(s) amyloidogenic peptides. Several epidemiological studies have reported...
Chemotherapy-induced myelosuppression (CIM) significantly impairs hematopoiesis. Trilaciclib (TC), originally developed for oncology application, is the only FDA-approved CDK4/6 inhibitor CIM, which effectively protects bone marrow cells by inhibiting their proliferation. In this study, a series of TC derivatives were designed and synthesized as inhibitors (CDK4/6i) alleviating CIM. Among these, 42 displayed potent inhibitory activity (IC50 = 11 nM), lower cytotoxicity (CC50 > 100 μM) showed...
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases in the absence significant alcohol consumption. The aim this study was to investigate effect quercetin on insulin resistance and lipid metabolic abnormalities free acid (FFA)‑ insulin‑induced HepG2 cell model NAFLD, determine possible underlying mechanism. Quercetin markedly improves hepatic accumulation decreases levels triglyceride (TG). lipid‑lowering at concentrations between 0.1 100 µM demonstrated...
Purpose Little is known about the patterns and predictors of use end-of-life health care among patients with acute myeloid leukemia (AML). End-of-life particularly relevant for older adults AML because their poor prognosis. Methods We performed a population-based, retrospective cohort study who were ≥ 66 years age at diagnosis diagnosed during period from 1999 to 2011 died before December 31, 2012. Medicare claims used assess hospice aggressive treatment. Predictors these end points...
The objective of this study was to test the activity microbicides against herpes simplex virus type 2 (HSV-2) introduced in seminal plasma. We found that plasma interfered with PRO 2000 and cellulose sulfate, increasing by 100-fold concentration drug required inhibit 90% viral plaque formation. Seminal competitively inhibited binding HSV-2 envelope. Most interference a high molecular-weight fraction; tandem mass spectrometry identified proteins as fibronectin-1 lactoferrin. In murine model,...
The etiology of myelodysplastic syndromes (MDS) is not well understood. authors examined the relations obesity and lifestyle factors to MDS in a cohort 471,799 persons aged 50–71 years who were recruited into National Institutes Health-AARP Diet Health Study, large US prospective study, 1995–1996. Incident was diagnosed 193 during 2001–2003. A significant positive association observed between body mass index (BMI; weight (kg)/height (m)2) at baseline MDS. Compared with BMI less than 25.0,...
Little is known about the cost to Medicare of breast cancer screening or whether regional-level expenditures are associated with stage at diagnosis treatment costs, particularly because newer technologies, like digital mammography and computer-aided detection (CAD), have diffused into care older women.
Key Points Patients with IgA nephropathy and significant proteinuria are at high risk of progressive kidney function loss failure. We report the results a clinical trial assessing selective endothelin receptor antagonist SC0062 for treatment nephropathy. led to clinically meaningful improvements in did not increase peripheral edema higher doses. Background Endothelin type A activation contributes injury patients is novel antagonist. phase 2 dose-finding characterize efficacy safety Methods...
Systemic inaccuracies, proportional to the concentrations of serum proteins and thyroxine (T4) they carry, have been reported in direct free T4 immunoassays. However, analytical recoveries not carefully examined most current methods, previously across pathophysiological range binding. In present study we investigated ranges binding using total measurements from 1359 individuals. Carefully characterized, gravimetrically calibrated, serum-based test solutions were then prepared with a constant...
Background and Purpose— The study goal was to evaluate cerebral perfusion in moyamoya patients with a novel staging system investigate the association between differences of status clinical outcomes treated revascularization. Methods— About 506 consecutive from 2009 2015 were enrolled. evaluated by system-the stage preinfarction period based on result computed tomography perfusion. Hemisphere different compared hemorrhagic (n=155) ischemic (n=351). modified Rankin Scale applied prognosis...
Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (
Objective This study aims to explore the correlation between brain natriuretic peptide (BNP) levels and prognosis in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Methods retrospective included diagnosed with (aSAH) at Beijing Tiantan Hospital January 2015 September 2021. Plasma BNP were measured upon admission log-transformed reduce skewness. Elevated was defined as lgBNP ≥1.79 (equivalent ≥62 pg./mL). The primary outcome poor prognosis, a modified Rankin Scale (mRS)...
To clarify the micropore structure and fractal characteristics of Danning–Jixian block on eastern margin Ordos Basin, this study focuses deep coal rock Benxi Formation in that area. On basis an analysis quality physical properties, qualitative quantitative studies pore structures with different diameters were conducted via techniques such as field emission scanning electron microscopy (FE-SEM), low-pressure CO2 adsorption (LP-CO2A), low-temperature N2 (LT-N2A), high-pressure mercury...
To analyze the effects of intravenous propofol combined with remifentanil on whole-brain functional networks in patients ischemic moyamoya disease (IMMD) and intraspinal space-occupying lesions (SOLs) using resting-state magnetic resonance imaging (rs-fMRI). Ten IMMD 10 sex- age-matched lumbar SOL (normal cerebrovascular findings preoperative MRI) were recruited. General anesthesia was administered remifentanil. rs-fMRI performed both awake anesthetized states. Whole-brain network different...
ABSTRACT Objectives This study aimed to assess the effectiveness of biofeedback therapy on chronic constipation and sexual dysfunction in postmenopausal women. Methods multicenter, prospective, single‐blind, randomized controlled trial was conducted two hospitals China. A total 228 women diagnosed with functional self‐reported were randomly assigned either a control group, which received dietary lifestyle counseling, or an intervention same counseling plus twice weekly for 6 months. Primary...
To detect Toll-like receptor 4 (TLR4) expression and distribution in rat pancreas the change of TLR4 cerulein-induced pancreatitis (CIP).Acute was induced by subcutaneous injections cerulein at a total dose 20 microg/kg. Immunohistochemistry (IHC) used to localize pancreas, real-time reverse transcription-polymerase chain reaction (RT-PCR) quantitatively determine mRNA CIP.IHC showed presence its specifically localized pancreatic ductal epithelium, vascular endothelium, islet. No staining...
• Both of amiodarone and dronedarone can lead to pulmonary fibrosis in patients. For patients with a history exposure, switching increases the occurrence toxicity. Clinical drug precaution such substitute is requisite.