A5006683327- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Nitric Oxide and Endothelin Effects
- Oral and Maxillofacial Pathology
- Colorectal Cancer Treatments and Studies
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Cancer Diagnosis and Treatment
- Wireless Power Transfer Systems
- Bone health and treatments
Yokohama City University
2016-2025
National Cancer Center Hospital East
2011-2025
Fujita Health University
2015-2024
Fujita Health University Hospital
2024
Nagoya University of Arts and Sciences
2024
Yokohama City Seibu Hospital
2016-2023
St. Marianna University School of Medicine
2008-2023
The University of Tokyo
1978-2023
Pharmaceuticals and Medical Devices Agency
2021-2023
Niigata Cancer Center Hospital
2009-2022
Clinical evidence demonstrating the effectiveness of systemic therapy for advanced salivary duct carcinoma (SDC) is lacking because disease's rarity. We assessed efficacy and toxicity trastuzumab plus docetaxel in patients with locally and/or recurrent or metastatic human epidermal growth factor receptor 2-positive SDC.This was a single-center, single-arm, open-label, phase II study Japan. The received at loading dose 8 mg/kg, followed by 6 mg/kg every 3 weeks. Docetaxel 70 mg/m2...
BackgroundThere is no standard first-line chemotherapy for recurrent/metastatic (RM) or unresectable locally advanced (LA) salivary gland carcinoma (SGC).Patients and methodsWe conducted a single institution, open-label, arm, phase II trial of combined androgen blockade (CAB) receptor (AR)-positive SGC. Leuprorelin acetate was administered subcutaneously at dose 3.75 mg every 4 weeks. Bicalutamide orally daily 80 mg. Patients were treated until progressive disease unacceptable...
Recent studies indicate an important role for nuclear receptors in regulating lipid and carbohydrate metabolism, fibrosis, inflammation. Farnesoid X receptor (FXR) is a member of the hormone superfamily. FXR highly expressed liver, intestine, adrenal gland, kidney. The primary bile acids are highest affinity endogenous ligands FXR. effects agonists diabetic kidney disease, main cause end-stage renal however, have not been determined.To identify effect activation modulation nephropathy, we...
Multimodal therapy is a well-established approach for the treatment of sinonasal undifferentiated carcinoma (SNUC); however, optimal sequence various treatments modalities yet to be determined. This study aimed assess role induction chemotherapy (IC) in guiding definitive patients with SNUC.Ninety-five previously untreated diagnosed SNUC and treated between 2001 2018 at The University Texas MD Anderson Cancer Center were included analysis. Patients curative intent received IC before...
Currently there are no standard biomarkers of head and neck squamous cell carcinoma (HNSCC) response to therapy. This is, due a lack adequate predictive tumor models. To this end, we established cancer organoid lines from individual patient's tumors, characterized their growth characteristics different drug treatments with the objective using these models for prediction treatment response. Forty-three patients' samples were processed establish organoids. analyze character organoids,...
TP53 mutations are highly prevalent in head and neck squamous cell carcinoma (HNSCC) associated with increased resistance to conventional treatment primarily consisting of chemotherapy radiation. Restoration wild-type p53 function TP53-mutant cancer cells represents an attractive therapeutic approach has been explored recent years. In this study, the efficacy a putative reactivator called COTI-2 was evaluated HNSCC lines different status.Experimental Design: Clonogenic survival assays...
High serum level of interleukin 6 (IL-6) is associated with high degree tumor progression and systemic weakness. Anti-IL-6 therapy possibly improves the deterioration clinical characteristics in patients IL-6 level. However, IL-6-related factors treatment-naive advanced pancreatic cancer (PC) have not been established. The goal this study was to identify PC who were scheduled undergo first-line chemotherapy.Patients eligible for inclusion study. Patients did receive chemotherapy excluded....
1. Transplants of articular cartilage with a thin adjoining osseous border were inserted anatomically in the knee and wrist joints forty-two adult mongrel dogs studied histologically at intervals ranging from five to 500 days. 2. Autogenous transplants large fragments half often successful. 3. Homogenous joints, not first, but eventually, showed degenerative changes disintegration when subjected weight-bearing function. 4. Within degenerated homograft, foci persisted remained viable for more...
While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form locoregional recurrences distant metastasis, our understanding mechanisms metastasis HNSCC is limited. We initially performed upstream key nodes analysis together with whole gene microarray characterized by metastatic potential vivo lines identified JunB, a member activator protein-1 (AP-1) family, as molecule regulation pathways related to HNSCC. have therefore tested hypothesis that...
The efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted therapy androgen deprivation (ADT) for locally advanced or recurrent metastatic (LA/RM) salivary duct carcinoma (SDC) have been reported in prospective studies. However, the survival benefit these therapies to conventional remains controversial, whether HER2-targeted ADT should be chosen HER2- (AR)-positive SDC patients unknown.
Dietary potassium (K) deficiency is accompanied by phosphaturia and decreased renal brush border membrane (BBM) vesicle sodium (Na)-dependent phosphate (P i ) transport activity. Our laboratory previously showed that K in rats leads to increased abundance the proximal tubule BBM of apical Na-P cotransporter NaPi-IIa, but activity, diffusion, clustering NaPi-IIa could be modulated altered lipid composition K-deficient (Zajicek HK, Wang H, Puttaparthi K, Halaihel N, Markovich D, Shayman J,...
GBS-01, an extract from the fruit of Arctium lappa L. is orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating tolerance cancer cells glucose deprivation. We investigated maximum tolerated dose GBS-01 based on frequency dose-limiting toxicities (DLTs) and pharmacokinetics patients with advanced pancreatic refractory gemcitabine. was given at escalating doses 3.0 g (containing 1.0 burdock extract) 12.0 q.d. A DLT defined as a grade 4...
Abstract Although immune-checkpoint inhibitors (ICIs) are effective against various cancers, little is known regarding their role in salivary gland carcinoma (SGC) treatment. Therefore, we evaluated the efficacy and safety of nivolumab monotherapy patients with recurrent and/or metastatic SGC. In this multicentre retrospective study, (240 mg) was administered every 2 weeks. The overall response rate (ORR), progression-free survival (PFS), (OS), were examined; correlation between treatment...
Studies were performed in 57 patients with euthyroid Graves' disease. All of them had exophthalmos and other eye signs classes II-IV th American Thyroid Association classification. T3 suppression tests, TRHtests, measurements antithyroid antibodies all them, needle biopsy was carried out 9 patients. Twenty-seven among followed for 6 months to 3 yr. When divided into subgroups according the results tests TRH 35 (61.4%) nonsuppressive nonresponsive (group I), (10.5%) responsive II), 1 patient...
TRH tests were performed in 206 clinically and biochemically euthyroid relatives of patients with Graves' disease. In 117 the 206, T3 suppression performed. Results revealed that 56 (27.1%) showed abnormal responses to TRH. Twenty-nine these (14.1%) absent or decreased responses, 27 (13.1%) augmented Eight (6.8%) nonsuppressible. These eight subjects consisted 4 out 17 hyporesponders 90 normal responders. The majority suppressible (86 among 109) demonstrated Sixty-nine followed for 6 months...
Thrombocytopenia, microangiopathic hemolytic anemia, and elevated serum lactate dehydrogenase (LDH) clinically characterize thrombotic microangiopathy (TMA), which is frequently recognized among patients with malignant hypertension (MH). Sixteen consecutive MH were retrospectively investigated over a 7-year period clinical features of the subjects TMA evaluated. We confirmed relevant to by normalization platelet count LDH after adequate blood pressure (BP) control was achieved. Thrombotic...