A5011382201- Salivary Gland Tumors Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Ear and Head Tumors
- Pregnancy and preeclampsia studies
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroblastoma Research and Treatments
- Kawasaki Disease and Coronary Complications
- Tumors and Oncological Cases
- Coronary Artery Anomalies
- Antiplatelet Therapy and Cardiovascular Diseases
- Meningioma and schwannoma management
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Surgical Oncology
- Cancer and Skin Lesions
- Platelet Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Protease and Inhibitor Mechanisms
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Blood properties and coagulation
University of Miyazaki
2016-2025
Nippon Dental University
2022-2025
Niigata Cancer Center Hospital
2016-2025
University of Miyazaki Hospital
2015-2024
Morpho (United States)
2024
Waseda University
2024
Juntendo University
2012-2023
Niigata University
1988-2023
Registered Nurses' Association of Ontario
2023
Yasuda Women's University
2021-2023
Coupling characteristics of dual-core photonic crystal fiber (PCF) couplers are evaluated by using a vector finite element method and their application to multiplexer-demultiplexer (MUX-DEMUX) based on PCF is investigated. The for 1.48/1.55-m, 1.3/1.55-m, 0.98/1.55-m, 0.85/1.55-m wavelength MUX-DEMUX designed the beam propagation analysis proposed performed. It shown from numerical results that it possible realize significantly shorter PCFs, compared conventional optical couplers.
The aim of this study was to optimize methods for quantifying 13 uridine 5'-diphosphate-glucuronosyltransferase (UGT) isoforms (UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B10, 2B15, and 2B17) in human liver, intestinal, kidney microsomes, recombinant UGT-expressing insect cell membranes (rhUGTs) by targeted peptide-based quantification using liquid chromatography-tandem mass spectrometry. Production peptides compared combining three denaturing agents (urea, sodium deoxycholate,...
Salivary duct carcinoma (SDC) is an uncommon, aggressive malignant neoplasm histologically resembling high-grade mammary ductal carcinoma. SDC can arise de novo or ex pleomorphic adenoma. To clarify the correlation of biomarker immunoprofile with clinicopathological findings and clinical outcome SDC, we conducted immunohistochemistry for EGFR, HER2, HER3, AR, CK5/6, p53, Ki-67, along HER2 fluorescence in situ hybridization 151 SDCs. SDCs adenoma more commonly overexpressed Ki-67 than (P =...
Among salivary gland malignancies, the prognosis of duct carcinoma (SDC) is assumed to be poorest. However, because its low incidence, reliable survival estimates and prognostic factors based on a large number patients remain elucidated, thereby making it impossible standardize optimal treatment for SDC. We performed this multi-institutional, retrospective analysis by collecting clinical information 141 with SDC without distant metastasis who underwent curative surgery as initial elucidate...
<i>Background:</i> Tropomyosin and arginine kinase have been identified as crustacean allergens. During purification of from black tiger shrimp <i>Penaeus monodon,</i> we found a new allergen 20-kDa. <i>Methods:</i> A 20-kDa was purified the abdominal muscle by salting-out, anion-exchange HPLC reverse-phase HPLC. Following digestion with lysyl endopeptidase, peptide fragments were isolated HPLC, 2 them sequenced. The allergen, together tropomyosin shrimp,...
To determine the proportion of platelets and fibrin in coronary thrombi.Immunohistochemical morphometric means to examine arteries 31 patients who died acute myocardial infarction.Fresh thrombi were detected feeding infarction areas 23 cases (74%) associated with plaque rupture 18 (78%) erosion 5 (22%). An immunohistochemical study showed that consisted a mixture as well some other types blood cells. The platelet positive accounted for 74 (19)% 35 (20)% (p < 0.01) those 51 (6)% 70 (21)%,...
A novel design of polarization splitter in three-core photonic crystal fibers (PCFs) has been proposed. The PCF consists two given identical cores with two-fold symmetry separated by a core high birefringence. is based on the phenomenon resonant tunneling. Numerical simulations full vectorial beam propagation method demonstrate that it possible to obtain 1.9-mm-long extinction ratio better than -20 dB and bandwidth 37nm.
As outlined in the 2004 American Heart Association guidelines, diagnosis of Kawasaki disease (KD) is supported by results clinical laboratory studies. However, detailed information regarding evolution these during illness has not been previously reported. The goals this project were to characterize values KD before and after treatment with intravenous immunoglobulin (IVIG).Laboratory from 380 unselected, consecutive patients analyzed at 3 times: acute (illness day, 2-10; day 1 = first fever...
Very long-chain fatty acids (VLCFAs) have a variety of physiological functions and are related to numerous disorders. The key step VLCFA elongation is catalyzed by members the elongase family, ELOVLs. Mammals seven ELOVLs (ELOVL1-7), yet none them has been purified analyzed. In presented study we ELOVL7 measured its activity reconstituting it into proteoliposomes. Purified exhibited high toward acyl-CoAs with C18 carbon chain length. calculated K m values C18:3(n-3)-CoA malonyl-CoA were both...
Abstract Central nervous system high‐grade neuroepithelial tumors with BCOR alteration (CNS HGNET‐BCOR) are a recently reported rare entity, identified as small fraction of previously institutionally diagnosed so‐called CNS primitive neuroectodermal tumors. Their genetic characteristic is somatic internal tandem duplication in the 3′ end ( ITD), which has also been found clear cell sarcomas kidney (CCSK) and soft tissue undifferentiated round sarcomas/primitive myxoid mesenchymal infancy...
Minor salivary gland tumours showing a predominant papillary-cystic structure are rare, and constitute mixture of various types neoplasm; thus, the histopathological assessment these poses significant diagnostic challenge. We aimed to delineate histological characteristics further mutational aspects with particular focus on sialadenoma papilliferum (SP) intraductal papillary mucinous neoplasm (IPMN).We retrieved 28 minor glands, performed re-evaluation mutation analyses several key...
The efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted therapy androgen deprivation (ADT) for locally advanced or recurrent metastatic (LA/RM) salivary duct carcinoma (SDC) have been reported in prospective studies. However, the survival benefit these therapies to conventional remains controversial, whether HER2-targeted ADT should be chosen HER2- (AR)-positive SDC patients unknown.
Tissue factor (TF) plays a key role as primary initiator on the extrinsic coagulation cascade. Recently, upregulation of TF has been reported in human atherosclerotic lesions. We investigated effects migration and proliferation cultured smooth muscle cells (SMCs) from rabbit aortas. tested three kinds recombinant (L-TF: full length with relipidation, NL-TF: without S-TF: soluble form TF1-219). Only L-TF had coagulant activity. All showed chemotactic activity for SMCs. The ability TFs was...
Microsomal carboxylesterase activities in 12 human livers were determined using 10 kinds of substrates (p-nitrophenylacetate, p-nitrophenylpropionate, p-nitrophenylbutyrate, butanilicaine, isocarboxazid, palmitoyl-coenzyme-A, malathion, clofibrate, acetanilide, and phenacetin). There large individual differences the humans based on experimental results past several years our laboratory. We found that all liver microsomes have RH1-immunoreactive carboxylesterase, content also showed...
A 0.5% basic fuchsin-propylene glycol solution was applied to the carious dentin of extracted and vital human teeth, depths fuchsin-stained bacterial invasion were compared on histological sections. Excavation guided by this staining method always deeper than invasion, with differences between being greater in acute decay chronic decay. This is considered be a reliable clinical guide for complete removal deteriorated without causing failure remove infection completely. The images caries...
The aims of this study were to develop a robust method for simultaneous quantification carboxylesterases (CESs) 1 and 2 quantify those absolute protein levels in human liver tissue fractions. Unique peptide fragments CES1 CES2 tryptically digested microsomes (HLMs) cytosol (HLC) simultaneously quantified by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) using corresponding stable isotope-labeled peptides as internal standards. Bovine serum albumin was used blank...