A5108400667- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Colorectal Cancer Treatments and Studies
- Vascular Procedures and Complications
- Cardiac Imaging and Diagnostics
- Infectious Aortic and Vascular Conditions
- Advanced Proteomics Techniques and Applications
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Cerebrovascular and Carotid Artery Diseases
- Diagnosis and Treatment of Venous Diseases
- Diabetes Treatment and Management
- Gastric Cancer Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Neuroendocrine Tumor Research Advances
- Abdominal vascular conditions and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Kyoto University
2010-2025
Kyoto University Hospital
2020-2025
Omuta hospital
2022
Kumamoto Medical Center
2014-2020
Kindai University
2020
Kumamoto University
2009-2017
Yokohama City University
2013
Yamaguchi University Hospital
2013
Kumamoto University Hospital
2012-2013
Yokohama City University Medical Center
2013
Background: Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial dysfunction in DM patients with coronary artery disease (CAD). Methods and Results: The 40 CAD uncontrolled DM, aged 68.7±9.4 years (mean±standard deviation) (50% males, hemoglobin A1c [HbA1c] 7.4±1.0%) were assigned to either additional sitagliptin (50mg/day, n=20) or aggressive conventional (control, 6 months....
Background Endothelial dysfunction is a key component of vascular vulnerability. Reactive hyperemia index ( RHI ), as assessed by the peripheral arterial tonometry, can noninvasively evaluate endothelial function. This study was designed to determine additional prognostic value function Synergy Between PCI With Taxus and Cardiac Surgery Score SYNTAX sc) Framingham Risk FRS ) in predicting cardiovascular events high‐risk patients. Methods Results We undertook two‐center prospective 528 stable...
Several studies have reported that colchicine attenuated the infarct size and inflammation in acute myocardial infarction (MI). However, sustained benefit of administration on survival cardiac function after MI is unknown. It was hypothesized short-term treatment with could improve during recovery phase MI.Methods Results:MI induced mice by permanent ligation left anterior descending coronary artery. Mice were then orally administered 0.1 mg/kg/day or vehicle from 1 h to day 7 MI. Colchicine...
IMPORTANCE Precision oncology using comprehensive genomic profiling (CGP) by next-generation sequencing is aimed at companion diagnosis and profiling. The clinical utility of CGP before the standard care (SOC) still not resolved, more evidence needed. OBJECTIVE To investigate (FoundationOne CDx [F1CDx]) in patients with previously untreated metastatic or recurrent solid tumors. DESIGN, Setting, Participants This multicenter, prospective, observational cohort study enrolled advanced tumors...
Abstract Background The efficacy of neoadjuvant chemoradiotherapy for resectable pancreatic ductal adenocarcinoma (R-PDAC) remains unclear. This study was designed to evaluate by using intensity-modulated radiotherapy (NAC-IMRT) R-PDAC compared with upfront surgery (UpS). Methods Among 198 patients who were indicated resection between 2013 and 2021, 130 included in this after excluding underwent chemotherapy did not meet the NAC-IMRT criteria (Eligible set). planned 58 patients, UpS 72...
Expression levels of insulin-like growth factor type 1 receptor (IGF-IR), epidermal (EGFR), and HER2 expressions have been linked to clinical outcomes in several solid tumors. However, the significance these biomarkers gastric cancer (GC) remains unclear. This study was designed delineate implications three GC.The group comprised 87 patients who underwent gastrectomy at National Cancer Center Hospital subsequently received chemotherapy for recurrent or residual Using immunohistochemical...
Angina without significant stenosis, or nonobstructive coronary artery disease, attracts clinical attention. Microvascular spasm (microvascular CAS) can cause disease. We investigated the features of microvascular CAS and therapeutic efficacy calcium channel blockers.Three hundred seventy consecutive, stable patients with suspected angina presenting arteries (<50% diameter) in angiography were intracoronary acetylcholine provocation test, simultaneous measurements transcardiac lactate...
Abstract Background: The aim of this study was to identify a new plasma biomarker for use in early detection colorectal cancer. Methods: Using the combination hollow fiber membrane (HFM)-based low-molecular weight protein enrichment and two-dimensional image converted analysis liquid chromatography mass spectrometry (2DICAL), we compared proteome 22 cancer patients with those 21 healthy controls. An identified candidate then validated two larger cohorts [validation-1 (n = 210) validation-2...
The development of a new plasma biomarker for early detection would be necessary to improve the overall outcome colorectal cancer. Here we report identification and validation ninth component complement (C9) as novel cancer by cutting‐edge proteomic technologies. Plasma proteins were enzymatically digested into large array peptides, relative quantity total 94 803 peptide peaks was compared between 31 patients 59 age/sex‐matched healthy controls using 2D image‐converted analysis liquid...
Background:Endothelial dysfunction plays a crucial role in heart failure (HF), but the association between peripheral microvascular endothelial function assessed by reactive hyperemia arterial tonometry (RH-PAT) and prognosis remains unknown HF with reduced left ventricular (LV) ejection fraction (HFREF). We prospectively investigated HF-related near-future cardiovascular outcomes HFREF patients.Methods Results:The 362 patients (LVEF <50%) were followed for events (composite of death...
Abstract Background: Early detection is essential to improve the outcome of patients with pancreatic cancer. A noninvasive and cost-effective diagnostic test using plasma/serum biomarkers would facilitate cancer at early stage. Methods: Using a novel combination hollow fiber membrane–based low-molecular-weight protein enrichment LC-MS-based quantitative shotgun proteomics, we compared plasma proteome between 24 21 healthy controls (training cohort). An identified biomarker candidate was then...
<i>Objective:</i> To better understand the clinical implications of insulin-like growth factor type 1 receptor (IGF-1R), epidermal (EGFR) and HER2 expressions in gastric cancer (GC). <i>Methods:</i> The study group comprised 86 patients who received first-line chemotherapy for advanced GC at National Cancer Center Hospital. Using laser-captured microdissection a real-time RT-PCR assay, we quantitatively evaluated mRNA levels IGF-1R, EGFR paraffin-embedded specimens...
Plasma proteome analysis requires sufficient power to compare numerous samples and detect changes in protein modification, because the content of human varies significantly among individuals, many plasma proteins undergo bloodstream. A label-free proteomics platform developed our laboratory, termed "Two-Dimensional Image Converted Analysis Liquid chromatography mass spectrometry (2DICAL)," is capable these tasks. Here, we describe successful detection novel prolyl hydroxylation...
Abstract Comprehensive genomic profiling (CGP) testing by next‐generation sequencing has been introduced into clinical practice as part of precision cancer medicine to select effective targeted therapies. However, whether CGP at the time first‐line chemotherapy could be clinically useful is not clear. We conducted this single‐center, prospective, observational study investigate feasibility for chemotherapy‐naïve patients with stage III/IV gastrointestinal cancer, rare and unknown primary,...