A5075869021- Glioma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Cancer Mechanisms and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Vascular Malformations Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- Neurological diseases and metabolism
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Neuroendocrine Tumor Research Advances
- Ocular Oncology and Treatments
- Medical Imaging Techniques and Applications
- Metastasis and carcinoma case studies
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
Gunma University
2016-2025
Gunma University Hospital
2006-2025
Osaka University of Human Sciences
2022
Padjadjaran University
2019-2022
National Hospital Organization Takasaki Medical Center
2021
Gunma Prefectural Institute of Public Health and Environmental Sciences
2021
Jikei University Kashiwa hospital
2020
Jikei University School of Medicine
2020
Kumamoto University
2019
Kagawa Prefectural Central Hospital
2019
<h3>Objective:</h3> To clarify the genetic, clinicopathologic, and neuroimaging characteristics of patients with hereditary diffuse leukoencephalopathy spheroids (HDLS) colony stimulating factor 1 receptor (<i>CSF-1R</i>) mutation. <h3>Methods:</h3> We performed molecular genetic analysis <i>CSF-1R</i> in HDLS. Detailed clinical findings were retrospectively investigated. Five examined neuropathologically. <h3>Results:</h3> found 6 different mutations 7 index from unrelated Japanese...
Thymic size and density were studied in 23 untreated patients with Graves' disease 38 control subjects using computed tomography. Both thymic higher than the age-matched group. After treatment antithyroid drugs, both significantly reduced, a concomitant decrease thyrotropin receptor antibodies. PCR of human cDNA primers for amplified fragment expected receptor, its nucleotide sequence was identical to thyroid. Northern blot analysis poly(A)+ RNA demonstrated presence full length form mRNA....
<b><i>Background:</i></b> Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity. <b><i>Objective:</i></b> To assess the spectrum of and neuropathological features in 10 NIFID cases. <b><i>Methods:</i></b> Retrospective chart comprehensive review these cases was conducted. <b><i>Results:</i></b> The mean age at onset 40.8 (range 23 to 56) years, duration 4.5 2.7 13) death 45.3 28 61) years. most common presenting symptoms were...
EGFR amplification is a frequent genetic alteration in primary (de novo) glioblastomas, and often associated with structural alterations. Most common variant III (EGFRvIII), which results from non‐random 801 bp in‐frame deletion of exons 2 to 7 the gene. We assessed overexpression EGFRvIII wild‐type 30 glioblastoma biopsies. Immunohistochemically, was observed 20 (67%) glioblastomas. Eight (27%) cases also showed immunoreactivity an antibody. In 6 these cases, pattern compared serial...
Abstract Central nervous system high‐grade neuroepithelial tumors with BCOR alteration (CNS HGNET‐BCOR) are a recently reported rare entity, identified as small fraction of previously institutionally diagnosed so‐called CNS primitive neuroectodermal tumors. Their genetic characteristic is somatic internal tandem duplication in the 3′ end ( ITD), which has also been found clear cell sarcomas kidney (CCSK) and soft tissue undifferentiated round sarcomas/primitive myxoid mesenchymal infancy...
This study was conducted to investigate the feasibility and survival benefits of combined treatment with radiotherapy temozolomide (TMZ), which has been covered by national health insurance in Japanese patients glioblastoma since September 2006. Between 2006 December 2011, 47 newly diagnosed histologically confirmed received for 60 Gy 30 fractions. Among them, 45 (TMZ group) concomitant TMZ (75 mg/m2/day, every day) adjuvant (200 5 days during each 28-days). All 36 receiving between January...
Abstract Epithelioid glioblastoma (E‐GBM) is a rare aggressive variant of IDH‐wildtype newly recognized in the 2016 World Health Organization classification, composed predominantly monotonous, patternless sheets round cells with laterally positioned nuclei and plump eosinophilic cytoplasm. Approximately 50% E‐GBM harbor BRAF V600E, which much less frequently found other types glioblastomas. Most are as primary/ de novo lesions; however, several co‐ or pre‐existing lower‐grade lesions have...
To clarify the histopathological alterations of microglia in brains patients with hereditary diffuse leukoencephalopathy spheroids (HDLS) caused by mutations gene encoding colony stimulating factor-1 receptor (CSF-1R).We examined 5 autopsied and 1 biopsy specimen from a total 6 CSF-1R mutations. Detailed immunohistochemical, biochemical, ultrastructural features were examined, quantitative analyses performed.In layers 3 to 4 frontal cortex HDLS brains, showed relatively uniform delicate...
Primary CNS germ cell tumors (GCTs) are rare neoplasms predominantly observed in the pediatric and young adult populations. In line with hypothesis that primordial is cell-of-origin, histopathological examinations for this pathology involve a diverse range of components mirroring embryogenic developmental dimensions. Chemotherapy radiotherapy mainstays treatment, surgery having limited role diagnosis debulking residual tissue after treatment. While better management has been achieved over...
Oligodendrogliomas are characterized by frequent loss of heterozygosity (LOH) on chromosomes 1p and 19q, but additional genetic alterations likely to be involved. In this study, we screened 28 oligodendrogliomas (WHO grade II) 20 anaplastic III) for in the RB1/CDK4/p16INK4a/p15INK4b TP53/p14ARF/MDM2 pathways. oligodendrogliomas, hypermethylation RB1 (1 case) p14ARF (6 cases) were only detectable changes (7/28, 25%). signaling pathway regulating G1 → S transition cell cycle was altered 13/20...
Background Chemokines are involved in multiple aspects of pathogenesis and cellular trafficking tumorigenesis. In this study, we report that the latest member C-X-C-type chemokines, CXCL17 (DMC/VCC-1), recruits immature myeloid-derived cells enhances early tumor progression. Methodology/Principal Findings was preferentially expressed some aggressive types gastrointestinal, breast, lung cancer cells. expression did not impart NIH3T3 with oncogenic potential vitro, but CXCL17-expressing could...
Astroblastoma is a rare, enigmatic tumor of the central nervous system (CNS) which shares some clinicopathologic aspects with other CNS tumors, especially ependymoma. To further clarify nature astroblastoma, we performed and molecular genetic studies on eight cases astroblastoma. The median age patients was 14.5 years, ranging from 5 to 60 seven were female. All tumors arose in cerebral hemisphere radiologically appeared be well-bordered, nodular often associated cystic areas...
Recently, it was reported that ependymoblastoma and embryonal tumor with abundant neuropil true rosettes (ETANTR) show 19q13.42 amplification at a high frequency, suggesting these tumors may constitute single entity. As ependymoblastic are the most prominent features in both subtypes, multilayered (ETMR) proposed, for which represents specific molecular hallmark. However, not to ETANTR, also found few other as well immature teratomas, knowledge on is limited. In this study, we performed...
Epithelioid glioblastoma (E‐GBM) is a rare variant of (GBM), characterized by epithelioid cells with eosinophilic round cytoplasm devoid stellate cytoplasmic processes. A number studies have demonstrated that more than half E‐GBMs harbor valine to glutamic acid substitution at position 600 the serine/threonine‐protein kinase BRAF ( V600E). However, there are no previous reports on E‐GBM telomerase reverse transcriptase TERT ) promoter mutation in addition V600E mutation. Here, we report an...
Recurrent fusion genes involving C11orf95, C11orf95-RELA, have been identified only in supratentorial ependymomas among primary CNS tumors. Here, we report hitherto histopathologically unclassifiable high-grade tumors, under the tentative label of "ependymoma-like tumors with mesenchymal differentiation (ELTMDs)," harboring C11orf95-NCOA1/2 or -RELA fusion. We examined clinicopathological and molecular features five cases ELTMDs. Except for one adult case (50 years old), all were children...
Multinodular and vacuolating neuronal tumors (MVNT) have been recently referred to as a distinctive tumor entity based on histopathological findings. They are characterized by multiple nodules, vacuolar alteration widespread immunolabeling for human protein HuC/HuD. Only 13 cases reported in the literature date little is known about histopathology of these tumors. Herein, we report case MVNT with additional confirmation immunohistochemical features. A 22‐year‐old woman presented continuous...
Atypical teratoid/rhabdoid tumors (AT/RTs) are rare aggressive of the central nervous system that predominantly affect infants. Although adult AT/RT rare, accumulated cases have revealed adult-specific in sellar region. Twelve previously reported exclusively occurred females, suggesting biological differences from conventional infant AT/RT. We herein investigated a series 6 for histopathologic features, molecular status INI1/SMARCB1 gene, and clinical courses. All were ranging age 21 to 69...
Atypical teratoid/rhabdoid tumors (AT/RT) are rare, aggressive, embryonal brain that occur most frequently in very young children; they characterized by rhabdoid cells and loss of INI1 protein nuclear expression. Here, we report the case a 24-year-old man with left frontal lobe tumor was composed mainly showing reactivity polyphenotypic immunohistochemical expression, small INI1-positive component ependymoma. Array comparative genomic hybridization separately conducted for each...
Abstract Epithelioid glioblastoma is among the rarest variants of and not formally recognized in W orld H ealth O rganization classification; it composed monotonous, discohesive sheets small, round cells with eccentric nuclei eosinophilic cytoplasm devoid cytoplasmic stellate processes, showing retention nuclear staining INI ‐1 protein. Here, we report a case involving 22‐year‐old man right occipital lobe tumor, which comprised mainly epithelioid tumor small area diffusely infiltrating less...
Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type diabetes mellitus by blocking the reabsorption kidneys. Dapagliflozin metabolized and inactivated UGT1A9. Empagliflozin UGT1A9 other related isoforms UGT2B7, UGT1A3, UGT1A8. Tofogliflozin five different enzymes CYP2C18, CYP3A4, CYP3A5, CYP4A11, CYP4F3. treatment HCT116 cells, which express SGLT2 but not...
The current study aimed to evaluate the outcomes of patients with adenocarcinoma (AC) uterine cervix after definitive radiotherapy (RT) and prognostic factors, including immunity-related molecules. A total 71 AC from multiple Japanese institutions were retrospectively analysed. Histological subtypes diagnosed according 2014 World Health Organization classification. All underwent RT comprising external beam intracavitary brachytherapy or without concurrent chemotherapy. Immunohistochemical...