A5101954162- Glioma Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- CNS Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- Thermoregulation and physiological responses
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Carcinogens and Genotoxicity Assessment
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Inhalation and Respiratory Drug Delivery
- Nanoplatforms for cancer theranostics
- Myasthenia Gravis and Thymoma
- MicroRNA in disease regulation
- Biochemical effects in animals
- Radiomics and Machine Learning in Medical Imaging
- Tuberous Sclerosis Complex Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Diaphragmatic Hernia Studies
Fujita Health University
2018-2025
Fujita Health University Hospital
2019-2025
Nagoya City University
1974-2024
Hokuriku Electric Power Company (Japan)
2019
Mayo Clinic in Arizona
2016-2018
Mayo Clinic
2016-2017
Gunma University
2016-2017
WinnMed
2016-2017
Hidaka Hospital
2016
The University of Tokyo
2016
Pleomorphic xanthoastrocytoma (PXA) is a rare localized glioma characterized by frequent BRAF V600E mutation and CDKN2A/B deletion. We explored the association of copy-number variants (CNVs) with mutations, tumor grade, patient survival in cohort 41 PXA patients using OncoScan chromosomal microarray. Primary resection specimens were available 38 cases, including 24 14 anaplastic (A-PXA), 23 mutant tumors (61%). CNVs identified all cases most frequently involved chromosome 9 homozygous...
The power loss of Mn-Zn ferrites and its dependency on the microstructural factors have been investigated. was found to be lowered due formation a high-electrical-resistive boundary layers, which is accomplished by an addition specific refractory oxides, are concentrated grain form layer with CaO. new material, having low at high frequency (∼1 MHz), has developed HfO2 addition.
Atypical teratoid/rhabdoid tumors (AT/RT) are rare, aggressive, embryonal brain that occur most frequently in very young children; they characterized by rhabdoid cells and loss of INI1 protein nuclear expression. Here, we report the case a 24-year-old man with left frontal lobe tumor was composed mainly showing reactivity polyphenotypic immunohistochemical expression, small INI1-positive component ependymoma. Array comparative genomic hybridization separately conducted for each...
Karnofsky Performance Status (KPS) is a widely used scale to assess performance status. KPS ≥ 50% implies that patients can live at home. Therefore, maintaining important improve the quality of life with glioblastoma, whose median survival less than 2 years. This study aimed identify factors associated time maintenance (survival 50%) in IDH-wildtype. Ninety-eight glioblastomas, IDH-wildtype, who were treated concomitant radiotherapy (RT) and temozolomide (TMZ) followed by TMZ therapy, start...
ABSTRACT Colorectal cancer (CRC) is well characterized in terms of genetic mutations and the mechanisms by which they contribute to carcinogenesis. Mutations APC , TP53 KRAS are common CRC, indicating key roles for these genes tumor development progression. However, certain tumors with low frequencies that defined location molecular phenotypes, a carcinogenic mechanism dependent on BRAF has been proposed. We here analyzed targeted sequence data linked clinical information focusing high...
Molecular irreversibleness with Helicobacter pylori (H. pylori) infection might have a role in gastric tumorigenesis after H. eradication. We performed comprehensive DNA methylation profiling of mucosa eradication or without cancer. Using four different groups biopsies obtained from body history (Hp-), cancer (cancer-free body), early diagnosed (EGC body) and their paired samples adjacent ADJ), status five candidate genes (MYOD1, SLC16A12, IGF2, RORA PRDM5) was examined by the bisulfite...
Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies conventional cerebrospinal fluid (CSF) analyses. To determine whether detection of genetic mutations enables differentiation these diseases the early CNSL, we performed mutational analysis CSF liquid biopsy technique.In this study, extracted cell-free DNA from (CSF-cfDNA) CNSL (N = 10), disease 10)...
Mucosa‐associated lymphoid tissue (MALT) lymphoma arising in the thymus is a rare disorder that shows strong association with autoimmune disease. Several MALT‐lymphoma‐specific and ‐associated chromosomal abnormalities, including t(11;18), t(14;18), t(1;14), trisomy 3 18, are known to occur. The former translocation results apoptosis inhibitor 2 gene ( API2 )–MALT lymphoma‐associated 1 MALT1 ) fusion. In this study, we examined 14 cases of thymic MALT lymphomas for API2–MALT1 fusion using...
Secondary fungal infections are a critical problem that accompany immunosuppressive therapy for severe coronavirus disease 2019 (COVID-19). We report fatal case of COVID-19 with disseminated mucormycosis diagnosed during autopsy. A 58-year-old man diabetes was hospitalized and treated remdesivir, systemic steroids tocilizumab. Following treatment, he provided extracorporeal membrane oxygenation support. However, died multiple organ failure accompanied by pulmonary kidney infarction, as...
The transvascular fluid shift after blood volume modification was analyzed by means of continuous determination and stimulation analysis. On splenectomized dogs, 15% the circulating withdrawn retransfused, while volume, hematocrit colloid osmotic pressure were continuously monitored. Based on results, stimulated a two-compartment model. compliance intravascular interstitial spaces as well filtration coefficient determined whole body, simultaneously. No statistically significant differences...
Meningiomas are a common pathology in the central nervous system requiring complete surgical resection. However, cases of recurrence and post-irradiation, accurate identification tumor remnants dural tail under bright light remains challenging. We aimed to perform real-time intraoperative visualization meningioma using delayed-window indocyanine green (ICG) technique with microscopy. Fifteen patients intracranial received 0.5 mg/kg ICG few hours before observation during surgery. used...
Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change a network, have been reported as unique form cell death. In this study, immunohistochemical analysis METs human glioblastoma was performed. To distinguish between macrophages, multiple immunostainings with Iba1 combined CD163 or CD204 were present small...
The case of a patient with gastric adenosquamous carcinoma positive cancer cells on intraperitoneal washing cytology (CY1) who achieved long recurrence-free survival is herein reported. A 74-year-old man was found to have the stomach. Partial gastrectomy performed, and pathological examination confirmed diagnosis invasion into serosa lymph node metastasis. S-1 monotherapy administered because cytologic revealed that patient's peritoneal washings were for cells. remains alive no recurrence...
Although rare, thymic mucosa-associated lymphoid tissue (MALT) lymphoma is considered to be a distinct clinicopathological entity. Using methylation-specific polymerase chain reaction, we analyzed MALT lymphomas (n = 18) for their methylation of the following seven tumor suppressor genes: DAPK1, p16(INK4A), p14(ARF), CDH1, RARB, TIMP3 and MGMT. Reactive lymph nodes 16) were used as control. Of genes examined, had an increased number that methylated (2.9 genes) compared with reactive (0.63, p...
Pleomorphic xanthoastrocytoma (PXA) has rarely been reported in combination with infiltrating glioma, historically interpreted as a "collision tumor." Isocitrate dehydrogenase 1 (IDH1) and BRAF V600E mutations are usually not concurrent. The former is typical of adult gliomas, the latter identified variety primary central nervous system neoplasms, including PXA, ganglioglioma, pilocytic astrocytoma, gliomas. We report case 56-year-old man presenting seizures headaches. Magnetic resonance...