Kohei Fukuoka
A5074061983- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Reconstructive Surgery and Microvascular Techniques
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Fetal and Pediatric Neurological Disorders
- Cardiac and Coronary Surgery Techniques
- Electron and X-Ray Spectroscopy Techniques
- Platelet Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
Saitama Children's Medical Center
2019-2024
Yamato Municipal Hospital
2024
Kyushu University
2022-2024
Tottori University Hospital
2016-2023
Creative Commons
2023
Center For Reconstructive Urethral Surgery
2023
Committee on Publication Ethics
2023
National Cancer Research Institute
1997-2022
Saitama Medical University
2011-2022
Palmetto Hematology Oncology
2022
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors a higher mortality rate, while high-grade better outcome. However, we little understanding of their biology therefore cannot explain this nor what constitutes optimal management. Here report comprehensive genetic analysis an international cohort clinically annotated infant gliomas, revealing 3 subgroups. Group 1 arise the cerebral hemispheres harbor alterations receptor tyrosine...
We integrated clinical, histopathological, and molecular data of central nervous system germ cell tumors to provide insights into their management.Data from the Intracranial Germ Cell Tumor Genome Analysis (iGCT) Consortium were reviewed. A total 190 cases classified as primary (GCTs) based on pathological reviews.All but one that bifocal (neurohypophysis pineal glands) with multiple lesions including neurohypophysis or gland germinomas (34 35). Age was significantly higher in patients...
Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas distinct profiles are likely to be different diseases. The presence C11orf95-RELA fusion genes in a subset (ST-EPN) indicated the existence subgroups. However, pathogenesis RELA fusion-negative remains elusive. To investigate these validate classification tumors, we conducted thorough 113 locally diagnosed from 107 patients Japan Pediatric Molecular Neuro-Oncology Group. All...
Abstract Glioblastoma is one of the most devastating human malignancies for which a novel efficient treatment urgently required. This pre–clinical study shows that eribulin, specific inhibitor telomerase reverse transcriptase ( TERT )‐RNA‐dependent RNA polymerase, an effective anticancer agent against glioblastoma. Eribulin inhibited growth 4 promoter mutation‐harboring glioblastoma cell lines in vitro at subnanomolar concentrations. In addition, it suppressed cells transplanted...
Primary CNS germ cell tumors (GCTs) are rare neoplasms predominantly observed in the pediatric and young adult populations. In line with hypothesis that primordial is cell-of-origin, histopathological examinations for this pathology involve a diverse range of components mirroring embryogenic developmental dimensions. Chemotherapy radiotherapy mainstays treatment, surgery having limited role diagnosis debulking residual tissue after treatment. While better management has been achieved over...
Abstract The diagnosis of ependymoma has moved from a purely histopathological review with limited prognostic value to an integrated diagnosis, relying heavily on molecular information. However, as the approach is still novel and some subtypes are quite rare, few studies have correlated pathology clinical outcome, often focusing small series single types. We collected data 2023 ependymomas classified by DNA methylation profiling, consisting 1736 previously published 287 unpublished profiles....
Abstract Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor group. The natural history, when curative resection not possible, one of a chronic disease with periods stability and episodes progression. While there high overall survival rate, many patients experience significant potentially lifelong morbidities. majority pLGGs have an underlying activation RAS/MAPK pathway due to mutational events, leading use molecularly targeted therapies in clinical trials, recent...
Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, paucity of relapses precluded additional analyses markers relapse. To address this gap in knowledge, an international cohort 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763–0.925) with 15 relapsed individuals identified. Maintenance chemotherapy strong predictor relapse,...
Abstract Background Both genetic and methylation analysis have been shown to provide insight into the diagnosis prognosis of many brain tumors. However, implication profiling its interaction with alterations in pediatric low-grade gliomas (PLGGs) are unclear. Methods We performed a comprehensive PLGG long-term clinical follow-up. In total 152 PLGGs were analyzed from range pathological subtypes, including 40 gangliogliomas. Complete molecular was compared genome-wide data outcome all...
Recurrent fusion genes involving C11orf95, C11orf95-RELA, have been identified only in supratentorial ependymomas among primary CNS tumors. Here, we report hitherto histopathologically unclassifiable high-grade tumors, under the tentative label of "ependymoma-like tumors with mesenchymal differentiation (ELTMDs)," harboring C11orf95-NCOA1/2 or -RELA fusion. We examined clinicopathological and molecular features five cases ELTMDs. Except for one adult case (50 years old), all were children...
CNS germ cell tumors (GCTs) predominantly develop in pediatric and young adult patients with variable responses to surgery, radiation, chemotherapy. This study aimed examine the complex largely unknown pathogenesis of GCTs.We used a combined transcriptomic methylomic approach 84 cases conducted an integrative analysis normal cells undergoing embryogenesis testicular GCTs.Genome-wide transcriptome GCTs indicated that germinoma had profile representative primitive during early high...
Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested impact was varied by stage. This study analyzed prognostic sidedness in stages II, III, and liver metastasis resection using propensity-matched analysis.Right-sided defined as a located from cecum splenic flexure, while any more distal left-sided cancer. Patients who underwent at Nara Medical University hospital between 2000 2016 were analyzed.There 110...
Abstract Complete loss of nuclear SMARCB1 expression was originally described as a hallmark malignant rhabdoid tumors, typically occurring in the kidney, soft tissue, and central nervous system (CNS). Generally, deficiency is associated with histopathological appearance, except for some rare tumors. Herein, we present case hitherto undescribed SMARCB1‐deficient pulmonary mesenchymal tumor without features or histopathology involving 62‐year‐old male patient. Histologically, demonstrated...
OBJECTIVE Human chorionic gonadotropin (HCG) can be detected in a certain population of patients with germinoma, but the frequency germinoma HCG secretion and prognostic value CSF are unknown. METHODS The authors measured levels sera histologically confirmed by using highly sensitive assay known as an immune complex transfer enzyme immunoassay (EIA), which is more than 100 times conventional method, they analyzed correlation between prognoses germinoma. RESULTS 35 were examined EIA. median...
Aims Alterations in microenvironments are a hallmark of cancer, and these alterations germinomas particular significance. Germinoma, the most common subtype central nervous system germ cell tumours, often exhibits massive immune infiltration intermingled with tumour cells. The role cells germinoma, however, remains unknown. Methods We investigated cellular constituents their clinical impacts on prognosis 100 germinoma cases. Results Patients lower content (i.e. higher infiltration) had...
Abstract Background A methylation-based classification of ependymoma has recently found broad application. However, the diagnostic advantage and implications for treatment decisions remain unclear. Here, we retrospectively evaluate impact surgery radiotherapy on outcome after molecular reclassification adult intracranial ependymomas. Methods Tumors diagnosed as ependymomas from 170 patients collected 8 institutions were subjected to DNA methylation profiling. Molecular classes, patient...